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Levi on the Reality of Dispositions

Isaac Levi is more interested in inquiry and how it progresses than he is in metaphysics. Questions concerning the role of disposition predicates in inquiry are more central to him than those concerning the nature and reality of dispositions. It has not stopped him from giving me and others very useful metaphysical advice. Currently, where empirical metaphysics is in vogue, there is every reason t

C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend.

C4b-binding protein (C4BP) is best known as a potent soluble inhibitor of the classical and lectin pathways of the complement system. This large 500kDa multimeric plasma glycoprotein is expressed mainly in the liver but also in lung and pancreas. It consists of several identical 75kDa α-chains and often also one 40kDa β-chain, both of which are mainly composed of complement control protein (CCP) d

Load and lock: the molecular mechanisms of B-lymphocyte commitment.

Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for mo

Research techniques for the study of code-switching

The aim of this chapter is to provide researchers with a tool kit of semi-experimental and experimental techniques for studying code-switching. It presents an overview of the current off-line and on-line research techniques, ranging from analyses of published bilingual texts of spontaneous conversations, to tightly controlled experiments. A multi-task approach used for studying code-switched sente

The "Mental" in Monumental : Battle Axe Culture in megalithic tombs in southern Sweden

It is reasonable to consider that those who arranged the material accoutrements of mortuary practices, i.e. the burial, were making a more or less conscious statement about cultural identity. At least we archaeologists usually assume this to be so. An interesting case can be found in the mortuary practices ascribed to the Battle Axe culture from the later Middle Neolithic1 (2800–2350 cal BC) in so

Knowledge of evolution and evolution of knowledge

It is argued that evolution goes beyond that which can be described in a well-defined language) and that it instead enforces a language that is itself evolving. Evolution is the unfolding of this self-reference. The unfolding methodology of the logician Alfred Tarski is taken as a basis for the explicability of evolution. Looking at Tarski´s results as a linguistic complementarity, we get a view w

Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: Comparison with peptidoglycan

Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal levels of potency in isolated mononuclear cells and whole blood, suggesting that peptidoglycan is an important inducer of procoagulant activity in severe sepsis involving gram-positive bacteria.

Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4+ CDw29- CD45R- p80- human T lymphocytes.

Functionally distinct subsets within the T-helper (CD4+) cell population have been described in man, rat and mouse. We have shown previously that the CD4+ 45R- human lymphocytes are producers of IL-2 within 24 hr of polyclonal stimulation and are the major interferon (IFN) producers. The mAbs 4B4 (CDw29) and Leu 8 (p80) are here used together with Leu-18 (CD45R) to characterize the subpopulations