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Two frameworks are proposed for extremum seeking of general nonlinear plants based on a sampled-data control law, within which a broad class of nonlinear programming methods is accommodated. It is established that under some generic assumptions, semi-global practical convergence to a global extremum can be achieved. In the case where the extremum seeking algorithm satisfies a stronger asymptotic s

Neural transplantation holds promise for focal CNS repair. Owing to the shortage of human donor material, which is derived from aborted embryos, and ethical concerns over its use, animal donor tissue is now considered an appropriate alternative. In the USA, individuals suffering from Parkinson's disease, Huntington's disease, focal epilepsy or stroke have already received neural grafts from pig em

Background: Free and total human kallikrein 2 (hK2) might improve the discrimination between prostate cancer and benign prostatic hyperplasia. Concentrations of hK2 are 100-fold lower than concentrations of prostate-specific antigen (PSA); therefore, an hK2 assay must have a low detection limit and good specificity. Methods: PSA- and hK2-specific monoclonal antibodies were used in solid-phase, two

Let X = (X(t) : t greater than or equal to 0) be a Levy process. In simulation, one often wants to know at what size it is possible to truncate the small jumps while retaining enough accuracy. A useful tool here is the Edgeworth expansion. We provide a third order expansion together with a uniform error bound, assuming third Levy moment is 0. We next discuss approximating X in the finite variation

A method for simultaneous determination of the diffusion and sorption properties of cement-based materials is presented. It is a gravimetric method where one small specimen is exposed to stepwise changes in relative humidity while its mass is being measured. As sorption in cement-based materials is slow, the change in relative humidity to the next level is made before final equilibrium has been re

Background: Standardized techniques to detect HIV-neutralizing antibody responses are of great importance in the search for an HIV vaccine. Methods: Here, we present a high-throughput, high-content automated plaque reduction (APR) assay based on automated microscopy and image analysis that allows evaluation of neutralization and inhibition of cell-cell fusion within the same assay. Neutralization

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglyceri

Popular Abstract in Swedish Bakgrund Kroniskt obstruktiv lungsjukdom (KOL) är en vanlig orsak till död världen över och dödligheten ökar främst bland kvinnor. Patienter med kronisk syrebrist på grund av KOL behandlas med hemsyrgas (LTOT), men har mycket hög dödlighet. Kunskapen är idag bristfällig kring könsskillnader och tidstrender i dödlighet och dödsorsaker, betydelsen av andra sjukdomar (samsBackground Chronic obstructive pulmonary disease (COPD) is a major and rising cause of mortality worldwide, especially in women. Patients with chronic hypoxia owing to COPD are treated with long-term oxygen therapy (LTOT) but have high morbidity and mortality. Knowledge is limited on sex-related differences and time trends in mortality, effects of comorbidity on mortality and whether cardiovascula

In this paper we propose a scheme for test planning and test access mechanism (TAM) design for stacked integrated circuits (SICs) that are designed in a core-based manner. Our scheme minimizes the test cost, which is given as the weighted sum of the test time and the TAM width. The test cost is evaluated for a test flow that consists of a wafer sort test of each individual chip and a package test