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Background: Alzheimer's disease (AD) is a neurodegenerative disorder caused by a complex interplay of various factors. However, a satisfactory cure for AD remains elusive. Pharmacological interventions based on drug targets are considered the most cost-effective therapeutic strategy. Therefore, it is paramount to search potential drug targets and drugs for AD. Objective: We aimed to provide novel
Background: In luminal breast cancer, adjuvant CDK4/6 inhibitors (eg, abemaciclib) improve invasive disease-free survival. In patients with T1–2, grade 1–2 tumours, and one or two sentinel lymph node metastases, completion axillary lymph node dissection (cALND) is the only prognostic tool available that can reveal four or more nodal metastases (pN2–3), which is the only indication for adjuvant abe
This article investigates strategic communication in the context of the wider adoption of “campaign” approaches to public diplomacy at the Foreign & Commonwealth Office. The three case studies are the visit of Pope Benedict XVI to the United Kingdom, the marriage of HRH Prince William to Kate Middleton, and Queen Elizabeth II’s visit to Ireland. The analytical framework seeks to situate strate
Recent years have seen tremendous effort in the development of approaches with which to obtain quantum mechanics/molecular mechanics (QM/MM) free energies for reactions in the condensed phase. Nevertheless, there remain significant challenges to address, particularly, the high computational cost involved in performing proper configurational sampling and, in particular, in obtaining ab initio QM/MM
Future climate scenarios are predicting considerable threats to sustainable maize production in arid and semi-arid regions. These adverse impacts can be minimized by adopting modern agricultural tools to assess and develop successful adaptation practices. A multi-model approach (climate and crop) was used to assess the impacts and uncertainties of climate change on maize crop. An extensive field s
Imagine a world in which damaged parts of the body – an arm, an eye, and ultimately a region of the brain – can be replaced by artificial implants capable of restoring or even enhancing human performance. The associated improvements in the quality of human life would revolutionize the medical world and produce sweeping changes across society. In this chapter, we discuss several approaches to the f
Adolescence and emerging adulthood are key developmental stages with high risk for trauma exposure and the development of mental and substance use disorders (SUDs). The aim of this study was to compare the clinical profiles of adolescents (aged 12-17 years) and emerging adults (aged 18-25 years) presenting for treatment of posttraumatic stress disorder (PTSD) and SUD. Design/methodology/approach:
Borderline Personality Disorder (BPD) has largely been associated with self-harm and chronic suicidality, despite the fact that these behaviours comprise only one diagnostic criterion. Treatments for self-harm are mostly indicated for individuals with BPD. Emerging literature suggests that youth with histories of depression are at risk of both self-harm and completed suicide. For individuals with
An investigation concerning a group of paintings sharing a common motif. The motif is the Madonna with the infants Jesus and Saint John, the Infant Jesus holding a goldfinch. Rapahel's version of the painting, in the Uffizi, is discussed in relation to a similar version of the motif that appeared in Sweden in the 1990's.
In a recent paper we presented a procedure for optimal analyticalcontrol of several deformable mirrors based on only the measured guidestar wavefronts. The expected performance was evaluated for variousguide star configurations using up to three deformable mirrors. Forsimplicity the guide stars were assumed to be infinitely distant. Inthis paper we address the effect of using laser guide stars in
This master thesis aims to investigate the visual characteristics of Late Bronze Age tholos tombs in the region of Messenia, Greece by comparing tholos tombs from two study areas: the Pylian hinterlands and the Soulima Valley. The study utilises cost surfaces and viewsheds created in a GIS-environment as heuristic devices to do so. With the common assumption that the tholos tombs were erected as v
Tetra Pak is a large scale organization that provides its customers with a food packaging solution based on laminated carton board in various package formats. The packaging material is produced in more than 50 converting factories represented world wide. The production develops the material in roll form that are loadable in the filling machines. Each roll arrives to the filling site with a barcode
In this thesis, a fault detection and diagnosis system is developed for the Crazyflie 2.1 unmanned aerial vehicle. Different types of faults are investigated and suitable methods and tests are implemented. The system is mainly developed for the lighthouse positioning, but the tests and methods are generic and suitable for other parts of the Crazyflie eco-system. For the faults investigated, differ
The increasing focus on lithium-ion batteries (LIBs) in the context of electrification of transport sector has raised concerns about their high costs, resource and energy demands, environmental impact, and social supply chain risks. To address these challenges and maximize the value of LIBs throughout their lifecycle, circular economy (CE) strategies, such as reusing and repurposing, are being exp
Fresh water resources face risks due to urbanisation, economic development, and climate change (CC). Many small and medium-sized cities (SMCs) are particularly vulnerable to these risks due to the lower resource capacity required to mitigate them. Nature-based Solutions (NbS) for water resource management (WRM) are promising to tackle these issues in urban areas while providing extra benefits to s
