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Background: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohist

A calibration model was developed for a non-invasive blood glucose sensor, to determine how the blood glucose data measured by this sensor is related to blood glucose data measured with laboratory capillary finger sticks and to corrupting noise. The variability of calibration models for different patients was analyzed as well as the dynamics of the non-invasive blood glucose sensor according to re

We investigated a 3.75-m-long lacustrine sediment record from Lake Äntu Sinijärv, northern Estonia, which has a modeled basal age >12,800 cal yr BP. Our multi-proxy approach focused on the stable oxygen isotope composition (δ18O) of freshwater tufa. Our new palaeoclimate information for the Eastern Baltic region, based on high-resolution δ18O data (219 samples), is supported by pollen and plant ma

OBJECTIVE: To determine what constitutes normal cervical changes during the second half of pregnancy in parous women delivering at term. DESIGN: The study comprises 21 healthy, pregnant parous women who all gave birth at term. They were examined with transvaginal ultrasound every two weeks from 24 gestational weeks until delivery. Cervical length and width were measured. The inner cervical os was

The study is based on monitoring data on the seasonal variation during four (1996-1999) vegetation periods, as well as long-term summer data on submerged vegetation, nutrients, light, phyto-plankton and zooplankton in Lake Krankesjon, a shallow, calcium-rich, moderately eutrophic take in southern Sweden. The lake has been in the clear water state with abundant submerged vegetation since the end of

This contribution presents a novel offline dynamic multi-objective optimization framework for high-pressure liquid chromatographic (HPLC) processes in batch elution mode. The framework allows for optimization of general elution trajectories parametrized with piecewise constant control signals. It is based on a simultaneous method where both the control and state variables are fully discretized in

Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. In study I, we demonstrated that 20% of the patients in a population-based series of 818 STS developed second primary malignancies. An increased risk of

The overall aims of this thesis were to investigate the prevalence, severity and bother of Lower Urinary Tract Symptoms (LUTS) in a clinical sample of stroke patients and to evaluate the effect of pelvic floor muscle training (PFMT) in women with urinary incontinence after ischemic stroke. The thesis consisted of 6 articles based on 4 studies and a review. In the first study (Paper I), the Danish

A consecutive series of patients with all types of cervical hip fracture (both undisplaced and displaced) were randomised to osteosynthesis with Hansson hook-pins (n = 98) or AO-screws (n = 101). Background parameters, fracture type and reduction of the fracture did not differ significantly between the groups. Fifty-seven percent of the patients were operated on within 6 h of admission to hospital

In a prospective study of a consecutive breast cancer series accumulated in the period 1978-82, the S-phase fraction (SPF) and ploidy status were determined by flow cytometry performed on cell nuclei derived from samples of 580 primary tumors. Sixty percent of the tumors were non-diploid. After correction for debris the median SPF values were 7.3% overall, 12% for non-diploid tumors, and 2.9% for

Background: The maintenance of postural control is fundamental for different types of physical activity. This can be measured by having subjects stand on one leg on a force plate. Many studies assessing standing balance have previously been carried out in patients with ankle ligament injuries but not in patients with ankle fractures. The aim of this study was to evaluate whether patients operated

Objective. Increasing survival of extremely low birth weight (ELBW; birth weight < 1000 g) infants raises a concern regarding the risks of adverse long-term outcome such as cognitive dysfunction. Few studies have reported long-term follow-up of representative regional cohorts. The objective of this study was to assess the 5-year outcome of a prospectively followed national ELBW infant cohort. Meth

Patients with acute asthma attending the emergency room were included in a double-blind, double-dummy and parallel group study to investigate whether a dry powder inhaler (Turbuhaler) can be used in acute asthma. If so, the aim was to establish the potency relationship between a beta 2-agonist (salbutamol) administered by the dry powder inhaler and the pressurized metered-dose inhaler (pMDI). Eigh

Popular Abstract in Swedish Arktis utgör en viktig del i Jordens miljö och vad som händer där har stor påverkan på det globala klimatet, samtidigt som området är mycket känsligt för förändringar. Under kvartärtiden har stora isar flera gånger täckt Skandinavien, Ryssland, Sibirien och Nordamerika och täcker än idag stora delar av Grönland. Isarna har lämnat spår (landformer och sediment) efter sigThe North Taymyr ice-marginal zone (NTZ) on the Taymyr Peninsula, Arctic Siberia and the Ugleelv Valley on Jameson Land, East Greenland, have been investigated with the aim of reconstructing the glacial history, including depositional processes and environments. Geomorphological, sedimentological, stratigraphical and remote sensing methods have been combined to give a comprehensive view of develop

Context: Secondary hypogonadism is common in aging men; its natural history and predisposing factors are unclear. Objectives: The objectives were 1) to identify factors that predispose eugonadal men (T >= 10.5 nmol/L) to develop biochemical secondary hypogonadism (T < 10.5 nmol/L; LH <= 9.4 U/L) and secondary hypogonadal men to recover to eugonadism; and 2) to characterize clinical features associ

Governmental organisations are becoming more critically dependant on IT systems such as communication systems or patient data systems, both for their everyday tasks and their role in crisis relief activities. Therefore it is important for the organisation to analyse the reliability of these systems as part of the organisation’s risk and vulnerability analysis process. This paper presents a practic

An aim of the present paper is to examine changes in the magnitude and direction of time-order effects with changes in the physical magnitude of the stimuli, overall levels of performance, and with changes in load processing capacity. Increments and decrements in performance are gauged by means of the steepness of psychometric and chronometric functions. Load processing capacity is assessed by div

Bytecode folding is an effective technique for speeding up execution in Java virtual machines. This paper investigates a hardware implementation of the aforementioned technique on BlueJEP, a Java embedded processor. Since BlueJEP is a micro-programmed stack machine, we adopt a micro-instruction oriented approach, folding up to four microinstructions (corresponding to up to four bytecodes, on occas

Abstract in UndeterminedFor assembly tasks, the knowledge of both trajectory and forces are usually required. Consequently, we may use kinesthetics or teleoperation for recording human demonstrations. In order to have a more natural interaction, the operator has to be provided with a sense of touch. We propose a bilateral teleoperation system which is customized for this purpose. We introduce diff

We are concerned with software that can self-adapt to satisfy certain reliability requirements, in spite of adverse changes affecting the environment in which it is embedded. Self-adapting software architectures are heavily based on dynamic binding. The bindings among components are dynamically set as the conditions that require a self-adaptation are discovered during the system's lifetime. By ado