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Global Chronic Total Occlusion Crossing Algorithm: JACC State-of-the-Art Review

The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel qu

From Edith Carlmar to Iram Haq: Women in the Norwegian Film Industry

Norway is one of the best countries in the world when it comes to gender equality, ranking in second place only behind Iceland in the 2018 Global Gender Gap Report. The film industry, however, is and has always been dominated by men, and change in this field has been quite slow—at least until the last decade. Operating in a small country, with 5.3 million inhabitants in 2019, the industry is depen

Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells

We present a unifying theory to explain cancer recurrence, therapeutic resistance, and lethality. The basis of this theory is the formation of simultaneously polyploid and aneuploid cancer cells, polyaneuploid cancer cells (PACCs), that avoid the toxic effects of systemic therapy by entering a state of cell cycle arrest. The theory is independent of which of the classically associated oncogenic mu

Colonial Extractivism and Development: The state and private diamond extraction at the British Cape Colony, 1870-1910

In this paper we investigate the specific mechanisms of British financial influence in the Cape Colony during the diamond mining boom of the late nineteenth century. We do so by offering a detailed exposition of the uneasy marriage between the colonial state and private business sector in the context of the economics and dynamics of extractivism in the periphery. This allows us to encapsulate the

‘Lease the land, but use the water’ : The case of gambella, Ethiopia

Gambella is one of the regional states in Ethiopia where huge tracts of land have been leased out to domestic and international investors since the global food, fuel and financial crisis of 2007/2008. The Gambella region is also one of the most marginalized regions in Ethiopia. It has been alienated from the central politics and socio-economic activities of the state. In the past, the Gambella reg

Habits and perceived boundary control in everyday working life -telework in the era of COVID-19among Swedish municipality workers

Every day we perform several recurring activities with little or no guidance from conscious intention. These daily and repetitive actions are often referred to as habits. The situation with Covid-19 has had a dramatic impact on how we go about our daily lives and how we interact with other persons at home or at work. In relation to working life one specific aspect was that many office workers were

Gender and willingness to lead: Does the gender composition of teams matter?

We explore how team gender composition affects willingness to lead by randomly assigning participants in an experiment to male- or female-majority teams. Irrespective of team gender composition, men are substantially more willing than women to lead their team. The pooled sample, and women separately, are more willing to lead female- than male-majority teams. An analysis of mechanisms reveals that

Nursing Studentsʼ Recounts of Actions and Interactions in Social Relations in Danish Homecare Settings: Perspectives of Immigrant Nursing Students

Encounters between patients in homecare and nursing students are cultural events where students, in principle, are in unknown territory. This study illuminated how nursing students recount (inter)actions in social relations in Danish homecare settings, illustrated by students with a self-appointed immigrant background. The study consisted of semi-structured interviews with eight nursing students.

Impact on quality of life of an intervention providing additional information to patients with allergic contact dermatitis; a randomized clinical trial

Background: Allergic contact dermatitis can negatively impact an individual's daily life in terms of work and interpersonal relationships. Patch-tested individuals show an improved quality of life (QoL). Objectives: We aimed to assess the impact on QoL after patch testing and what value an intervention would have on QoL. Methods: Dermatology Quality of Life Index (DLQI) were assessed in participan

A link between Krüppel-like factor 4, complement activation, and kidney damage

Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that

Science, Language, and Reform in Victorian Poetry : Political Dialects

Barrow’s timely book is the first to examine the link between Victorian poetry, the study of language, and political reform. Focusing on a range of literary, scientific, and political texts, Barrow demonstrates that nineteenth-century debates about language played a key role in shaping emergent ideas about popular sovereignty. While Victorian scientists studied the origins of speech, the history o

Degradation of human secretory immunoglobulin A by Blastocystis

Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B.