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The healthcare systems of today are facing large challenges, with increasing amounts of patients and overworked hospital staff. Prostate cancer and Alzheimer’s disease are two of the most prevalent diseases, with incidence numbers expected to rise over the coming decade. Medical imaging plays a central role in current diagnostic procedures for these diseases, enabling the potential use of machine-

Background: Magnetic resonance imaging (MRI) is recommended by guidelines to evaluate the severity of brain ischemia after cardiac arrest for functional outcome prediction. However, standardized assessment criteria are lacking. We have developed a semi-quantitative Cardiac Arrest Brain Ischemia (CABI) score to assess the extension of brain ischemia on MRI. Objectives: To evaluate the prognostic pe

The Artificial Intelligence (AI) Act is a relatively new regulation set out in the European Union (EU). It lays out various requirements for AI systems that are placed on the market in the EU. This paper provides a critical and differentiated view of its requirements from a software engineering perspective. A detailed analysis of the legal document shows what requirements are set out for different

This paper addresses the time-optimal path-tracking problem for redundant manipulators. By integrating path-velocity control into existing task-space robot controllers, the task-space motion can be dynamically scaled to satisfy the torque constraint under both kinematic and dynamic uncertainties. Numerical simulations and experiments demonstrate that trajectory feasibility and path-tracking accura

Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. Methods: This was a post hoc analysis of the TTM2-trial,

Software analytics (SA) is often proposed as a tool to support software engineering (SE) tasks. Several secondary studies on SA have been published, some published within the same calendar year. This presents an opportunity to take a meta-perspective and examine how the field of SA has been conceptualized and synthesized so far. By analyzing how SA is defined, which topics are emphasized, what sea

This paper addresses the path-tracking problem of time-optimal trajectories under model uncertainties, by proposing a real-time predictive scaling algorithm. The algorithm is formulated as a convex optimization problem, designed to balance the trade-off between improving feasibility and time optimality of a trajectory. The predicted trajectory is scaled based on the presence of path segments that

In this issue, “25 Years Ago” revisits the article “Out of Control Because of Harmonics: An Analysis of the Harmonic Response of an Inverter Locomotive,” by Erik Möllerstedt and Bo Bernhardsson, in IEEE Control Systems Magazine, vol. 20, no. 4, pp. 70–81. Below is an excerpt from the article.

This study investigates how changes in temperature affect the secondary organic aerosol (SOA) phase state. SOA was formed by α-pinene ozonolysis in an atmospheric simulation chamber at temperatures (T0) in the range of 257–283 K at RH0< 20%. After more than 14 h of SOA aging, one or more heating and cooling ramps were performed. Upon heating, we observe that the onset of evaporative SOA shrinkage

Distributed massive multiple-input multiple-output (D-MIMO) has been identified as a promising technology to meet the service requirements of 6 G wireless networks and beyond. The coordination between a massive number of distributed antennas introduces stiff challenges and requires a substantial amount of computing resources that must be put together with careful algorithm-architecture codesign. T

Human–robot collaboration (HRC) in manufacturing environments requires that physical safety can be guaranteed. Control methods that implicitly regulate the interaction forces between a controlled robot and its environment, such as impedance control, are often used for safety in HRC. However, these methods could be complemented by restricting the robot operational space for additional safety guaran

In this paper, an iterative learning strategy was developed to improve trajectory tracking for an impedance-controlled robot manipulator. In this learning strategy, an update law was proposed to modify the Cartesian reference of an impedance controller. Also, the conditions that ensure its convergence considering the dynamics of the robot were derived. Finally, an experimental evaluation was perfo

The paper present a parallel implementation of an image processing algorithm for the on-line, non-destructive quality assurance of the non-woven, fibrous web materials. The task of the algorithm is to compute the material microstructure descriptors. The premise underlying this work is that the microstructure determines the performance of the material and characterization of the microstructure may

A homoleptic organometallic FeIV complex that is stable in both solution and in the solid state at ambient conditions has been synthesized and isolated as [Fe(phtmeimb)2](PF6)2 (phtmeimb=[phenyl(tris(3-methylimidazolin-2-ylidene))borate]−). This FeIV N-heterocyclic carbene (NHC) complex was characterized by 1H NMR, HR-MS, elemental analysis, scXRD analysis, electrochemistry, Mößbauer spectroscopy,

Background: Acute coronary syndromes most commonly arise from thrombosis of lipid-rich coronary atheromas that have large plaque burden despite angiographically appearing mild. Objectives: This study sought to examine the outcomes of percutaneous coronary intervention (PCI) of non–flow-limiting vulnerable plaques. Methods: Three-vessel imaging was performed with a combination intravascular ultraso

The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1 expression on pathobiology and clinical response to statins in breast cancer needs clarification. 27HC is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27HC also acts as an endogenous selective estrogen receptor (ER) modulator capable of increas

Background: We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 °C and 36 °C) on serum levels of S100. Methods: This is a substudy of the Target Temperature Management after Out-of-Hospital Cardiac Arrest (TTM) trial. Serum levels of S100 were measured a posteriori

Although recommended by the Kidney Disease Improving Global Outcomes, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPICR) creatinine equation was not targeted to estimate glomerular filtration rate (eGFR) among older adults. The Berlin Initiative Study (BIS1CR) equation was specifically developed in older adults, and the Lund-Malmö revised (LMRCR) and the Full Age Spectrum (FASCR) eq

This study aimed to investigate self-reported physical activity levels, perceived body appearance, and body functioning in relation to perceived wellbeing among adolescents. A cross-sectional survey was performed in four upper secondary schools in one municipality in southern Sweden. Data were obtained from questionnaires completed by 1,491 adolescents (55.4% females; median age 16; range 15–17 ye