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Polyploidization is an important driver of evolution and diversification in flowering plants. Here, we assess how repeated polyploidization may have shaped diversification of floral morphology in Lithophragma bolanderi (Saxifragaceae). This species comprises multiple cytotypes and varies geographically in its interactions with specialized pollinating moths in the genus Greya (Prodoxidae). Past stu

Popular Abstract in Swedish Att bär är nyttigt är ett påstående som de flesta känner igen. På butikshyllorna trängs våra nordiska bär med exotiska ”superbär” som utlovar att göra oss friska. Men vilka hälsoeffekter kan egentligen uppnås genom att äta bär? Är vissa bär mer nyttiga än andra? Forskningsresultaten som presenteras i denna avhandling visar att lingon, svarta vinbär och blåbär kan motverThe increasing prevalence of obesity is a worldwide health problem closely linked to diet and lifestyle factors. Obesity is associated with increased risk of several metabolic disorders including insulin resistance, nonalcoholic fatty liver disease and type 2 diabetes. Hence, there is a great need to identify dietary strategies for the prevention of obesity and related diseases. This thesis invest

Adsorption of trimethyl phosphate (TMP) on well-characterized hematite, maghemite and goethite nanopartides was studied by in situ DRIFT spectroscopy as a model system for adsorption of organophosphorous (OP) compounds on iron minerals. The iron minerals were characterized by X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS)

Pregnancy-induced immune modulation might lead to reactivation of latent tuberculosis infection (LTBI). This thesis explores aspects of immune-based LTBI diagnostics and how pregnancy affects the immune control of Mycobacterium tuberculosis (Mtb) infection. We studied a prospective cohort of women recruited during pregnancy in Ethiopia. LTBI testing was performed by quantification of interferon-γ

Nearly US$25 trillion is currently invested through Collective Investment Vehicles (hereinafter: “CIVs”) worldwide. CIVs calculate net asset values (hereinafter: “NAV”) on a daily basis, since such values are the basis for subscriptions and redemptions. In calculating net asset values, a CIV must take into consideration any withholding tax benefits by applicable tax treaties. CIVs require certaint

This BA-thesis examines whether realism can be empirically tested on the Iraq war in 2003. I am inspired by Mearsheimer's offensive realism, which holds that all states are aggressive because of the structure of international politics. Realism has a lot of theories about power, which I examine extensively and then apply empirically. Realism states that there are two strategies for a states? su

Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN

This chapter provides an overview of the different optical sectioning methods that enable performing three dimensional (3D) imaging of possibly complex samples. It discusses their benefits and limitations regarding their penetration depth, their imaging speed, their photo-toxic effect or their complexity. Focusing on fluorescence imaging, the chapter dives into approaches that make it possible to

Growth and immune development—fundamental parts of any organism's ontogeny—depend critically on nutrient availability, particularly on essential amino acids that support protein synthesis and physiological processes. However, environmental variation can reduce prey diversity and nutrient quality, producing suboptimal diets that lack essential amino acids, potentially constraining development. In t

Genetic analyses are now routinely used as an adjunct to traditional morphologic and immunohistochemical investigations in the diagnosis of many neoplasms, including soft tissue tumors. Many genetic features are strongly associated with morphologic features, and a rapidly growing subset of mutations promise to shed light on patient outcome. This chapter discusses major molecular pathogenetic featu

De svenska specialistpsykiatrin arbetar just nu för att gå från ett traditionellt biomedicinskt synsätt till ett mer återhämtningsinriktat perspektiv. Återhämtningsinriktade insatser handlar om att ge stöd som hjälper personer att hitta mening i sina liv och i sina sammanhang, oavsett vilka svårigheter de har. Det innebär ett helhetsperspektiv där målet är personlig återhämtning genom egenmakt ochThe Swedish specialist mental health services are striving to shift from abiomedical to a recovery-oriented perspective. Recovery-oriented servicesprovide care and support that help persons in finding meaning in their livesand within their communities, regardless of their mental health needs. Itentails a holistic approach towards persons with mental health needs, strivingfor personal recovery thro

Democratic argument is not failing for lack of logic. It is failing because the shared ground beneath logic – the premises citizens once held in common – has fractured under information environments engineered for engagement rather than truth. When the same evidence is anchored by incompatible starting points, argument cannot cross; communities harden into fortresses built not from facts, but from

Activation of the kynurenine pathway (KP) with resulting accumulation of neuroactive metabolites may be a downstream pathophysiological mechanism of inflammatory depression. The aims of this study were to investigate KP metabolites in inflammatory depression compared to non-inflammatory depression and healthy controls, and whether these metabolites change with nutraceutical interventions with pote

In the Netherlands, the role of the woman in society has changed drastically in the past century. Furthermore, over the past 50 years, marriage between man and woman lost its dominant position to alternative forms of cohabitation. These developments in society and civil law are also reflect-ed in the Dutch Personal Income Tax Act (PITA) and the Dutch Gift and Inheritance Tax Act (GITA) and will be

In 2005, Pachon et al.1 proposed cardiac vagal denervation to treat neurally mediated syncope. Since then, a metanalysis of observational studies2 and a recent randomized controlled trial (RCT)3 have provided some evidence that cardioneuroablation (CNA) is able to prevent syncope recurrence at least during the first 2 years following the procedure in patients affected by reflex syncope. In brief,

Maternal vaccination, resulting in transfer of protective IgG across the placenta, represents a promising strategy to prevent neonatal disease caused by group B Streptococcus (GBS). The prototype vaccine GBS-NN, a fusion protein consisting of the N-terminal domains of the alpha-like protein (Alp) family members AlphaC and Rib, has been shown to display a good safety profile and to elicit a strong