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We introduce DiffPhy, a differentiable physics-based model for articulated 3d human motion reconstruction from video. Applications of physics-based reasoning in human motion analysis have so far been limited, both by the complexity of constructing adequate physical models of articulated human motion, and by the formidable challenges of performing stable and efficient inference with physics in the
Confidential computing allows processing sensitive workloads in securely isolated spaces. Following earlier adop- tion of process-based approaches to isolation, vendors are now enabling hardware and firmware support for virtualization-based confidential computing on several server platforms. Due to variations in the technology stack, threat model, implemen-tation and functionality, the available s
Finding correspondences between shapes is a fundamental problem in computer vision and graphics, which is relevant for many applications, including 3D reconstruction, object tracking, and style transfer. The vast majority of correspondence methods aim to find a solution between pairs of shapes, even if multiple instances of the same class are available. While isometries are often studied in shape
Representing 3D shape deformations by high-dimensional linear models has many applications in computer vision and medical imaging. Commonly, using Principal Components Analysis a low-dimensional subspace of the high-dimensional shape space is determined. However, the resulting factors (the most dominant eigenvectors of the covariance matrix) have global support, i.e. changing the coefficient of a
Achaete-scute family bHLH transcription factor 1 (ASCL1) is a master transcription factor involved in neuroendocrine differentiation. ASCL1 is expressed in approximately 10% of lung adenocarcinomas (LUAD) and exerts tumor-promoting effects. Here, we explored miRNA profiles in ASCL1-positive LUADs and identified several miRNAs closely associated with ASCL1 expression, including miR-375, miR-95–3p/m
Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti-seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and long-lasting solutions. By addressing the underlying c
Second language acquisition (SLA) research has historically prioritized classroom-based contexts, with the exception of areas such as study abroad, incidental and self-directed learning. In the last decades, however, research interest in second language (L2) learning beyond the classroom has grown substantially, expanding our understanding of where and how L2 learning takes place. This can be larg
The ability to store and mobilize energy is fundamental for physiologic function. Most excess energy is stored in adipose tissue as triglycerides, which is released as free fatty acids when needed through cellular processes tightly regulated by insulin. Intact adipose cell function is essential to regulate whole-body glucose and lipid metabolism. Several studies have focused on the metabolic impac
Background: There is evidence to suggest that frontline community health workers in Malawi are under-referring children to higher-level facilities. Integrating a digitized version of paper-based methods of Community Case Management (CCM) could strengthen delivery, increasing urgent referral rates and preventing unnecessary re-consultations and hospital admissions. This trial aims to evaluate the a
Following the recent discovery of the first radial velocity planet in a star still possessing a protoplanetary disc (CI Tau), we examine the origin of the planet's eccentricity (e ~0.3). We show through long time-scale (10^5 orbits) simulations that the planetary eccentricity can be pumped by the disc, even when its local surface density is well below the threshold previously derived from short ti
We investigate the adaption of the recently developed exponential integrators called EPIRK in the so-called domain-based implicit-explicit (IMEX) setting of spatially discretized PDE's. The EPIRK schemes were shown to be efficient for sufficiently stiff problems and offer high precision and good stability properties like A- and L-stability in theory. In practice, however, we can show that these st
Background: Screening for islet autoantibodies in children and adolescents identifies individuals who will later develop type 1 diabetes, allowing patient and family education to prevent diabetic ketoacidosis at onset and to enable consideration of preventive therapies. We aimed to assess whether islet autoantibody screening is effective for predicting type 1 diabetes in adolescents aged 10−18 yea
The heating effects of three PCM vests (Tmelt=32, 28 and 24 °C) were tested on a thermal manikin with constant temperature at 30 ºC in a subzero environment (Ta=-4 °C, Va=0.4 m/s). The results showed that the heating effects lasted about 3-4 hours. The highest heating effects reduced heat loss for 20-30 W/m2 on the torso during the first two hours. The results also showed that the vest with higher
Summary Approximately 10% of the patients diagnosed with type 2 diabetes (T2D) have detectable serum levels of glutamic acid decarboxylase 65 autoantibodies (GADA). These patients usually progress to insulin dependency within a few years, and are classified as being latent autoimmune diabetes in adults (LADA). A decrease in the frequency of peripheral blood natural killer (NK) cells has been repor
Following systemic injection, hematoporphyrin derivative (HPD) is known to be selectively retained in malignant tissue. This property can be used in a two-fold way: a) for localizing tumours by observing the characteristic dual-peaked laser-induced fluorescence from HPD, and b) for photodynamic therapy (HPD-PDT) using a localized HPD-assisted singlet oxygen release induced by irradiation of 630 nm
