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Background: Particle exposure is a risk factor for cardiovascular diseases. Mitochondrial DNA (mtDNA) is a primary target for oxidative stress generated by particle exposure. We aimed to elucidate the effects of occupational exposure to particle-containing welding fumes on different biomarkers of mtDNA function, and in turn, explore if they modify the association between particle exposure and card
Power electronics result in increased harmonic distortion, but can also be used for harmonic mitigation. This requires simple, low order models for nonlinear networks. The Harmonic Norton Equivalent is a load model structure that supports aggregation of nonlinear loads, and makes nonlinear network solving (i.e. simulation) a non-iterative procedure. It is a linearized description of the relation b
Recently, mass spectrometry (MS) has emerged as an important tool for high-throughput screening (HTS) providing a direct and label-free detection method, complementing traditional fluorescent and colorimetric methodologies. Among the various MS techniques used for HTS, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) provides many of the characteristics required for high-th
Increasing use of the ground as a thermal reservoir is expected in the near future. Shallow geothermal energy (SGE) systems have proved to be sustainable alternative solutions for buildings and infrastructure conditioning in many areas across the globe in the past decades. Recently novel solutions, including energy geostructures, where SGE systems are coupled with foundation heat exchangers, have
Wetlands are one of the most significant natural sources of methane (CH4) to the atmosphere. They emit CH4 because decomposition of soil organic matter in waterlogged anoxic conditions produces CH4, in addition to carbon dioxide (CO2). Production of CH4 and how much of it escapes to the atmosphere depend on a multitude of environmental drivers. Models simulating the processes leading to CH4 emissi
ObjectivesThe main objective of this study was to derive cost estimates of five major foodborne illnesses (campylobacteriosis, salmonellosis, enterohemorrhagic Escherichia coli (EHEC), yersiniosis and shigellosis) in Sweden. These estimates provide a necessary contribution to perform future cost-benefit analyses aimed at reducing the burden of foodborne disease. A secondary aim was to obtain estim
An analytical method is presented, combining novel microcontact imprinting technique and capacitive biosensor technology for the detection of BSA. Glass cover slips were used for preparation of protein stamps. The microcontact-BSA imprinted gold electrodes were prepared in the presence of methacrylic acid (MAA) and poly-ethylene glycol dimethacrylate (PEGDMA) as the cross-linker by bringing the pr
I vår kropp finns en myriad av proteiner och celler med viktiga funktioner och de flesta av dem är täckta av kolhydrater. Galektiner är en familj proteiner som har en ficka där olika kolhydrater kan binda in. Genom att kolhydrater på celler eller andra proteiner binder in till denna ficka kan galektiner påverka cellulära funktioner. Vid cancer och inflammation har överproduktion av vissa galektineGalectins are a class of β-galactoside-binding proteins that bind glycoconjugates and have been implicated in cancer, regulation of immunity and inflammation. Design and synthesis have achieved highly potent and selective galectin ligands that can inhibit interactions with glycoproteins and have consequent cellular effects. These ligands can be used as tools to further elucidate the roles of galec
Witnessing violence toward a caregiver during childhood is associated with negative impact on children's health and development, and there is a need for effective interventions for children exposed to intimate partner violence in clinical as well as in community settings. The current effectiveness study investigated symptom reduction after participation in two established group interventions (one
The total resources form copper, zinc and lead was estimated from a reworking of the literature. The data was used as input to the integrated systems dynamics model BRONZE, and used to estimate the global supply of these metals and the by-products antimony, indium, germanium, tellurium, cadmium, bismuth and selenium. The runs show that copper, zinc and lead go through peak production around 2050 a
This paper compares the signal-to-noise ratio obtained using an InSb photodiode for infrared (IR) polarization spectroscopy to that obtained using an upconversion detector, and shows a factor 64 improvement by the change. Upconversion detection is based on using sum frequency generation to move the IR optical signal to near-visible wavelengths to improve the sensitivity.
Purpose – The purpose of this paper is to demonstrate that, important as reflexivity is, it does not constitute the gold standard of qualitative research. Instead the author makes a plea for the use of sociological imagination. Design/methodology/approach – The paper makes use of data from the ISI Web of Science database to demonstrate the increasing popularity of the concept of reflexivity. Findi
We have developed an aquatic inelastic hyperspectral lidar with unrestricted focal-depth and enough sensitivity and spatio-temporal resolution to detect and resolve position and behavior of individual sub-millimeter aquatic organisms. We demonstrate ranging with monitoring of elastic echoes, water Raman signals and fluorescence from chlorophyllbearing phytoplankton and dye tagged organisms. The sy
Fluvial geomorphology provides the basis for characterizing complex river networks and evaluating biophysical processes within watersheds. Understanding the spatial organization of morphological features, their influencing processes, and resultant geomorphic diversity in stream networks are important for efficient restoration, river health assessment, and improving our knowledge of the resilience
Semiconductor nanowire solar cells have achieved comparable efficiency to their planar counterparts with substantial reduction of material consumption. Tandem geometry is a path towards even higher efficiency. However, extensive studies are needed to reach this goal. My study started from the building blocks of the materials used in the upper cell, namely GaInP nanowires. The growth and doping con
Digital PCR techniques are ideally suited for accurately quantifying trace amounts of target DNA sequences, such as tumor-derived mutant DNA that is present in the blood circulation of patients with cancer. Here, we describe an approach marrying low-coverage whole-genome sequencing of tumor tissues, to enumerate chromosomal rearrangement breakpoints, together with droplet digital PCR (ddPCR)-based
R&D related foreign direct investments represent a powerful mechanism for cross-border knowledge sharing that can stimulate the process of technological catch-up. However, low-income countries and smaller middle-income countries remain largely excluded from this kind of global flows of knowledge. In this chapter, we discuss the motivations and implications of this type of FDI for low and middl
