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In order to describe a novel approach for the clinical study of metastases, we provide here age-specific incidence and survival data for cancer of unknown primary (CUP). Metastases in various organs are found at CUP diagnosis, which have implications for prognosis, and we hypothesize similar prognostic implications for metastases found at diagnosis of primary cancers. We identified 33,224 CUP pati
Objective and design: Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as long-COVID). The mechanisms underlying long-COVID fatigue are unknown. We hypothesized that the development of long-CO
Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly l
Charles Tilly was instrumental in launching the comparative study of contentious politics through key contributions delineating and defining the subject matter. But his input is epistemological as well as theoretical and substantive. What characterizes his epistemology is a realist mechanistic explanation rendering mechanisms tools of both explanation and comparison. Employing the realist perspect
Many-electron systems undergo a collective Larmor precession in the presence of a magnetic field. In a paramagnetic metal, the resulting spin wave provides insight into the correlation effects generated by the electron-electron interaction. Here, we use dynamical mean-field theory to investigate the collective Larmor precession in the strongly correlated regime, where dynamical correlation effects
The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters afte
Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and
Introduction: Health problems in people with intellectual and developmental disability (IDD) are traditionally known to be common in adults of all age, with at least twice as many health problems in this group as the general ageing population. In addition, there is considerable international evidence indicating an earlier death for people with IDD compared to the general population, exacerbated by
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous proble
Objectives: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. Patients and methods: Data were extracted from 59 studies, with 16 studies i
Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 stool BAs in two population-based cohorts (TwinsUK, n = 2,382; ZOE PREDICT-1, n = 327) and assess changes post-bariatric surgery and after nutritional
Paleoklimatologi – läran om hur klimatet utvecklats genom jordens historia – ger oss referensramar för att sätta dagens klimat och möjliga framtida klimatförändringar i ett historiskt perspektiv. Till exempel visar nya analyser av historiska klimatarkiv att för norra halvklotet var perioden 1983-2012 sannolikt den varmaste på 1400 år. Vi ser även att vid den senaste värmeperioden, för 125 000 år s
This article contains an overview of the current proposals of converging IP-networks with PSTN. We describe Parlay and Open Service Access( OSA), two of the most promising architecture.
Healthcare is under pressure and a development towards a more integrated and efficient healthcare requires better communication and collaboration across boundaries. This thesis is about facilitation of change process in the healthcare context with learnings from an authentic project, carried out with the clinic for reconstructive plastic surgery at the Karolinska University Hospital. The methodolo
Currently, the consumer decision-making is influenced by an increase of technological adoption, called multi-channel retailing, which can be defined as a retailer using a combination of integrated channels for promoting and selling products and services. Since there is a lack of knowledge about how the consumer decision-making in this context looks like, the purpose of the study is to redress the
In 2003, the Kimberley Process, a public-private partnership gathering governments, the diamond industry and several civil society organizations, entered into force. This international scheme, aiming at fighting against conflict diamonds, imposed export bans on diamonds from the Marange Fields in the Eastern part of Zimbabwe and from the Central African Republic. Indeed, evidence of violations of
Ett koordinerat samarbete och tydlig kommunikation utgör grunden för en välfungerande projektering av ett byggprojekt. I det traditionella tillvägagångssättet utförs arbetet sekventiellt, där projektet passerar mellan de inblandade parterna i turordning. Detta linjära arbetsflöde leder ofta till fragmentering av projektdata och svårigheter att bibehålla en gemensam förståelse mellan inblandade parA coordinated collaboration and clear communication forms the foundation for a well-functioning construction project. In the traditional approach, the work is carried out sequentially, where the project is passed on from one involved party to the next. This linear work flow often leads to fragmentation of work data and difficulties in maintaining a common understanding of the project, which in tur
Title: Stickering of Food Products at IKEA–Improving a Process Through Learning from Others; Increasing process maturity to ensure future performance Authors: John Nyqvist and Victoria Vernet Supervisors: Eva Berg, Department of Industrial Management and Logistics, Faculty of Engineering, Lund University Problem description: Stickering has been used at IKEA for a long time to create compliant f
