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All living cells require specific mechanisms that target proteins to the cell surface. In eukaryotes, the first part of this process involves recognition in the endoplasmic reticulum of amino-terminal signal sequences and translocation through Sec translocons, whereas subsequent targeting to different surface locations is promoted by internal sorting signals(1). In bacteria, N-terminal signal sequ
Two protected derivatives of beta-D-galactopyranosyl-5-hydroxy-L-lysine, in which HO-4 of galactose has been O-methylated or replaced by fluorine, have been prepared. The building blocks were incorporated at position 264 of the peptide fragment CII259-273 from type II collagen by solid-phase synthesis. The ability of these two glycopeptides, and two CII259-273 glycopeptides in which HO-4 of galact
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without
Haptoglobin phenotypes have been shown in human medicine to be related to the prevalence of various diseases. Furthermore, abnormal glycosylation of haptoglobin has been reported as a consequence of liver disease, cancer and immunological disorders in man. To our knowledge, similar findings have not, so far, been reported in canine disease. The present paper describes a method for investigation of
The paper presents a computer-based decision support system for watershed planning and flood design purposes including a conceptual rainfall-runoff model. The software package uses up-to-date programing techniques in Windows environment which makes it flexible to handle, adaptable to new areas, and easy to test for different design criteria. The package is suitable for design problems in small as
BACKGROUND. Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the modulation of growth and progression of prostate cancer. Decreased expression of the tyrosine phosphatase SHP-1, involved in regulation of cytokine and tyrosine kinase receptor signaling, has been shown to be associated with less favorable outcome among prostate cancer patients. METHODS. Parental LNCaP c
Lysozyme adsorption to charged surfaces was studied by Monte Carlo simulations at different protein concentrations, protein net charges, ionic strengths, and surface charge densities. The lysozyme was represented by a hard sphere with embedded positive and negative surface charges parametrically dependent on the solution pH. A short-range attractive protein-protein potential was included to repres
Control of emission by intermolecular fluorescence resonant energy transfer (IFRET) and intermolecular charge transfer (ICT) is investigated with the quantum-chemistry method using two-dimensional (2D) and three-dimensional (3D) real space analysis methods. The work is based on the experiment of tunable emission from doped 1,3,5-triphenyl-2-pyrazoline (TPP) organic nanoparticles (Peng, A. D.; et a
Objective: In lymphedema management, lower limb volume is commonly assessed by circumference measurementevery 4th cm which is however time-consuming. The aim of this study is to evaluate the agreement between volumemeasurements derived from circumference measurements every 4th cm (V4) with every 8th cm (V8) and every 12th cm(V12) in patients with lower limb lymphedema (LLL) and to determine the te
As has been argued by systems thinking scholars, science and scientific thinking can be seen as socially constructed systems of institutionalized sets of activities through which systems thinking emerged. In this paper, the development of systems approaches is discussed to argue for the research approach adopted. Further, main concepts of systems thinking such as complexity, worldview, and human a
In this chapter, we analyze Finnish and Swedish economic history research on these countries’ common past (prior to 1809) and the early modern era (defined here as between 1500 and 1850). Using extensive bibliometric databases, we show that even when they focus on the early modern era, economic historians most often analyze Finland and Sweden in terms of their modern borders. Researchers based in
This thesis investigates whether the stock market in the Baltic countries exhibit herd behavior during the period 2006-2014. A quantitative approach is used to see if investors show group oriented mentality in Estonia, Latvia, and Lithuania, and in the Baltics as whole. This is further complemented with a qualitative approach. The quantitative part is based on a market wide approach. The models pr
Vad är problemet? (What is the problem?) is about human right defenders protecting the land, territorial and environment and the situation about the ongoing criminalization in Guatemala. The purpose of this essay is to highlight and understand how the State of Guatemala is talking about the represented problem (criminalization) by studying the discourse about the implementation from presented poli
This research seeks to investigate access to justice in Liberia, specifically delving into corruption in the Liberian Judiciary and its nexus to pretrial detention
The global pandemic of Covid-19 has drastically changed the behaviour of citizens around the world. This research aims to identify actions that ensure low-carbon, inclusive forms of mobility that respond to the behavioural changes during Covid-19. The city of Hamburg, Germany, and its problems with transport-related emissions and socio-economic inequalities serve as a representative case study. Th
The student group is an emerging target with high potential for both the service industry and municipalities. However, previous studies scrutinizing this segment have been limited despite its significance. The aim of this study is to provide a deeper understanding of how domestic and international students perceive Helsingborg city and to offer insight into the key factors influencing students’ pe
This thesis seeks to develop an understanding of racial stereotyping in the Netherlands, through examining the role of public authorities in the societal debate on the character of Zwarte Piet. It is the portraying of this character that can contribute to negative racial stereotyping. How did the societal debate come to its current form, and what role do public authorities have, or what role shoul
