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Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E
Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m
OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>
Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly
In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of
Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured
Varje år orsakar luftföroreningar 7 miljoner dödsfall globalt. Klimatet både värms och kyls av luftföroreningar, vilket gör dem till en av de största osäkerhetsfaktorerna i klimatmodeller. Den gröna omställningen och vår strävan efter cirkulär ekonomi kommer innebära att några luftföroreningskällor försvinner, men också att nya kommer att introduceras. Dessa komplexa problem behöver angripas transEvery year, 7 million people die due to exposure to air pollution. Air pollution both heats and cools global temperatures, hence it is one of the major reasons for uncertainties in climate models. The green transition and our aim for a circular economy will remove some of our current air pollution sources but introduce new ones. These complex questions demand a transdisciplinary approach. This cou
Denna kurs introducerar lingvistikstudenten i forskningsmetodik och metodologiska frågor, och förbereder för uppsatsarbete på fördjupningsnivå. Kursen behandlar metodologiska frågor såsom att formulera frågeställningar, skillnaden mellan kvantitativa och kvalitativa metoder, induktiva och deduktiva metoder, och forskningsetiska frågor. Under kursen får du praktisk träning i några vanliga lingvistiThis course introduces the linguistic student to research methods and methodological issues, and prepares the student for writing an essay on B.A. level. The course includes methodological issues such as formulating research questions, the difference between quantitative and qualitative methods, inductive and deductive methods, and ethical questions. During the course, you will practice some commo
Vill du fördjupa din förståelse för de två vanligaste neurodegenerativa sjukdomarna? Den här kursen ger dig fördjupade kunskaper om Alzheimers och Parkinsons sjukdom – från sjukdomsmekanismer till diagnostik, konsekvenser och behandling. Du lär dig om moderna metoder som hjärnavbildning, biomarkörer och digitala tester, sjukdomens konsekvenser, och olika behandlingsalternativ (farmakologi, kirurgiDo you want to deepen your understanding of the two most common neurodegenerative diseases? This course provides you with in-depth knowledge of Alzheimer's and Parkinson's disease – from disease mechanisms to diagnostics, consequences, and treatments. You will learn about modern methods such as brain imaging, biomarkers and digital tests, consequences in everyday life, and different treatmen
The course will introduce and elaborate on various theoretical perspectives of war and peace in the Israeli-Palestinian conflict. Central issues to be discussed and compared over time are (1) the causes of the conflict, such as identity, nationalism, religion, territory and great power politics; (2) the Middle Peace Process (MEPP), which highlights the various agreements, peacebuilding by third paThe course will introduce and elaborate on various theoretical perspectives of war and peace in the Israeli-Palestinian conflict. Central issues to be discussed and compared over time are (1) the causes of the conflict, such as identity, nationalism, religion, territory and great power politics; (2) the Middle Peace Process (MEPP), which highlights the various agreements, peacebuilding by third pa
Kursen behandlar: Direkta och iterativa lösningsmetoder för olika problem i lineär algebra, såsom lineära ekvationssystem, egenvärdesproblem och minsta-kvadratmetoden, Matris- och vektornormer, ortogonalisering, projektion, matrisfaktoriseringar, direkta och iterativa lösare, konditionstal, stabilitet hos en metod, komplexitet hos en algoritm, Tillämpning av ovanstående begrepp för att konThe course covers: Direct and/or iterative solution methods for various linear algebra problems such as linear systems of equations, eigenvalue problems and the least-squares method, Matrix and vector norms, orthogonalisation, projection, matrix factorisations, direct and iterative solvers, condition numbers, stability of a method, complexity of an algorithm, Applying these con
I denna kurs kommer du att utforska teoretiska och praktiska koncept avseende hållbar turism samt hur planering kan utföras i ett GIS. Du lär dig också praktiska och teoretiska övningar i hur ett känsligt naturområde kan kategoriseras i känslighet för turism, samt hur GIS kan användas för fältmätningar av turistpåverkan, samt för analys och visualisering. Dessutom undersöker vi hur ett förenklat bIn this course you will explore theoretical and practical concepts of sustainable tourism planning and how tourism can be planned using a GIS. Furthermore a simplified Tourism Decision Support System (TDSS) will be explored and how such a system can be linked to a GIS. This course includes practical and theoretical exercises regarding categorisation of sensitivity for land exposed to tourism and h
The course explores and explains the historical processes of rapid industrialisation and socio-economic modernisation in Pacific Asia. First, fundamental factors and forces behind the rise of Asia’s first industrial nation, Japan, are analysed. Japan is also contrasted against the early failures of modernisation in Imperial China. Secondly, explanations are provided for the emergence of Taiwan,
I kursen studeras kommunismens utveckling efter andra världskriget, med särskild inriktning på situationen i Öst- och Centraleuropa. Syftet är att studera kommunismens utveckling under det kalla kriget från konferensen i Jalta år 1945 till Sovjetunionens sammanbrott år 1991 och dess följder under 1990- och 2000- talet. Perspektiven som anläggs är både genetiska och genealogiska.The course addresses the development of communism after World War II, focusing on the situation in Central and Eastern Europe. The aim is to study the development of communism during the Cold War, from the Yalta conference in 1945 to the fall of the Soviet Union in 1991, and its consequences in the 1990s and early twenty-first century. The subject is addressed from both genetic and genealogical pe
