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Between 15 and 27kyrb2k (thousands of years before 2000CE) during the last glacial, Greenland experienced a prolonged cold stadial phase, interrupted by two short-lived warm interstadials. Greenland ice-core calcium data show two periods, preceding the interstadials, of anomalously high atmospheric dust loading, the origin of which is not well understood. At approximately the same time as the Gree

Radiocarbon dating provides a key chronological framework for studying past environmental changes. Raw radiocarbon ages measured in samples must be converted to calendar ages using an appropriate calibration curve. Tree-ring datasets provide the gold-standard for developing a precise curve of atmospheric radiocarbon levels over long-time scales. Here, we reconstruct atmospheric radiocarbon levels

Reliable information on solar activity over the Holocene period is important to predict the Sun in the future and to understand the mechanism behind the Sun-climate linkage. Presently, there are discrepancies in the proxy data of solar activity due to reasons that are not yet understood. This leads to major uncertainties in Holocene solar reconstructions. This PhD project aims to improve the Holoc

In the last two decades, health promotion strategies have gained significant attention in end-of-life care contexts—engendering greater focus on community and informal care in policy and healthcare spheres in liberal welfare-states. The emergence of health-promoting palliative care (HPPC) in the Nordic context presents a unique challenge to the abiding social contract of care which emphasizes the

Extreme solar particle events (ESPEs) are rare and the most potent known processes of solar eruptive activity. During ESPEs, a vast amount of cosmogenic isotopes (CIs) 10Be, 36Cl, and 14C can be produced in the Earth's atmosphere and deposited in natural stratified archives. Accordingly, CI measurements in these archives allow us to evaluate particle fluxes during ESPEs. In this work, we present a

We present an age model for the 651g€¯m deep ice core from Skytrain Ice Rise, situated inland of the Ronne Ice Shelf, Antarctica. The top 2000 years have previously been dated using age markers interpolated through annual layer counting. Below this, we align the Skytrain core to the AICC2012 age model using tie points in the ice and air phase, and we apply the Paleochrono program to obtain the bes

Frequent regression testing is a core activity in agile software development, but large test suites can lead to long test running times, hampering agility. By safe RTS (Regression Test Selection) techniques, a subset of the tests can be identified that cover all tests that can change result since the last run. To pay off in practice, the RTS overhead must be low. Most existing RTS techniques are b

This paper describes the extraction of information on lethal events from the Swedish version of Wikipedia. The information searched includes the persons’ cause of death, origin, and profession. We carried out the extraction using a processing pipeline of available tools for Swedish including a part-of-speech tagger, a dependency parser, and manually-written extraction rules. We also extracted stru

A novel detection algorithm with an efficient VLSI architecture featuring efficient operation over infinite complex lattices is proposed. The proposed design results in the highest throughput, the lowest latency, and the lowest energy compared to the complex-domain VLSI implementations to date. The main innovations are a novel complex-domain means of expanding/visiting the intermediate nodes of th

In this paper, a novel hard-output detection algorithm for the complex multiple-input multiple-output (MIMO) detectors is proposed, which results in a significant throughput enhancement, a near-ML performance, and an SNR-independent fixed-throughput. Moreover, a high-throughput VLSI implementation is proposed, which is based on a novel method of the node generation and sorting scheme. The proposed

Abstract: Long Term Evolution (LTE) supports peak data rates in excess of 300 Mb/s. A good approach to achieve such rates is by parallelizing the required processing in turbo decoders. An interleaver is an important part of a turbo decoder. LTE uses the Quadratic Permutation Polynomial (QPP) interleaver, which makes it suitable for parallel decoding. In this paper, we propose an efficient architec

A novel low-complexity detection scheme is proposed for the multiple-input multiple-output (MIMO) single-carrier frequency division-multiple access (SC-FDMA) systems, which is suitable for ASIC implementations. The proposed detection scheme makes an initial estimate of the transmitted signal based on a minimum mean square error (MMSE) frequency domain equalizer (FDE) detector and finds symbols wit

Ibrutinib, a Bruton’s tyrosine kinase inhibitor is approved for relapsed/refractory and del(17p)/TP53 mutated chronic lymphocytic leukemia. Discrepancies between clinical trials and routine healthcare are commonly observed in oncology. Herein we report real-world results for 95 poor prognosis Swedish patients treated with ibrutinib in a compassionate use program. Ninety-five consecutive patients (

A novel ultra high-throughput detection algorithm with an efficient VLSI architecture for high-order MIMO detectors in the complex constellations is proposed. The main contributions include a new method for the node generation in complex-domain, pipelinable sorters, and a simple combinational circuit instead of the conventional multipliers, which makes the proposed architecture multiplication-free

Closed-loop positivity of feedback interconnections of positive monotone nonlinear systems is investigated. It is shown that an instantaneous gain condition on the open-loop systems which implies feedback well-posedness also guarantees feedback positivity. Furthermore, the notion of integral linear constraints (ILC) is utilised as a tool to characterise uncertainty in positive feedback systems. Ro

In this paper, we present two distributed algorithms to compute an equilibrium, that is optimal with respect to strictly convex and separable cost functions, for controlled traffic flow dynamics over networks under constant exogenous inflows. The dynamics is modeled in continuous time by the Cell Transmission Model and a non-FIFO Dynamic Network Loading Model, with traffic control. The two algorit

Molecular titration is emerging as an important biochemical interaction mechanism within synthetic devices built with nucleic acids and the CRISPR/Cas system. We show that molecular titration in the context of feedback circuits is a suitable mechanism to enhance the emergence of oscillations and bistable behaviors. We consider biomolecular modules that can be inhibited or activated by input monome

The paper presents and analyses some nonlinear continuous-time dynamic models of social systems whose members, groups or individuals, may change partners and/or opponents at any time, according to a greedy criterion. The main structural properties of these models, which belong to the class of positive switching systems, are investigated with particular regard to the existence of solutions, their p

We consider the problem of identifying structural influences of external inputs on steady-state outputs in a biological network model. We speak of a structural influence if, upon a perturbation due to a constant input, the ensuing variation of the steady-state output value has the same sign as the input (positive influence), the opposite sign (negative influence), or is zero (perfect adaptation),