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Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

To gain insights into the regulatory mechanisms of hematopoietic stem cells (HSCs), we employed a genome-wide RNAi screen in human cord-blood derived cells and identified candidate genes whose knockdown maintained the HSC phenotype during culture. A striking finding was the identification of members of the cohesin complex (STAG2, RAD21, STAG1, and SMC3) among the top 20 genes from the screen. Upon

Filmhäftet 123

Innehåll: Ledare (Michael Tapper), Geometry of Force: Abel Ferrara och Simone Weil (Tag Gallagher), Lang & Brecht (Robin Wood), Tankar kring filmens estetik (Georg Lukács), Kommentar till Lukács (Jakob J Norberg), Exotisk esteti: Kenji Mizoguchi och Josef von Sternberg (Tim Palmer), Recensionsessä böcker: Mediedidaktikens villkor (Lars Gustaf Andersson), Recensionsessä film: Philip K Dick, the

Solar heating may explain extreme diel flight altitude changes in migrating birds

Great reed warblers, Acrocephalus arundinaceus,1 and great snipes, Gallinago media,2 exhibit a diel cycle in flight altitudes—flying much higher during the day than the night—when performing migratory flights covering both night and day. One hypothesis proposed to explain this behavior is that the birds face additional heating by solar radiation during daytime and hence must climb to very high, an

Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial

Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functiona

Investigation of enzymatic hydrolysis inhibition of sucrose using sugar beet molasses for biorefineries

Behovet av mer miljövänliga lösningar har aldrig varit större än idag. Mängden koldioxidutsläpp ökar ständigt, vilket leder till ökad mängd koldioxid i atmosfären. Vid tillverkning av plast används idag vanligtvis olja som råmaterial, men man kan använda biobaserat råmaterial i stället såsom socker. I Sverige produceras socker av sockerbetor. En restprodukt är då melass en tjock sirapsliknande socMolasses is a low value by-product from sugar production that is usually used for animal feed, bioethanol fermentation, and yeast growth substrate. Even though it is a by-product and most of the sugar have been taken out the molasses still contains a fair amount of sugar that can be used for production of HMF, a biobased platform chemical with many areas of application, for example as a feedstock

Dependence of Degradation Mechanisms in Magnesium Alloys on Grain Orientation and Interfaces in 3D

Idag används stål eller titan som fixtur för benbrott. Dessa måste opereras in, och efter läkning opereras ut igen. En kandidat att ersätta dessa material är Magnesium, vilken naturligt och ofarligt bryts ned i kroppen så en andra operation inte behövs. För att kunna designa en magnesiumlegering vilken kan användas som implantat vid benbrott måste vi förstå hur nedbrytningsprocessen går till. FörMagnesium alloys are promising candidates as biomedical implants. However, a good understanding of their degradation processes is lacking. In this work, degradation in two magnesium alloys were studied in a simple physiological-fluid electrolyte of H2O+0.9wt%NaCl, Mg-5wt%Zn (Z5) & Mg-5wt%Zn-0.3wt%Ca (ZX50). Z5 alloy was studied in two microstructural states, as-cast and as a supersaturated sol

External evaluation 2005

External evaluation of SASNET External evaluation of the Swedish South Asian Studies Network (SASNET) By Carla Risseeuw, Ghanshyam Shah and Lennart Wohlgemuth June 2005 External evaluation of the Swedish South Asian Studies Network (SASNET) By Carla Risseeuw, Ghanshyam Shah and Lennart Wohlgemuth 1. Summary and Conclusions SASNET was created through a grant from Sida/SAREC and Lund’s University in

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/external_evaluation_2005.pdf - 2026-06-19

About us

About us | Saco-S council at Umeå University Hoppa till huvudinnehåll About us Contact Workplace representative Arts and Humanities Medicine Social Sciences Science and Technology Others Work environment representative Calendar Saco-S Umeå universitet Swedish About us Contact Workplace representative Work environment representative Calendar Start > Trustee > Local union work > Local unions > Saco-

https://www.saco.se/en/trustee/local-union-work/local-unions/government-sector/saco-s-radet-at-umea-university/about-us/ - 2026-06-19

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we dem

Intake of different types of red meat, poultry, and fish and incident colorectal cancer in women and men: results from the Malmö Diet and Cancer Study.

Background : Colorectal cancer (CRC) is considered one of the most common forms of cancer in the Western world. High intake of red and processed meat is considered to increase CRC development. Objective : This study examined associations between intake of red meats, poultry, and fish and incident CRC, and if weight status modifies the associations. Design : In the Malmö Diet and Cancer Study, diet

Markavvattningsföretagens påverkan på möjligheten till återvätning av våtmark - Ur aktörernas synvinkel

Återvätning av våtmark hämmas av markavattningsföretag En fjärdedel av Sveriges våtmark är avvattnad och detta kan ha gjorts med hjälp av markavvattningsföretag. Nu vill Sveriges regering återväta våtmarker men markavvattningsföretagen ligger som en blöt filt över processen. Faktum är att de kan vara den enda anledningen till att ett återvätningsprojekt läggs ner. Den absolut mest betydande probleWetlands are one of the most precious ecosystems in the world. They are important be-cause of their high biological diversity and unique properties, such as water purification and carbon sequestration. Yet, wetlands are also one of the most endangered ecosystems due to land draining. In Sweden, wetlands have been drained för centuries due to the lack of arable land. The draining can have been acco

Modelling human rostro-caudal neural patterning with a microfluidic morphogenic gradient

The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient formi

Verkan av passivitet vid avtals ingående

Uppsatsens syfte är att utreda vilka möjligheter det finns att ingå ett avtal trots parts passivitet. Begreppet passivitet används i betydelsen underlåtenhet att agera när part, under en process till synes syftande till att avtal ska ingås, normalt kan förväntas agera genom en positiv viljeförklaring, ett nekande eller ett förtydligande. Innan passivitetsfrågan behandlas närmare presenteras den The purpose of this essay is to investigate the possibilities of entering into a binding agreement despite the passivity of one of the parties. The term passivity is used to denote the lack of action when a party, during a process with the apparent aim of entering into an agreement, typically can be expected to act through a declaration of intent, a refusal or a clarification. Before a closer en

Ifu archive solution 7t mr user

IfU Archive Solution 7T MR.pdf Page 25 of 49 If you have system administrative rights, you may choose whether to see all the projects in the system or only the ones you have membership in, by clicking the checkbox to the left of Show all. When you have clicked on the project of your choice, you will be presented with the project’s directory tree to the left. If there are subdirectories belonging t

https://www.lbic.lu.se/sites/lbic.lu.se/files/ifu_archive_solution_7t_mr_user.pdf - 2026-06-19

EMP Programme Syllabus 2022 2023

1 A Programme Syllabus for the Master of Science in Environmental Management and Policy / Masterprogram i Miljöstrategisk Styrning Programme code: XAMIS Scope: 120 credits Cycle: Second Approved by: Programme Board W Validity: 2022/2023 Date of approval: 21 February 2022 Language of instruction: English 2 1 AIM AND OUTCOMES 1.1 AIM The International Master’s Programme in Environmental Management a

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/2022-05/EMP%20Programme%20Syllabus_2022_2023.pdf - 2026-06-19

Programme Syllabus EMP 2023-2024

1 A Programme Syllabus for the Master of Science in Environmental Management and Policy / Masterprogram i Miljöstrategisk Styrning Programme code: XAMIS Scope: 120 credits Cycle: Second Approved by: Programme Board W Validity: 2023/2024 Date of approval: 13 February 2023 Language of instruction: English 2 1 AIM AND OUTCOMES 1.1 AIM The International Master’s Programme in Environmental Management a

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/2023-02/Programme%20syllabus%20EMP%202023-2024.pdf - 2026-06-19

Programme Syllabus EMP 2024-2025

1 A Programme Syllabus for the Master of Science in Environmental Management and Policy / Masterprogram i Miljöstrategisk Styrning Programme code: XAMIS Scope: 120 credits Cycle: Second Approved by: Programme Board W Validity: 2024/2025 Date of approval: 12 February 2024 Language of instruction: English 2 1 AIM AND OUTCOMES 1.1 AIM The International Master’s Programme in Environmental Management a

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/2024-03/programme%20syllabus%20EMP%202024-2025.pdf - 2026-06-19

Trippelgungbrada 1

15LMNT-nytt 2022:214 TRIPPELGUNGBRÄDA – När klassrummet flyttar utanför skolan Som ett inslag i en lärarlyftskurs i Naturkunskap på Högskolan i Kristianstad genomförde deltagarna en lekplatslaboration som omvandlades till ett miniprojekt på distans. I förra numret av LMNT-nytt presenterades en undersökning av skridskoåkarnas lutning i en konståkningsvinge. Här presenteras ett projekt om krafter i

https://www.nrcf.lu.se/sites/nrcf.lu.se/files/2023-03/trippelgungbrada_1.pdf - 2026-06-19