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In polaritons, the properties of matter are modified by mixing the molecular transitions with light modes inside a cavity. Resultant hybrid light-matter states exhibit energy level shifts, are delocalized over many molecular units, and have a different excited-state potential energy landscape, which leads to modified exciton dynamics. Previously, non-Hermitian Hamiltonians have been derived to des
ObjectiveTo determine the feasibility of a digitally automated population-based programme for organised prostate cancer testing (OPT) in Southern Sweden.Patients and MethodsA pilot project for a regional OPT was conducted between September 2020 and February 2021, inviting 999 randomly selected men aged 50, 56, or 62 years (y). Risk stratification was based on PSA, PSA density (PSAD), and biparamet
Reducing the excitation threshold to minimize the Joule heating is critical for the realization of perovskite laser diodes. Although bound excitons are promising for low threshold laser, how to generate them at room temperature for laser applications is still unclear in quasi-2D perovskite-based devices. In this work, via engineering quasi-2D perovskite PEA2(CH3NH3)n-1PbnBr3n+1 microscopic grains
Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functional variants to confirm
Over the past two decades, intensive research efforts have been devoted to suppressions of Auger recombination in metal-chalcogenide and perovskite nanocrystals (PNCs) for the application of photovoltaics and light emitting devices (LEDs). Here, we have explored dodecahedron cesium lead bromide perovskite nanocrystals (DNCs), which show slower Auger recombination time compared to hexahedron nanocr
Current visual text analysis approaches rely on sophisticated processing pipelines. Each step of such a pipeline potentially amplifies any uncertainties from the previous step. To ensure the comprehensibility and interoperability of the results, it is of paramount importance to clearly communicate the uncertainty not only of the output but also within the pipeline. In this paper, we characterize t
Cartilage oligomeric matrix protein (COMP) was recently implicated in the progression of breast cancer. Immunostaining of 342 prostate cancer specimens in tissue microarrays showed that COMP expression is not breast cancer-specific but also occurs in prostate cancer. The expression of COMP in prostate cancer cells correlated with a more aggressive disease with faster recurrence. Subcutaneous xenog
Different levels of user involvement in product design range from understanding user needs to co-designing with users. Previous research shows older patients face difficulties to handle the medication packaging. Yet the participation of older patients in pharmaceutical packaging design is underexplored. The purpose of this study is to explore the role of older patients in the design and developmen
During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34(+) cells. The resulting transcriptional hierarchy showed a continuum of endothelial and hematopoietic signatures. At the interface of
Neoadjuvant chemotherapy (NACT) is offered to an increasing number of breast cancer (BC) patients, and comprehensive monitoring of treatment response is of utmost importance. Several imaging modalities are available to follow tumor response, although likely to provide different clinical information. We aimed to examine the association between early radiological response by three conventional imagi
To evaluate the diagnostic yield of the ECG criteria for ST-elevation myocardial infarction in a large cohort of emergency department chest pain patients, and to determine whether extended ECG criteria or reciprocal ST depression can improve accuracy. Design: Observational, register-based diagnostic study on the accuracy of ECG criteria for ST-elevation myocardial infarction. Between Jan 2010 and
We study the behaviour of an interacting particle system, related to the Bak–Sneppen model and Jante’s law process defined in Kennerberg and Volkov (Adv Appl Probab 50:414–439, 2018). Let N≥ 3 vertices be placed on a circle, such that each vertex has exactly two neighbours. To each vertex assign a real number, called fitness (we use this term, as it is quite standard for Bak–Sneppen models). Now f
Introduction and discussion of Stephen Wolfram's enormous book "A New Kind of Science" from 2002.
Cancer cells display acoustic properties enabling acoustophoretic separation from white blood cells (WBCs) with 2–3 log suppression of the WBC background. However, a subset of WBCs has overlapping acoustic properties with cancer cells, which is why label-free acoustophoretic cancer cell isolation needs additional purification prior to analysis. This paper reports for the first time a proof of conc
The purpose of the article is to describe and compare the purchasing process for advanced versus basic logistics services. Further some specific observations are presented from the procurement of advanced third-party logistics services, with respect to service definitions, providers evaluations and contracts. The purchasing process of logistics services will in the future need to be more different
En hjälpsam tvilling ska minska svinnet av läkemedel Tänk om du skulle behöva stoppa i dig en massa oönskade, kanske rentav farliga ämnen varje gång du var sjuk. Låter inte särskilt hälsosamt va? Det är just därför som upprening av läkemedel är viktigt. Att ta fram rena läkemedel är inte helt enkelt och kan leda till att läkemedel behöver kastas bort. Genom ett examensarbete vid Lunds UniversitetPreparative chromatography is an important process step for separation and purification of fine chemicals, pharmaceuticals, and other biotechnical products. The technique mainly used in the pharmaceutical and fine chemistry industries is single-column batch chromatography (BC). The major drawback of BC is the trade-off between product purity and process performance. A high purity of the product co
I inköpsfunktionen för indirekt material och tjänster finns, för fallstudieföretagen, en kategori som ofta benämns Professionella tjänster eller dylikt. I denna övergripande kategori är konsult- och bemanningstjänster ofta underkategorier. Gränsdragningen mellan konsulttjänsterna och bemanningstjänster har dock visat sig otydliga och problematiken verkar främst finnas för konsult- och bemanningstjIn the purchasing funktion of indirect materials and services there is, for the case study companies, a category often referred to as Professional Services. In this overall category consultancy and temporary labour services are subcategories. Drawing the line between consultancy and temporary labour services has been proved unclear and the problems seem to mainly concern IT services. A proposal on
Global Witness är en icke-statlig organisation som jobbar med att hitta samband mellan naturresurser, korruption och mänskliga rättigheter. År 1998 släppte Global Witness en rapport som avslöjade den fruktansvärda sanningen bakom de dyrbara diamanter som västvärlden köpte i sina butiker. Benämningen på denna sortens diamanter kom att bli blodsdiamanter. Global Witness insåg snabbt att någonting be
En studie över hur naturens samhällsviktiga ”tjänster” kommuniceras i Riksbyggens byggprocess Framför dig har du en sammanfattande text. Den ämnar ge en övergripande bild av en studie vars innehåll belyser hur de, för människans välstånd, så viktiga ”tjänster” som naturens ekosystem förser våra samhällen med, kommuniceras genom ett byggföretags process för bostadsproduktion. Dessa tjänsters brukaThe purpose of this master´s thesis was to evaluate how the data, generated through Riksbyggens´s tool for analyzing ecosystem services in housing projects, is communicated and used through the stages of Riksbyggen´s housing development process. Furthermore, the purpose was to use this information to suggest how Riksbyggen can improve the communication related to the inclusion of ecosystem service
Innovation är ett vidkänt koncept som har fått ökad betydelse i dagens organisationer. Uppmärksamhet har framförallt riktats till de initiala faserna av innovationsprocessen, kallade Fuzzy Front End (FFE). Att hantera FFE effektivt har blivit nödvändigt i utvecklingen av nya innovativa produkter, eftersom det kan minska cykeltider och kostnader relaterat till produktutvecklingen. Det är dock svårtInnovation is a widely known concept which has received increased importance in today's organizations. Attention has especially been directed to the initial phases of the innovation process, commonly referred to as the Fuzzy Front End (FFE). Managing the FFE effectively, has become essential in the development of innovative products, since it can reduce cycle times and costs related to product
