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Most products are developed while adapting to requirements from industrial production and logistics. To break that trend and design for people, we suggest focusing on those who put the strongest demands on the final solution. They cannot compensate for bad design solutions and are thereby, like sniffing dogs, guiding designers to meet peoples’ needs. We always use a combination of empathic modelli
The effects of inhaled 1,1,1-trichloroethane (3500, 6000, and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose consumption were studied in awake rats. The effect of the solvent inhalation on the EEG pattern and local cerebral blood flow was also studied in paralyzed animals under N2O analgesia. Exposure of awake animals to 6000 ppm 1,1,1-trichloroethane induced a decrea
Huge dynamic Stark shifts of atomic energy levels in xenon induced by high-intensity laser light have been measured by a new method based upon multiphoton ionization by a tunable femtosecond laser source. Stark-induced multiphoton resonances appear as identifiable structures in the photoelectron energy spectra. The change in the structures positions, when the photon energy is tuned, is directly re
Families often prefer home care to hospital care, and home-care services for ill children are increasing worldwide with limited knowledge of families’ needs during curative and palliative home care. The aim of this study was to elucidate family members’ lived experience when a sick child received home care from county-based primary healthcare services. A descriptive qualitative design was chosen a
After an initial clarification of the notion of the risk, a brief discussion of the distinction between testing and screening, and of the difficulties of defining genetic information in a precise way follows an overview of public concerns raised by genetic testing and screening. Next section reviews various types of ethical issues in this context. The challenges are not the same for all types and
This paper deals with noise suppression in multichannel measurements, using a certain signal model but without assuming stationarity of the signals involved. This enables application to signals whose spectral characteristics are time-variable. The novelty consists of an algorithm for obtaining an approximation of the Wiener filter for each channel. The filters are computed using the Weyl transform
Typhoon Haiyan hit the Philippines on 8th November 2013 destroying more than 1 million houses and affecting mostly the poor. This paper discusses user involvement in housing recovery from a capability perspective. The paper also analyses possibilities for extension of the housing solutions. Based on the Sphere handbook and the theoretical framework, a Model for user involvement in evolutionary hou
We introduce and apply a new approach to probe the response of galactic stellar haloes to the interplay between cosmological merger histories and galaxy formation physics. We perform dark matter-only, zoomed simulations of two Milky Way-mass hosts and make targeted, controlled changes to their cosmological histories using the genetic modification technique. Populating each history's stellar halo w
European Spallation Source ERIC (ESS ERIC) is a legal entity established by the European Commission based on a European Union regulation (the ERIC Regulation). It is co-hosted by Sweden and Denmark and has its statutory seat in Lund, Sweden. This means that, according to the ERIC Regulation, ESS ERIC is a legal subject of both EU law and Swedish national law. In terms of hierarchical interplay bet
The study investigates the center of gravity in onset fricatives as a main acoustic feature to assess the relation between vowel pronunciation and coarticulatory spectral characteristics of the onset consonant. /s/- and /f/-initial CV sequences were analyzed with backness, roundedness and height of the vowel as predictors of fricative center of gravity. Results showed that the first 15 ms of an on
Cytoreduction followed by hyperthermic intraperitoneal chemotherapy is a treatment option for peritoneal surface malignancies in The Netherlands. This treatment has been available for more than 10 years. Therefore, long-term results on survival and quality of life can now be studied. With these results, the true long-term benefits of this new management strategy can be determined.
Despite laws, policies and visions to create cities and societies for all, barriers still exclude persons with disabilities from using buildings and public places. Our study aimed to identify choices made during the urban development process that include or exclude users in the built environment; how and when these choices arise during the process; and what is needed to implement universal design
Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is more complex than MT approaches. Expressing ihMT in terms of MT-saturation (ihMTsat) is a first step to quantification as it corrects for underlying T and B . Larger ihMTsat was observed for smaller frequency offsets, which is explained using MTsat as proxy for bound pool s
For the longest of times, commerce and empire have been held to reside in perfect isolation from one another. Conceptually, peaceful commerce starkly opposed the discord of empires. In that same vein, political economy – the tool of commerce – was often considered the natural counterpart of warfare – the tool of empire. In many regards political economy was – and still is – considered an appealing
