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PURPOSE: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC.EXPERIMENTAL DESIGN: The efficacy of HDACi
We use a novel method to define the R&D team and use the unexpected death of an R&D worker to study its effect on the organization of R&D teams in profit-making firms. Average treatment effects on exit probability, entry probability, wages of stayers, and characteristics of leavers are null. Hires are slightly younger in treatment than control. Treatment effects do not vary by the size
A search for long-lived particles decaying into hadrons is presented. The analysis uses 139 fb−1 of pp collision data collected at s = 13 TeV by the ATLAS detector at the LHC using events that contain multiple energetic jets and a displaced vertex. The search employs dedicated reconstruction techniques that significantly increase the sensitivity to long-lived particles decaying in the ATLAS inner
EU competition policy report
Playing outdoors in nature with peers has been attributed most importance for children's healthy development but is increasingly marginalized because of the attractiveness of screen-based play. Careful merging of digital technology into outdoor play environments rich on nature elements could potentially help bridge digital play with more traditional play activities outdoors. A systematic compariso
I provide a unified account of hope and fear as propositional attitudes. This “mirror account” is based on the historical idea that the only difference between hope and fear is the conative attitude involved, positive for hope and negative for fear. My analysis builds on a qualified version of the standard account of hope. The epistemic condition is formulated in terms of live possibility and the
The Biomass Action Plan (BAP) for Europe outlines how to achieve the targets for bioenergy and energy crops defined by the European Commission and member states. However, it is the Common Agricultural Policy (CAP) that shapes the utilisation of agricultural land. This paper therefore reviews the supportive measures for energy crops in recent CAP reforms and investigates the effects on farmers in ‘
The fundamental limits of the gain and efficiency of an antenna are explored. The antenna is confined in a sphere and all of the currents are assumed to run in a material with a conductivity that is a function of the radial coordinate. The analysis is based on the expansion of the electromagnetic fields in terms of vector spherical harmonics. Explicit expressions for the limits of gain and efficie
Anorthoscopic vision: Designing and Sensing the Future Tom O’Dell As a means of thinking about the future and issues of uncertainty, I would like to take my point of departure in a project I completed a few years ago (O’Dell 2013) concerning plans to develop a huge particle sciences facility in Lund, called the European Spallation Source (ESS). I was the only ethnologist working with a team of 1
Popular Abstract in Swedish Prostanoider, en samlingsbeteckning för prostaglandiner och tromboxaner, tillverkas av de flesta av kroppens olika celltyper och fungerar som en slags hormoner i många olika organsystem i människor och djur. Prostanoiderna bildas alla från prostaglandin H2 som i sin tur tillverkas av enzymet cyklooxygenas (COX) från fettsyran arachidonsyra. Prostanoiderna är alltså fettProstanoids are ubiquitously distributed lipid signaling molecules derived from arachidonic acid, that exhibit numerous and diverse biological effects in a variety of physiological and pathophysiological conditions. The cell surface receptors for the prostanoids belong to the family of G protein-coupled receptors. In this thesis, the author describes the cloning and structural characterization of
