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Objective:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. Methods:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (M
Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important
This paper reports on design studies concerning a moderator concept which aims to maximize the time averaged flux. The idea is to provide neutron spectra showing two clear maxima, with peaks at (similar to 1 angstrom) and (similar to 2.5 angstrom) arising from leakage from both cryogenic and thermal moderators. Such a concept known as a bi-spectral moderator (Mezei, 2006 [1]) while proven on a rea
Coordination during disaster recovery is one of the most neglected areas of disaster risk management, as the majority of literature on coordination focuses on disaster response. The purpose of the study is to investigate the factors affecting coordination for long-term recovery. For this purpose, the study uses semi-structured interviews with different actors involved in the recovery process of th
Partially premixed combustion has the potential of high efficiency and simultaneous low soot and NOx emissions. Running the engine in PPC mode with high octane number fuels has the advantage of a longer premix period of fuel and air which reduces soot emissions, even at higher loads. The problem is the ignitability at low load and idle operating conditions. The objective is to investigate the use
The 1920s saw a significant exchange between eugenicists in Swedenand the young Soviet state. Sweden did not take part in World War I, and duringthe years following immediately upon the Versailles peace treaty, Swedishscholars came to serve as an intermediary link between, on the one hand, SovietRussia and Weimar Germany, and, on the other hand, Western powers. Swedisheugenicists organized confere
A set of three dedicated triggers designed to detect long-lived neutral particles decaying throughout the ATLAS detector to a pair of hadronic jets is described. The efficiencies of the triggers for selecting displaced decays as a function of the decay position are presented for simulated events. The effect of pile-up interactions on the trigger efficiencies and the dependence of the trigger rate
The scope of this paper is to test the predictive capabilities of different evacuation modelling approaches to simulate tunnel fire evacuations. The study is based on the a priori modelling (prior to the experiments) vs a posteriori modelling (after the data collection stage) of a set of tunnel evacuation experiments performed in a tunnel in Stockholm, Sweden. Different degrees of modelling sophis
Popular Abstract in Swedish Mögel i byggnader är ett vanligt problem som kan orsaka en dålig innemiljö och påverka hälsan hos de personer som vistas i byggnaden. Kostnaderna för att åtgärda problemen kan vara omfattande. Att redan vid planeringsstadiet av en byggnad ta hänsyn till risker för mögelväxt kan leda till minskat antal mögelskador i framtiden och ett mer hållbart byggande. Mögelväxt är The susceptibility to mould growth varies between building materials. The factors that most affect mould growth, the relative humidity (RH) and temperature also vary in different parts of buildings. One way of preventing the growth of mould in buildings is therefore to choose building materials that can withstand the expected conditions. It is thus crucial that data are available to allow the corr
Single photons detected by the DELPHI experiment at LEP2 in the years 1997-2000 are reanalysed to investigate the existence of a single extra dimension in a modified ADD scenario with slightly warped large extra dimensions. The data collected at centre-of-mass energies between 180 and 209 GeV for an integrated luminosity of similar to 650 pb(-1) agree with the predictions of the Standard Model and
During the last several decades, improvements in diagnostic skills and in the treatment of children with cancer have substantially increased the number of long term survivors of childhood cancer. Treatment of children with cytostatic drugs is known to create a range of late adverse effects. Among these are damage to certain structures of the inner ear and hearing impairment. In children, a hearing
Freshwater ecosystems in the central Andes provide critical ecosystem services (ES), including water purification, baseflow regulation, groundwater recharge, and cultural and recreational benefits. However, these high-mountain systems are increasingly threatened by changing land use, climate variability, and accelerating pressure on water resources. Understanding local willingness to pay for conse
The recent events of piracy, especially in the Gulf of Aden raised the concerns of the international community, shipping businesses as well as the marine insurance industries. The drastic increase in piratical incidents and the costs associated with them started a discussion as to the piracy coverage under modern marine insurance policies. Piracy has oscillated through history between being treate
Nynas Petroleum is one of the world´s largest producers of naphthenic specialty oils. They have refineries in several parts of the world and their largest production facility is situated in Nynäshamn, Sweden. They also have oil depots in all continents and their largest depot is located in Antwerp, Belgium. In the beginning of 2007 Nynas introduced a new type of transformer oils, called Nova grade
Today’s marketplace is increasingly growing more competitive as production accelerates and products multiply. Therefore, competing organizations have shifted their focus from solely developing the best product, to building value and competitiveness into the employees. As a result, the concept ‘Employee Engagement’ has received a lot of attention during the 21th century. However there still remain
We investigated intracapsular pressure and elasticity of the hip joint capsule in osteoarthritis. HOOS hip score, sonography of the hip joint, and radiographic assessment of osteoarthritis were performed in 31 patients before total hip arthroplasty. The intracapsular hydrostatic pressure was measured perioperatively, and 0.9% saline solution was then injected in the hip joint, 1 mL at a time with
Objective. The first changes in the diabetic kidney are glycogen deposits in the epithelial cells of the thick ascending limb of Henle. These cells produce Tamm-Horsfall protein (THP). Is low excretion of THP associated with the development of renal insufficiency or cardiovascular disease? Material and methods. Urine samples were collected at baseline in patients with type 1 (n=131) and type 2 (n=
The Nordic medical birth registers have long been used for valuable clinical research. Their collection of data for more than four decades offers unusual possibilities for research across generations. At the same time, serum and blotting paper blood samples have been stored from most neonates. Two large cohorts (approximately 100000 births) in Denmark and Norway have been described by questionnair
We review some recent results on the exact asymptotics of the components in the inhomogeneous random graph models of rank 1. We discuss the relevance of these results to the analysis of random walk on random graphs.
