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Protein HC-IgA complexes carry antibody activities

Polyclonal protein HC-IgA complexes (HC-IgA) were isolated from two different serum pools. Their hydrodynamic volumes were found to be slightly greater than that of monomeric IgA but less than that of dimeric IgA. Sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis of reduced and carboxymethylated complexes followed by immunoblotting showed that the complexes contained normal light an

On the relative stabilities of H- And D-bonded water dimers

The infrared spectra of water dimers formed from H2O, D 2O, and HDO in krypton matrices have been recorded. Thermal equilibria between H- and D-bonded dimers have been studied. D bonding is preferred, and H-bonded dimers are approximately 60 cm-1 less stable than D-bonded dimers. The energy difference seems to be due to the higher value of the intermolecular out-of-plane H-bond shear vibration com

Towards understanding critical flows - a literature review

Critical infrastructure such as transportation, power, telecommunication and water supply systems accommodate and enable flows of essential goods and services that modem societies are highly dependent upon. These critical flows connect countries, organizations and communities, and are imperative for upholding vital societal functions. Disruptions of such flows hold the potential of severe and pote

Science audited: Indicator-based systems for research evaluation and resource allocation

This paper presents an ongoing research project investigating the use of bibliometrics for research evaluation and resource allocation purposes, and to investigate the effects of these evaluation models on individual, organizational and political levels. A main focus has been on bibliometrics based evaluation practices. The use of bibliometrics for local resource allocation at Swedish universities

A Theory of Gazelle Growth: Competition, Venture Capital Finance, and Policy

This paper proposes a theory of gazelle growth in which gazelles can grow either organically or through acquisitions. The model includes three types of firms: incumbent, target, and gazelle. We show that the lower cost of organic growth can increase the incentives for acquisition growth because the incumbent understands that if it acquires the target firm, the gazelle will then invest organically

Wavelet networks for face processing

Wavelet networks (WNs) were introduced in 1992 as a combination of artificial neural radial basis function (RBF) networks and wavelet decomposition. Since then, however, WNs have received only a little attention. We believe that the potential of WNs has been generally underestimated. WNs have the advantage that the wavelet coefficients are directly related to the image data through the wavelet tra

High-sensitivity troponin T is an important independent predictor in addition to the Simplified Acute Physiology Score for short-term ICU mortality, particularly in patients with sepsis

Purpose: Elevated cardiac troponin levels have been shown to be associated with a poor prognosis under some intensive care conditions. This study investigated whether inclusion of high-sensitivity troponin T (hsTnT) increased the prognostic accuracy of the Simplified Acute Physiology Score (SAPS 3) for general intensive care unit (ICU) patients, cardiac arrest patients, or patients with a non-card

Dynamics and Coherent Control of Exciton-Exciton Annihilation in Aqueous J-Aggregate

In aqueous solution of 1,1'-diethyl-2,2'-carbocyanine J-aggregate, the exciton self-trapped (EST) state is usually expected to be negligible. However, in this work, by measuring transient absorption spectroscopy under a variety of excitation fluences, the EST state was found to be formed via coherent exciton-exciton annihilation (EEA), when the excitation fluence was high enough. With the existenc

Acidosis enhances translocation of protein kinase C but not Ca2+/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia

Systemic hyperglycemia and hypercapnia severely aggravate ischemic brain damage when instituted prior to cerebral ischemia. An aberrant cell signaling following ischemia has been proposed to be involved in ischemic cell death, affecting protein kinase C (PKC) and the calcium calmodulin kinase II (CaMKII). Using a cardiac arrest model of global brain ischemia of 10 min duration, we investigated the

Models for studying long‐term recovery following forebrain ischemia in the rat. 2. A 2‐vessel occlusion model

ABSTRACT— A model is described in which transient ischemia is induced in rats anaesthetized with N2O:O2 (70:30) by bilateral carotid artery clamping combined with a lowering of mean arterial blood pressure to 50 mm Hg, the latter being achieved by bleeding, or by bleeding supplemented with administration of trimetaphan or phentolamine. By the use of intubation, muscle paralysis with suxamethonium

Cortical spreading depression is associated with arachidonic acid accumulation and preservation of energy charge

The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin