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Therapy is the often-used treatment for cancer patients, even those that undergo resection surgery. While milestones have been surpassed throughout the decades for a number of cancer types, there are those that comprise of characteristics limiting effectiveness of treatments. For these, such as some breast and pancreatic cancers, other pursuits must be explored to identify avenues for beneficial t

The Parkinson's disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the diary for quantification of motor states in comparison to direct clinical observation. 51 patients (median age: 65 years, disease duration: 11 years) completed th

This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are aut

Legal pluralism provided a useful alternative framework because pluralism had always sought to identify hybrid legal spaces, where multiple normative systems occupied the same social field. An emphasis on legal pluralism also freed scholars from endless intractable debates about whether international law is truly law given that coercive enforcement power in the international and transnational aren

The fusion-evaporation reaction 32S + 28Si at 125 MeV beam energy was used to populate high-spin states in the semimagic N = 28 nuclei 53Mn and 54Fe. With a combination of the Gammasphere spectrometer and ancillary devices including the Microball CsI(Tl) array, extensive high-spin level schemes are derived. They exhibit rotational-like collective structures and competing single-particle excitation

Over the last three years, the idea of a ‘post-truth society’ has become a common talking point. Politicians from around the world, from Europe to South America to the United States, have been labelled as ‘post-truth leaders’, with Donald Trump being portrayed as the standard bearer for this new kind of political discourse. This article suggests that post-truth leadership is nothing new. Ever sinc

Rather than exogenous endowments, natural resources can be seen as economically exploitable resources thanks to knowledge improvements. This underscores the need to understand why some natural resource abundant countries are able to develop their own technologies while others are not. We tackle this issue by looking at the evolution of engineering faculties and graduate engineers from 1850 to 1939

The abrupt emergence of COVID-19, has ushered in health crises around the world and has affected global security. This pandemic shows that the relationship between security affairs and global health is becoming one of the more complicated topics in world politics. The states’ unilateral and individualized response to this transnational threat marks a shift in international relations away from glob

OBJECTIVE: To investigate if prolonged TTS after completed nCRT improves postoperative outcomes for esophageal and esophagogastric junction cancer. SUMMARY OF BACKGROUND DATA: TTS has traditionally been 4-6 weeks after completed nCRT. However, the optimal timing is not known. METHODS: A multicenter clinical trial was performed with randomized allocation of TTS of 4-6 or 10-12 weeks. The primary en

Background: The integration of first- and second-generation bioethanol processes has the potential to accelerate the establishment of second-generation bioethanol on the market. Cofermenting pretreated wheat straw with a glucose-rich process stream, such as wheat grain hydrolysate, in a simultaneous saccharification and fermentation process could address the technical issues faced during the biolo

Global environmental change is rapidly altering the dynamics of terrestrial vegetation, with consequences for the functioning of the Earth system and provision of ecosystem services. Yet how global vegetation is responding to the changing environment is not well established. Here we use three long-term satellite leaf area index (LAI) records and ten global ecosystem models to investigate four key

Background: Digital breast tomosynthesis (DBT) is considered superior to digital mammography (DM) for women with dense breasts. Purpose: To identify differences in screening outcomes, including rates of recall, false-positive (FP) findings, biopsy, cancer detection rate, positive predictive value of recalls and biopsies, and histopathologic tumor characteristics by density using DBT combined with