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Purpose – The purpose of this paper is to explore the brand core and its management over time. The aim is to develop a framework for managing the core of a brand for continuity and change. Design/methodology/approach – A longitudinal case study of the Volvo brand’s core and its management serves as the empirical basis for a qualitative analysis of the “brand core” using rhetorical perspectives. Fi
Structural properties, independent of specific parameter values, can explain the robustness of biochemical systems. In this paper we consider the framework previously proposed by the authors to assess structural stability of biochemical reaction networks with monotone reaction rates, which considers systems in concentration coordinates, and we show that the results can be applied to systems in rea
The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed
A recurrent problem in ecology and conservation biology is to estimate the risk of population extinctions. Extinction probabilities are not only imperative for conservation and management, but may also elucidate basic mechanisms of the regulation of natural populations. The usual way of modelling stochastic influence on population dynamics has been to assume that the external noise is uncorrelated
Background: The choice between different attention-deficit/hyperactivity disorder (ADHD) medications depends on different drug attributes. Economic evaluations of drugs often disregard the utility of other attributes compare with the drugs' efficacy. Aims: The aim of this study was to assess patient's preferences and elicit willingness-to-pay (WTP) for different drug attributes in the treatment of
Chronic neural interfaces that are able to record or stimulate neurons in the CNS are valuable instruments in use today and they hold great promise for the future both within neuroscience research and in the clinic. However, a major obstacle is that they show a decline in performance over time. Many different approaches to improve the interface designs are gradually evaluated in hope of overcoming
We analyze the classical problem of the interaction between two charged surfaces separated by a solution containing neutralizing counter-ions. The focus is on obtaining a description where the solvent is treated explicitly rather than through a dielectric approximation as is conventionally done. We summarize the results of three papers where we have used a Stockmayer fluid model in Monte Carlo sim
The Apollonian tiling of the plane into circles is analyzed with respect to its group properties. The relevant group, which is noncompact and discrete, is found to be identical to the symmetry group of a particular geometric tree graph in hyperbolic three-space. A linear recursive method to compute the radii is obtained. Certain modifications of the problem are investigated, and relations to other
Background and aims: Radiotherapy is a valid treatment in cancer multimodal management but it is affected by severe systemic and local side effects. A murine small bowel model was used for the investigation of inflammatory features and apoptosis of local radiotherapy. Similarly the same model was used to analyze the combined effects of radiotherapy and antibiotics in the expression of matrilysin,
The last years have been characterized by tremendous institutional change in the university sector induced by far-reaching Higher Education Reforms (e.g. Bologna). Building on loose-coupling theory, we hypothesize that smaller universities were better able to adapt to the Higher Education Reforms of the recent years, triggering a decline in the optimal size of universities in the reform period. Us
What explains the gender gap in ideology, i.e. the observation that women tend to be more leftist than men? We provide new evidence showing that personality traits play a key role. Using a novel high-quality data set, we show that the mediating (i.e. indirect) effects of gender operating through personality traits by far dominate the direct effects of gender. They also dominate other potential dif
The Sustainable Development Goals (SDGs) have placed great emphasis on the need for much greater social inclusion, and on making deliberate efforts to reach marginalized groups. People with disabilities are often marginalized through their lack of access to a range of services and opportunities. Assistive products can help people overcome impairments and barriers enabling them to be active, partic
Background: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxaemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxaemia who do not meet the criteria for LTOT
