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Pediatric obsessive-compulsive disorder (OCD) clusters around three major symptom dimensions: contamination/cleaning, symmetry/ordering, and disturbing thoughts/checking. The Obsessive-Compulsive Inventory-Child Version (OCI-CV) is a self-report questionnaire that provides scores along six theory-based OCD dimensions, but no study has evaluated how well OCI-CV identifies clinically significant sym
The clinical commissioning of beams for neutron capture therapy involves the measurement and analysis of a large amount of data in various geometries and using various detectors. We have attempted methods and considerations common to the radiotherapy field, while particular care and attention is given to the specifics of the field of neutron capture therapy. This chapter provides an introduction a
BACKGROUND: The tau-PET radiotracer [18F]flortaucipir enables in vivo detection of tau pathology in Alzheimer's Disease (AD) and has recently been FDA- and EMA-approved for clinical use. To support its implementation, we assessed tau-PET's positive predictive value (PPV) and negative predictive value (NPV) for clinico-pathological AD while accounting for age, amyloid-status, and pre-PET diagnostic
Background: Normal hand function relies on a finely tuned interaction between the sensory and motor systems within the central and peripheral nervous systems. The central nervous system continuously adapts to changed activity, environmental changes, learning, and injury — a phenomenon known as neuroplasticity. The neuroplasticity is a life-long ability and presents opportunities for therapeutic in
The T-REX neutron spectrometer at the European Spallation Source will use Multi-Grid Technology, which is a voxelised proportional counter relying on 10B4C coatings to detect neutrons scattered by the sample under investigation. Measurements of the position dependence of pulse-height and relative detection efficiency of a Multi-Grid prototype of the T-REX spectrometer are presented for two differe
Shared ground heat exchange can deliver low-carbon electrified heat where individual heat pumps or heat networks are not feasible, such as in terraced homes. However, there is a policy gap around these mid-scale heat solutions. We outline the benefits and challenges of shared ground heat exchange, and actions needed by policy, housing, and innovation stakeholders to support further deployment.
This paper examines income and employment outcomes for immigrants in Sweden’smost immigrant-dense neighbourhoods between 1998 and 2022. While relativeemployment among immigrants has improved, relative incomes in theseneighbourhoods have stagnated or declined. The most plausible explanation for thepersisting income gap and the shrinking employment gap between immigrant-dense and other neighbourhood
The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered regulatory segment whose conserved YENPTY motif mediates transient interactions with multiple adaptor and signaling proteins. How sequence perturbations within this motif modulate its accessibility and interaction potential within a disordered ensemble remains poorly understood. Here, we combine small-angle X-
Money is central to capitalism and its sustainability crises. This article argues that it is not money itself, but its internal design and governance – how it is created, distributed, and governed – that drives inequality, ecological degradation, and unsustainable growth. Yet, money’s architecture is not fixed; it can be reimagined to foster fairer, greener economies.Approaching money as a socio-t
Spiral spin liquids are an exotic class of correlated paramagnets with an enigmatic magnetic ground state composed of a degenerate manifold of fluctuating spin spirals. Experimental realizations of the spiral spin liquid are scarce, mainly due to the prominence of structural distortions in candidate materials that can trigger order-by-disorder transitions to more conventionally ordered magnetic gr
Combined quantum mechanics and molecular mechanics (QM/MM) calculations are a popular approach to study reaction mechanisms of enzymes. However, recently, the reproducibility of such calculations has been questioned, comparing the results of two software: NWChem and Q-Chem. Here, we continue and extend this study by including three additional software─ComQum, ORCA, and AMBER─using the same test ca
Despite the advancement in background rejection techniques, observation of the very-high-energy gamma-ray sky by imaging atmospheric Cherenkov telescopes (IACTs) are subject to an irreducible background from gamma-like hadron- or electron-induced air showers. The determination of this residual background is crucial for accurate spectral and spatial measurements. The Cherenkov Telescope Array (CTA)
ObjectivesThe objective was to develop an artificial intelligence (AI) model for predicting acute coronary occlusion myocardial infarction (OMI) in patients with chest pain at the emergency department (ED), using information that is widely available early in the ED assessment.MethodsIn a cohort of 24,511 consecutive adult ED patients with chest pain from 5 Swedish hospitals, OMI cases were identif
The increase in the scale of LHC computing during Run 3 and Run 4 (HL-LHC) will certainly require radical changes to the computing models and the data processing of the LHC experiments. The working group established by WLCG and the HEP Software Foundation to investigate all aspects of the cost of computing and how to optimise them has continued producing results and improving our understanding of
To be able to exploit the anticipated interaction rate of 50 kHz in Pb-Pb collisions during run 3 of the LHC (beyond 2019), the ALICE TPC will be upgraded to allow continuous readout. As this is not possible with the current Multi Wire Proportional Chamber (MWPC) based amplification, the readout will be replaced with Gas Electron Multiplier (GEM) readout chambers that can suppress ~ 99% of the ion
At the Fifth International Workshop on Peritoneal Surface Malignancy, held in Milan, the consensus on technical aspects of cytoreductive surgery (CRS) for peritoneal surface malignancy was obtained through the Delphi process. General conflicting points concerning the eligibility to the local-regional therapy were discussed and voted.
Coronavirus disease 2019 (COVID-19) has caused global disruption and a significant loss of life. Existing treatments that can be repurposed as prophylactic and therapeutic agents may reduce the pandemic’s devastation. Emerging evidence of potential applications in other therapeutic contexts has led to the investigation of dietary supplements and nutraceuticals for COVID-19. Such products include v
