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Basophils are emerging as immunoregulatory cells capable of interacting with their environment not only via their characteristic IgE-mediated activation, but also in an IgE-independent manner. Basophils are known to express and respond to stimulation via TLR2, TLR4, DC-SIGN and DCIR, but whether basophils also express other C-type lectin receptors (CLRs) is largely unknown. In this study, we inves

Wireless capsule endoscopy (WCE) is the prime diagnostic modality for the small-bowel. It consists in a swallowable color camera that enables the visual detection and assessment of abnormalities, without patient discomfort. The localization of the capsule is currently performed in the 3D abdominal space using radiofrequency (RF) triangulation. However, this approach does not provide sufficient inf

Background and purpose — Backside wear of the polyethylene insert in total knee arthroplasty (TKA) can produce clinically significant levels of polyethylene debris, which can lead to loosening of the tibial component. Loosening due to polyethylene debris could theoretically be reduced in tibial components of monoblock polyethylene design, as there is no backside wear. We investigated the effect of

This article sketches a transdisciplinary theoretical framework for understanding the so-called Anthropocene in terms of global inequalities. The concept of the Anthropocene has several profound implications that challenge central aspects of the modern worldview. Its relation to issues of global justice requires a cataclysmic reconceptualization of conventional notions of development, economic gro

The Georgian Orthodox Church (GOC) organisation has 15 departments, which focus on a wide range of areas from missionary work to finance, economy, real estate, ecology and military. This chapter focuses on historical and political contexts that shaped the GOC as an organisation over time. The GOC’s organisation is headed by Patriarch Ilia, while the administrative–operational part is conducted by

The intestinal surface is daily challenged with tremendous amount of foreign material derived our diet and from the commensal bacteria that densely populate the mucosal surface. Occasionally the gut mucosa is exposed to pathogens trying to enter our body. The important task of the intestinal immune system is to remain tolerant toward innocuous luminal constituents and to elicit defense responses t

Supermassive black holes are found in most galactic nuclei. A large fraction of these nuclei also contain a nuclear stellar cluster surrounding the black hole. Here we consider the idea that the nuclear stellar cluster formed first and that the supermassive black hole grew later. In particular we consider the merger of three stellar clusters to form a nuclear stellar cluster, where some of these c

As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity,

The present contribution addresses a crystal plasticity formulation which incorporates hardening effects that are related to the presence of geometrically necessary dislocations. To this end, higher gradient contributions are introduced as additional arguments of the energy function based on microstructural considerations. Extending the derivations presented in Kaiser and Menzel (2019) for a purel

Resistivity measurements in marine environments have already been tested in Norwegian landscapes in in the detection of subsea fracture zones (Lile et al. 1994; Dalsegg, 2012). Yet, most of the produced data have been processed without taking into account the special conditions created by the presence of seawater. Similar studies outside of Norway (Tsourlos et al., 2001; Satriani et al., 2011; Ruc

Initiatives to upscale repair activities are becoming increasingly common, with the latestbeing the EU commission’s proposal to strengthen consumers’ right to repair. However, theseinitiatives are not viewed comprehensively, particularly not for how they impact the product user’sexperience of the repair process, and what type of repair conditions would emerge once fullyimplemented. This gap exists