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Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development an

INTRODUCTION: Sexual life is important for many people and may be limited by breathlessness. We evaluated associations between breathlessness and individuals' perceived satisfaction with sexual lives and explored mediating factors in this relationship. METHODS: A cross-sectional, online, population-based survey of Australian adults with key demographics (age, sex, rurality, state/territory) reflec

Background: Long-term recovery following critical COVID-19 has not been sufficiently studied. Objective: The primary objective was to describe changes in functional outcome and Health-Related Quality of Life (HRQoL) between 3 and 12 months in critically ill COVID-19 survivors. The secondary objective was to investigate factors associated with good functional outcome and HRQoL at 12 months. Methods

To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI an

Objectives: To evaluate the feasibility of AI-assisted reading of prostate magnetic resonance imaging (MRI) in Organized Prostate cancer Testing (OPT). Methods: Retrospective cohort study including 57 men with elevated prostate-specific antigen (PSA) levels ≥3 µg/L that performed bi-parametric MRI in OPT. The results of a CE-marked deep learning (DL) algorithm for prostate MRI lesion detection wer

The Green Revolution in Asia from the early 1960s is defined as a process driven by governments in pursuit of self-sufficiency in food grains. The process was market-mediated and smallholder based and can be dated to the early 1960s with the Nobel Prize Laureate, Norman Borlaug’s research on high-yielding dwarf wheat in Mexico and later spread to rice and number of countries in South East and Sout

By Timo Minssen (CeBIL, UCPH), Sara Gerke & Carmel Shachar A recent US lawsuit highlights crucial challenges at the interface of data utility, patient privacy & data misuse The huge prospects of artificial intelligence and machine learning (ML), as well as the increasing trend toward public-private partnerships in biomedical innovation, stress the importance of an effective governance and

Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of t

BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and ao

BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this syst

BACKGROUND: Kinetic energy (KE) of intracardiac blood flow reflects myocardial work spent on accelerating blood and provides a mechanistic window into diastolic filling dynamics. Diastolic dysfunction may represent an early stage in the development of heart failure (HF). Here we evaluated the hemodynamic effects of impaired diastolic function in subjects with and without HF, testing the hypothesis

Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as well. To develop and evaluate algorithms and neural networks that perform instance or semantic segmentation for detecting nuclei, high quality anno

Background: P-wave indices reflect atrial abnormalities contributing to atrial fibrillation (AF). We aimed to assess a comprehensive set of P-wave characteristics for prediction of incident AF in a population-based setting. Methods: Malmö Preventative Project (MPP) participants were reexamined in 2002–2006 with electrocardiographic (ECG) and echocardiographic examinations and followed for 5 years.

Popular Abstract in SwedishVad är barnets bästa i en domstolsprocess? Hur skall barns behov och intressen tillvaratas under utredningsarbete och beslut, och av vem? I vilken utsträckning skall barn få komma till tals, och varför? Under senare år har barns rättsliga ställning inom olika områden tilldragit allt större intresse inom rättsvetenskapen, bland rättstillämpare och hos allmänheten. SverigeThis dissertation deals with the question of the child´s legal status in legal proceedings concerning its own person. Special problems that may arise in investigations concerning the situation of the child and in decisions on measures to be taken in the best interest of the child are also examined. The Care of Young Persons Act (1990:52) constitutes the framework of this study. According to the Ac

This article is translated and in a shorter version published in English, with the titel: Family Law and Social Law; a Reciprocal Dependency in a Comparative Perspective, International Journal of Law, Policy & the Family nr 1/2006, s. 44-54. This Swedish chapter is more extensive.

Popular Abstract in Swedish Vävnadskallikrein (VK) är ett äggvitespjälkande protein som dels kan aktivera vävnadsnedbrytande enzymer som kollagenas och gelatinas och dels spjälkar kininogen till kininer (bradykinin och kallidin). Via bindning till speciella kininreceptorer (B2 receptorer) som finns överallt i kroppen, styr kininerna olika processer i de flesta av kroppens organ och vävnader såsom Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. A large release of tissue kallikrein from the pancreatic gland

Customer service plays an important role for the competitive strength in the market place. Customer service is however also a concern on the supply side of the company in the sense that assessing, selecting and developing suppliers to improve their customer service can make them contributing to the competitiveness of the company. It is from the latter perspective that this research has been carrie

Background Trials of imatinib have provided evidence of activity in adults with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (ALL), but the drug's role when given with multidrug chemotherapy to children is unknown. This study assesses the safety and efficacy of oral imatinib in association with a Berlin-Frankfurt-Munster intensive chemotherapy regimen and allo geneic stem-cell tr

This paper reports on research to estimate leaf area index (LAI) in Swedish forests with satellite sensor data. The study is part of a research programme that aims at generating input data for process-oriented forest carbon models. Field-work was carried out in two areas in Sweden about 530 km apart, in the nemoral and boreo-nemoral forest regions. Various ways of estimating LAI in the field were