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Lipid A (a hexaacylated 1,4' bisphosphate) is a potent immune stimulant for TLR4/MD-2. Upon lipid A ligation, the TLR4/MD-2 complex dimerizes and initiates signal transduction. Historically, studies also suggested the existence of TLR4/MD-2-independent LPS signaling. In this article, we define the role of TLR4 and MD-2 in LPS signaling by using genome-wide expression profiling in TLR4- and MD-2-de

We present rock magnetic and palaeointensity data from Holocene Icelandic lava flows, including historical and pre-historical lavas. Susceptibility versus temperature measurements indicate that the magnetic mineralogy is dominated by primary titanomagnetite that have experienced variable degrees of high-temperature oxidisation. The analyses also demonstrate that virtually all studied samples are t

The size of the anisotropic domains in a lyotropic liquid crystal is estimated using a new protocol for diffusion NMR. Echo attenuation decays are recorded for different durations of the displacement-encoding gradient pulses, while keeping the effective diffusion time and the range of the wave vectors constant. Deviations between the sets of data appear if there are non-Gaussian diffusion processe

Bet-hedging is defined as a strategy that reduces the temporal variance in fitness at the expense of a lowered arithmetic mean fitness. After a few technical points, we will here argue that this definition of bet-hedging is badly suited for models with density- and/or frequency-dependent fitness. A strict interpretation cannot be employed; possibly, a modified definition is necessary.

Recombination in the well-performing bulk heterojunction solar cell blend between the conjugated polymer TQ-1 and the substituted fullerene PCBM has been investigated with pump-probe transient absorption and charge extraction of photo-generated carriers (photo-CELIV). Both methods are shown to generate identical and overlapping data under appropriate experimental conditions. The dominant type of r

We report the signature of an unconventional zwitterion in thick (>40 angstrom) L-cysteine films grown at low temperature (100 K) by means of sublimation in ultrahigh vacuum. Using X-ray photoelectron spectroscopy (XPS) we find that protonated amino groups (57%) are less prevalent than in films grown at higher temperatures. A large majority of the protonated amino groups receive the hydrogen throu

This study explores the influences of steric hindrance and excited state solvent ligation on the excited state dynamics of Cu(I) diimine complexes. Ultrafast excited state dynamics of Cu(I)bis(3,8-di(ethynyltrityl)-1,10-phenanthroline) [Cu(I)(detp)(2)](+) are measured using femtosecond transient absorption spectroscopy. The steady state electronic absorption spectra and measured lifetimes are comp

This thesis investigates the translations of seven contemporary western works of literature into Chinese. The translations are analysed using the translation analysis method used by David van der Peet in his analysis of the translation of The Lord of The Rings into Chinese applying concepts and criteria formulated by the translation theorists Walter Benjamin, Eugene Nida and Paolo Bartolini. This

This thesis attempts to answer the question why there was a breakdown in talks between India and the USA over the issue Special Safeguard Mechanism (SSM), at the WTO Ministerial Conference in Geneva in July 2008. This is done through Robert Putnams’ two-level game framework, which is applied to the interplay between India’s diplomacy and domestic politics. The thesis concludes that the underd

Utifrån en fri tolkning av Porters generiska strategier har vi genom tre delresultat svarat på om kunden uppfattar COS som stuck in the middle. Mycket tyder på att dagens konsument blir allt mer kvalitetsmedveten och långsiktig i sina köpvanor. Vi ser COS som ett exempel på hur lågprisföretagen väljer att möta denna konsumtionstrend och hur satsningen väljer att kommuniceras. Genom att word-of-mou

2005 avgiftsbelades periodieringsfonden, tidigare hade den varit en skattefri kredit från staten. I och med avgiftsbeläggningen var företagen tvugna att ta ställning till om den var värd att betala för. Lagstiftarna hävdade att det var de stora bolagen som skulle drabbas hårdast av förändrigen medan kritikerna hävade motsatsen. I denna kvantitativa undersökning har genom intervjuer med tio företag