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Histatins are a family of multifunctional, cationic histidine-rich saliva peptides. The most prominently represented are Histatin 1, Histatin 3, and Histatin 5. Despite considerable similarities in primary structure, the three members are known to display varied antimicrobial properties and healing abilities. This study aims to provide a detailed structural comparison of Histatin 1, Histatin 3, an

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective

Introduction: Extrauterine pregnancy (EP), represents a significant challenge in reproductive medicine, manifesting in approximately 2% of all pregnancies, primarily implanting within the fallopian tubes (95%). Surgery remains a cornerstone in the therapeutic options for ectopic pregnancies. The most common surgical approach at the moment is laparoscopy. However a relatively new surgical technique

Modern real-time control systems can sporadically exceed the computation deadlines, which may lead to a deterioration in performance or even instability if not actively accounted for. This letter proposes a stochastic model predictive control approach that incorporates deadline miss probabilities of subsequent control task executions in a scenario tree. To account for the effect of missed deadline

This is the Replicated Computational Results (RCR) Report for the article ‘Stress Testing Control Loops in Cyber-Physical Systems’. The article proposes a novel approach for testing Cyber-Physical Systems (CPS) based on the integration of the guarantees that can be provided with the control theoretical models into the software testing practices. This RCR report describes how to reproduce the empir

Dynamic task offloading is essential for real-time robotic applications, enabling them to adapt to fluctuating computational demands and maintain efficiency under changing conditions. This paper introduces a dynamic task offloading framework that incorporates monitoring, decision making, offloading triggering, and performance monitoring to optimize resource usage by offloading real-time tasks to e

The need for information about climate change is great. This information is usually based on climate model data, which often have systematic biases. Furthermore, climate information is based on ensembles of climate models, which raises the question about how such ensembles are affected by the choice of models and emission scenarios. Here, we aim to describe climate change in Sweden and neighbourin

Manual gestures and speech form a single integrated system during nativelanguage comprehension. However, it remains unclear whether this hold forsecond language (L2) comprehension, more specifically for simultaneousinterpreting (SI), which involves comprehension in one language and simultaneousproduction in another. In a combined mismatch and priming paradigm,we presented Swedish speakers fluent i

Efficiently finding covariate model structures that minimize the need for random effects to describe pharmacological data is challenging. The standard approach focuses on identification of relevant covariates, and present methodology lacks tools for automatic identification of covariate model structures. Although neural networks could potentially be used to approximate covariate-parameter relation

The paper presents novel studies on the impact of different ignition control parameters on combustion stability and spark plug wear. First, experimental results from a 32.4-liter biogas fueled large bore single cylinder spark ignition engine are discussed. Two different ignition systems were considered in the experiment: a DC inductive and an AC capacitive. The spark plugs used in the experiment w

We consider distributed consensus in networks where the agents have integrator dynamics of order two or higher (n≥2). We assume all feedback to be localized in the sense that each agent has a bounded number of neighbors and consider a scaling of the network through the addition of agents in a modular manner, i.e., without re-tuning controller gains upon addition. We show that standard consensus al

Background: Cleft lip with cleft palate (CLP) is a congenital condition that affects both the oral cavity and the lips. This study estimated the prevalence and mortality of CLP using surveillance data collected from birth defect registries around the world. Methods: Data from 22 population- and hospital-based surveillance programs affiliated with the International Clearinghouse for Birth Defects S

Shape control strategies seek to bring deformable objects towards a desired target shape. However, conventional methods focus on reaching the target shape without considering the extent to which the object is deformed during the control process. Control actions may generate unnecessary deformations and thus, increase the possibility of object over-stressing and failure. In this letter, we tackle t

Closed-loop motion planning is suitable for obstacle avoidance in dynamically changing environments due to its reactive nature, and various methods have been presented to provide (almost) global convergence. A common assumption in the control design is that the robot operates in a disjoint star world, i.e., all obstacles are strictly starshaped and mutually disjoint. However, in real-life scenario

Epidemics and pandemics are associated with a variety of life-threatening conditions and have serious effects on physical as well as mental wellbeing. The Covid-19 pandemic raised the same difficulties for public and private sectors including schools, businesses, healthcare sectors, etc. The disease, which originated in Wuhan, China in December 2019, has ravaged nearly every country in the world.

Aim: To determine the prevalence of neurobehavioral symptoms at 6.5 years in children born extremely preterm (EPT, <27 weeks' gestation). Methods: Population-based cohort study of infants born EPT in Sweden from 2004 to 2007. Of 486 survivors 375 were assessed and compared with 369 matched term-born controls. EPT children free from neurosensory and intellectual disabilities (neurodevelopmental dis

Control systems are ubiquitous and often at the core of Cyber-Physical Systems, like cars and aeroplanes. They are implemented as embedded software, that interacts in closed loop with the physical world through sensors and actuators. As a consequence, the software cannot just be tested in isolation. To close the loop in a testing environment and root causing failure generated by different parts of