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In this paper the problems of organization and representation of concept knowledge are addressed from an autonomous agent perspective. The first part of the paper discusses the question of why an autonomous agent needs concepts at all and what other uses it can make of them. After the necessary and/or desirable functions of concepts have been identified, previous attempts to represent concepts are
The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into
The two most common strategies for verification and validation, inspection and testing, are in a controlled experiment evaluated in terms of their fault detection capabilities. These two techniques are in the previous work compared applied to code. In order to compare the efficiency and effectiveness of these techniques on a higher abstraction level than code, this experiment investigates inspecti
In the water sector, there have been numerous failures in projects aiming at sustainable development and there have been some, but less numerous, examples of successes. However, the most striking observation is the near universal failure to learn from these examples. Somehow, scientists and decision makers have allowed the indications of new approaches and opportunities go undetected because they
Sensing and quantification of biomolecules are becoming increasingly important in medical diagnostics, bioprocess technology and recently in homeland security. The majority of techniques currently employed to interrogate biomolecules require some type of radio-, enzymatic- or fluorescent-labeling. However, there is an increasing awareness of novel techniques in which biomolecules are detected in t
In a pulsed UWB system, either coherent receivers or transmit-reference (TR) receivers can be used to demodulate the signals. For coherent receivers, which are typically based on a Rake Structure, the large number of resolvable multipaths is a major challenge for channel estimation and receiver complexity. TR receivers can effectively collect energy from all the received multipath components with
Popular Abstract in Swedish Mesenteriell ischemi (nedsatt blodcirkulation till tarm och övriga bukorgan) är vanligt förekommande vid ett flertal olika sjukdomstillstånd som t ex blödnings-, septisk och cirkulatorisk chock. Inte minst är tarmen mycket känslig för nedsättning av blodflödet. Tarmskadan, inkluderande dess barriär(skydds-)funktion sker dels under perioden med nedsatt blodförsörjning meIntestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction
Societal safety and sustainability are key challenges in our complex and dynamic world, causing growth in interest of applying the concept of resilience in broader societal contexts. This paper presents a concept of Community Resilience that builds on established theory of Resilience Engineering and operationalises the concept by presenting its purpose, required functions and a way to identify and
Popular Abstract in Swedish En studie av hur glokokortikoider hämmar inflammation Glukokortikosteroider, varav kortison är den mest kända, är hormoner som reglerar många funktioner i kroppen och även används som läkemedel för att dämpa inflammatoriska tillstånd som t.ex. astma och reumatiska sjukdomar. Glukokortikosteroider är mycket potenta läkemedel och används flitigt med mycket goda effekter.The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. In macrophages, the synthetic glucocorticoid dexamethasone (dex) was found to reduce the expression of cPLA2 a
In this thesis I have summarised my work on the analysis and improvement of xylose utilisation by recombinant S. cerevisiae. A metabolic flux model was developed and used to analyse the intracellular fluxes in the recombinant xylose utilising S. cerevisiae TMB 3001 cultivated in chemostat at various dilution rates and xylose/glucose concentrations. Xylose uptake increased with xylose concentration
Emerging wireless sensor and actuator network (WSAN) technology has the potential to enable semi-autonomous air-flow control to improve the aerodynamic performance of aircraft. In this paper, a WSAN topology comprising of multiple linear sensor clusters terminated by actuators is proposed for active flow control. Two interference aware convergecast scheduling strategies are presented and analyzed,
