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Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-ge
A new aromatic pair, 2-hydroxy-6-methoxybenzamide/1-methylpyrrole at the terminal position of hairpin polyamides has been designed for distinguishing T·A from A·T base pairs and both from G·C/C·G in the minor groove of DNA. Four eight-ring hairpin polyamides with benzamide (Bz), 2-hydroxybenzamide (Hb-1), 2-hydroxy-6-methylbenzamide (Hb-2), and 2-hydroxy-6-methoxybenzamide (Hb-3) at the N-terminal
To better predict the timely variation of algal blooms and other vital factors for safer drinking water production, a new AI scanning–focusing process was investigated for improving the simulation and prediction of algae counts. With a feedforward neural network (FNN) as a base, nerve cell numbers in the hidden layer and the permutation and combination of factors, etc., were fully scanned to selec
To investigate the influence of gas injection timing (GIT) on the combustion instability of a premixed natural gas engine, experiments were conducted under low load conditions using various GITs. Multifractal and multiscale entropy analyses were employed to examine the fractal characteristics and complexity of the experimental time series for indicated mean effective pressure (IMEP) and heat relea
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to impro
The suitability of Hansen solubility parameters as descriptors for modelling analyte retention during reversed-phase chromatographic experiments was investigated. A novel theoretical model using Hansen solubility parameters as the basis for a complete mathematical derivation of the model was developed. The theoretical model also includes the cavitation volumes of the analytes, which were calculate
Despite the recent experimental and theoretical progress in the investigation of the nuclear fission process, a complete description still represents a challenge in nuclear physics because it is a very complex dynamical process, whose description involves the coupling between intrinsic and collective degrees of freedom, as well as different quantum-mechanical phenomena. To improve on the existing
It is shown that the commonly used approximation for the no-loss angle-resolved photocurrent from solids in general violates the optical selection rules if the final-state inverse low-energy electron diffraction orbital is taken to be damped. The violations occur in the velocity formula, which is inconsistent with the corresponding and commonly used acceleration formula in which the matrix element
In 1995, Best et al. published a formula for the exact bit error probability for Viterbi decoding of the rate R=1/2, memory m=1 (2-state) convolutional encoder with generator matrix G(D)=(1 1+D) when used to communicate over the binary symmetric channel. Their method was later extended to the rate R=1/2, memory m=2 (4-state) generator matrix G(D)=(1+D^2 1+D+D^2) by Lentmaier et al. In this paper
This article aims at introducing to a wider circle a complementary research approach in user oriented work. Its most fundamental part is the use of technology as a tool for capturing the needs, wishes and dreams of a user. The incitement for us to start developing this method was an experience based, serious, questioning of conventional methods such as interviews, questionnaires, etc, and their c
