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Many common diseases are known to have genetic components, but since they are non-Mendelian, i.e. a large number of genetic factors affect the phenotype, these components are difficult to localize. These traits are often called complex and analysis of siblings is a valuable tool for mapping them. It has been shown that the power of the affected relative pairs method to detect linkage of a disease
Organic farming may contribute substantially to future agricultural production worldwide by improving soil quality and pest control, thereby reducing environmental impacts of conventional farming. We investigated in a comprehensive way soil chemical, as well as below and aboveground biological parameters of two organic and two conventional wheat farming systems that primarily differed in fertiliza
Originally cloned from hematopoietic stem cell (HSC) populations and its ligand being extensively used to promote ex vivo HSC expansion, the FMS-like tyrosine kinase 3 (FLT3; also called FLK2) receptor and its ligand (FL) were expected to emerge as an important physiologic regulator of HSC maintenance and expansion. However, the role of FLT3 receptor and ligand in HSC regulation remains unclear an
Nuklearmedicinsk bildtagning med hjälp av radiofarmaka är ett viktigt verktyg för att studera biologiska processer och humansjukdomar. Bildtagning sker ofta med en detektor i kombination med en kollimator. En typ av kollimering är pinnhålskollimering, där ett pinnhål i ett opakt material placeras mellan en källa och en detektor. Pinnhålet fyller samma funktion som en optisk lins då emitterade fotoThe focus of this dissertation is the use of pinhole collimation in Nuclear Medicine. A pinhole is a single aperture in an opaque material that is placed between the detector and source of interest, and photons must pass through the hole to reach the detector. The choices of pinhole parameters, e.g. the pinhole material and size of the opening, are closely linked to the performance of the detector
This article seeks to explain what policy approaches and policy measures are best suited for promoting new regional industrial path development and what needs and possibilities there are for such policy to change and adapt to new conditions in order to remain efficient. The article departs from the notion of Smart Specialization and discusses how regional strategies that are inspired by this appro
The global extraction of minerals is commonly located in areas populated by indigenous people; and while conflicts between multinational corporations and local activists and indigenous people are widespread today, the understanding of their dynamics are lacking. The Swedish government’s encouragement to an expanding mining industry has caused resistance due to environmental and social implications
A methodology for designing and scaling the performance and thermal characteristics of electric powertrain components is presented. This methodology is aimed at finding optimum component combinations based on a set of requirements. Both drive-cycle performance and specific operating modes such as curb-climbing and maximum wheel speed are considered. This allows the selection of electrical machine
Human intrahepatic lymphocytes are enriched in CD1d-unrestricted T cells coexpressing NKR. Although the origin of this population remains controversial, it is possible to speculate that the hepatic microenvironment, namely epithelial cells or the cytokine milieu, may play a role in its shaping. IL-15 is constitutively expressed in the liver and has a key role in activation and survival of innate a
Background & Aims Predniso(lo)ne, alone or in combination with azathioprine, is the standard-of-care (SOC) therapy for autoimmune hepatitis (AIH). However, the SOC therapy is poorly tolerated or does not control disease activity in up to 20% of patients. We assessed the efficacy of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy for patients with AIH. Methods We performed a r
Humans have dramatic, diverse and far-reaching influences on the evolution of other organisms. Numerous examples of this human-induced contemporary evolution have been reported in a number of ‘contexts’, including hunting, harvesting, fishing, agriculture, medicine, climate change, pollution, eutrophication, urbanization, habitat fragmentation, biological invasions and emerging/disappearing diseas
Background Individuals without occupational exposure are exposed to mercury (Hg) from diet and dental amalgam. The kidney is a critical organ, but there is limited information regarding the relationship between Hg in kidney (K-Hg), urine (U-Hg), blood (B-Hg), and plasma (P-Hg). Objectives The aim was to determine the relationship between K-Hg, U-Hg, B-Hg, and P-Hg among environmentally exposed ind
Pulsed Doppler (PW) and tissue Doppler imaging (TDI) measurements are part of every echocardiography examination for evaluation of left ventricular (LV) diastolic function and filling pressure. The purpose of this study was to summarize published data on normal values for PW and TDI measurements. A PubMed search was performed on the 10th of October 2016 to identify relevant articles. Studies were
This article investigates strategic communication in the context of the wider adoption of “campaign” approaches to public diplomacy at the Foreign & Commonwealth Office. The three case studies are the visit of Pope Benedict XVI to the United Kingdom, the marriage of HRH Prince William to Kate Middleton, and Queen Elizabeth II’s visit to Ireland. The analytical framework seeks to situate strate
The purpose of this study was to perform an initial investigation of the possibility to determine breast cancer growth rate with 14C bomb-pulse dating. Tissues from 11 breast cancers, diagnosed in 1983, were retrieved from a regional biobank. The estimated average age of the majority of the samples overlapped the year of collection (1983) within 3σ. Thus, this first study of tumour tissue has not
Representation of atmospheric transport is a major source of error in the estimation of greenhouse gas sources and sinks by inverse modelling. Here we assess the impact on trace gas mole fractions of the new physical parameterizations recently implemented in the atmospheric global climate model LMDz to improve vertical diffusion, mesoscale mixing by thermal plumes in the planetary boundary layer (
Aim: Attention-deficit/hyperactivity disorder (ADHD) is the most common diagnosis within child- and adolescent psychiatry. Waiting lists and delayed care are major issues. The aim was to evaluate if standardized care (SC) for assessment and treatment of uncomplicated ADHD would reduce resource utilization and increase satisfaction with preserved improvement within the first year of treatment. Meth
The eyelids are susceptible to a number of skin cancers which are challenging to excise radically without sacrificing excessive healthy tissue. The way in which a tumor is delineated preoperatively has not changed significantly over the past century. The aims of the work presented in this thesis were to investigate two novel non-invasive techniques for diagnosing and delineating skin tumors.Extend
