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Design of recombinant antibody microarrays for global proteome analysis

Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recom

Prosodic signaling of information and discourse structure from a typological perspective

This study investigates the relationship between prosody and information/discourse structure in spon- taneous spoken folk tales in the tonal Mon-Khmer language Northern Kammu, a language that behaves as a typical phrase language where available boun- dary tones are enhanced to mark information struc- turing. Topic is always placed before Comment by syntactic movement if necessary. There is a proso

Legal and Social Norms for Development:Why legal reform of the informal economy failed to influence vulnerable groups in developing countries

Using the concepts of social norms and social reality, this chapter explores why legal reforms that aimed to facilitate the formalization of informal workers have largely failed to influence vulnerable groups in developing countries. It explores the use of legal reforms in order to achieve development and poverty reduction. Using empirical material from a qualitative study conducted in Colombia am

Covariance Analysis, Positivity and the Yakubovich-Kalman-Popov Lemma

This paper presents theory and algorithms for covariance analysis and stochastic realization without any minimality condition imposed. Also without any minimality conditions, we show that several properties of covariance factorization and positive realness hold. The results are significant for validation in system identification of state-space models from finite input-output sequences. Using the R

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity.

Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic acids has recently been implicated in the development of cancer and other pathological conditions; however, the mechanism of EV uptake and how this may be targeted remain as important questions. Here, we provide evidence that heparan sulfate (HS) proteoglycans (PGs; HSPGs) function as internalizing recepto

DNA-Surfactant interactions, compaction, condensation, decompaction and phase separation

Recent investigations-of the interaction between DNA and alkyltrimethyl ammonium bromides of various chain lengths are reviewed. Several techniques have been used such as phase map determinations, fluorescence microscopy, and electron microscopy. Dissociation of the DNA-surfactant complexes, by the addition of anionic surfactant, has received special attention. Precipitation maps for DNA-cationic

Sonographic Investigation of the Rectoanal Inhibitory Reflex: A Qualitative Pilot Study in Healthy Females.

PURPOSE: The rectoanal inhibitory reflex has been studied using various methods, e. g., anometry and electromyography. The aim of this study was to apply ultrasound for direct visualization of the rectoanal inhibitory reflex. METHOD: The rectoanal inhibitory reflex was induced in ten healthy females (age range, 21 - 55 years) by injection of small amounts of water (7, 12, and 20 ml), into the rect

Red giant stellar collisions in the Galactic Centre

We show that collisions with stellar-mass black holes can partially explain the absence of bright giant stars in the Galactic Centre, first noted by Genzel et al. We show that the missing objects are low-mass giants and asymptotic giant branch stars in the range 1-3 M-circle dot. Using detailed stellar evolution calculations, we find that to prevent these objects from evolving to become visible in

Helicobacter pylori infection in children in Estonia: Decreasing seroprevalence during the 11-year period of profound socioeconomic changes

Background. The prevalence of Helicobacter pylori infection is inversely associated with socioeconomic conditions in childhood. In Estonia, a high prevalence of H. pylori infection has been observed among children born in 1987 and earlier. Since 1991, after the dissolution of the USSR, profound social and economic changes have taken place in the country. The aim of the study was to evaluate change

Earth System governmentality Reflections on science in the Anthropocene

This paper examines Earth System Science as a novel approach to global environmental change research. Drawing upon Michel Foucault's governmentality concept, the paper opens up the Earth System metaphor to political analysis and asks what it does to our understanding of nature and society as a governable domain. We trace the scientific practices that have produced the Earth System as a thinkable a

The relationship between ADHD and anxiety in boys: Results from a family study

OBJECTIVE: Recent studies have found an increased risk for both anxiety disorder and attention-deficit hyperactivity disorder (ADHD) in the adult relatives of children with ADHD in comparison with adult relatives of normal controls. Such findings may account for the high rates of comorbid anxiety found in children with ADHD, and they suggest a relationship between the two disorders. However, addit

Helicobacter pylori antibodies and gastric cancer: a gender-related difference

Helicobacter pylori has been proposed as a causative agent of gastric cancer. The aim of this study was to define serum antibodies response against different H. pylori antigens in patients with gastric cancer. Serum samples were collected from 115 Lithuanian patients with non-cardia gastric cancer and 110 age- and sex-matched controls without cancer. Heat-stable, low-molecular-mass, and outer memb