Search results

Cancer immunotherapies activate the immune system to overcome tumor resistance and restore the antitumor immune response, however, excessive activation of the immune system may also affect normal tissues and organs and cause immune-related adverse events (irAEs) of varying severity. Current in vitro assays used for testing and predicting of irAEs induced by immunotherapeutics are associated with s

This paper aims to analyze the influential factors by parallel analysis of both regions (Yangtze and Oresund) and then explore the possible model for Yangtze ICT cluster based on the experience of Oresund ICT. Through the qualitative and quantitative analysis, we find the result that there is no universal model of cluster that can be applied to any region directly. The model of Chinese ICT cluster

This report is a result of a Master Thesis made at Volvo 3P and the Department of Advance Engineering and Concepts. The thesis is a part of the education in Mechanical Engineering at the Department Design Sciences, for the Division of Machine Design at Lund University. Volvo 3P is involved in a project regarding a new patented manufacturing method that is under development. The manufacturing metho

This thesis is based on an eight week long field-study in Dar es Salaam, Tanzania, with the aim of examining the challenges and opportunities for women’s empowerment through taking a micro-credit loan within a Non Governmental Organization (NGO) named Village Community Bank (VICOBA). This is done because of the posed objective that micro-credit lending to women is a tool for empowering them, there

Due to various reasons like globalization and conflicts many countries are experiencing high levels of in-and outmigration. Strongly increased diversified migration has evoked a multiple reactions from the receiving societies. On the one hand, civil societies may respond positively and openly towards immigrants, but on the other hand, there have been significant changes in public and political att

Human Rights Accountability är en egenskap i relationen mellan styrande och medborgare. När egenskapen existerar förhindrar den människorättskränkningar genom att medborgarna får inflytande över beslutfattande. Begreppet behöver klargöras för att nå sitt fulla potential som verktyg för planering och analys eftersom missförståelse kan ha farliga konsekvenser i misslyckandet att förebygga politiskt Human Rights Accountability is a property of the relationship between rulers and citi-zens. When it exists, it prevents violations of Human Rights by enabling citizens to in-fluence decision-making. The concept needs clarification in order to reach its full poten-tial as a tool for planning and analysis. Misunderstanding can have dangerous conse-quences in the failure to prevent political violence

The Troubles in Northern Ireland have played a prominent part in modern European history. Despite the success of the Peace Process in the 1990s and subsequent stabilisation of the conflict through the introduction of power-sharing and paramilitary decommissioning of weapons, tensions still dominate the province. This thesis uses the Copenhagen School of Security Studies to investigate processes of

Increases in global mean temperatures have caused the climate to change, affecting the frequency and magnitude of extreme events. Series of daily minimum temperatures for the period 1951-2014 has been analyzed in Sweden. It was found that cold extremes such as frost days, cold spells and annual minimum temperatures all show significant warming trends with a statistical significance of 90%. Frost d

In recent years, land acquisition has escalated due to increased global demand for food and fuel driven by population growth, urbanisation, and growing energy demand. Mozambique is ranked as one of the world’s top 10 countries with available land for agriculture, forestry and livestock production. Low labour costs and land taxes may further increase the interest in Mozambican land. In particular,

The building sector is one that can be accounted for numerous impacts on the environment, both by extremely high consumption of resources, and by emitting green house gases to the atmosphere on a large scale. Retrofitting existing buildings tackles energetic and emission related issues and one way to go about such projects is through the process of high-performance building certification, within w

In recent years, the Arctic has been one of the most dynamic environments on Earth. As a result, scientific inquiry into the region has produced a large amount of data, with future projections of the volume of data for the Arctic as well as the Antarctic expected to increase by an order of magnitude. On the receiving end of these data, a challenge remains as how to best manage, archive and distrib

Abstract The current Standard Model cannot explain many properties of the neutrino, including its mass. Models exist where a postulated heavy Majorana neutrino will give rise to the observed small neutrino mass currently observed. This thesis presents a search for indications of Majorana neutrinos with focus on finding heavy neutrinos and W_R-bosons predicted by the Left-Right Symmetric Model. Pro

Objectives: We evaluated a method for gas monitoring in the mastoid cavity using tunable diode laser spectroscopy by comparing it to simultaneously obtained computed tomographic (CT) scans. Methods: The presented optical technique measures free gases, oxygen (O2), and water vapor (H2O) within human tissue by use of low-power diode lasers. Laser light was sent into the tip of the mastoid process

Recent urban microclimate studies in Colombo, Sri Lanka, indicate that the maximum daily temperature within street canyons decreases with increasing height to width (H/W) ratio, but higher H/W ratio negatively affects street-level wind flow. There is also evidence pointing to the cooling effect of sea breeze. The nocturnal heat island is small in contrast to daytime urban-rural differences. In thi

The vitamin K-dependent anticoagulant protein S binds with high affinity to C4b-binding protein (C4BP), a regulator of complement. Despite the physiological importance of the complex, we have only a patchy view of the C4BP-binding site in protein S. Based on phage display experiments, protein S residues 447-460 were suggested to form part of the binding site. Several experimental approaches were n

We compute Poisson kernels for integer weight parameter standard weighted biharmonic operators in the unit disc with Dirichlet boundary conditions. The computations performed extend the supply of explicit examples of such kernels and suggest similar formulas for these Poisson kernels to hold true in more generality. Computations have been carried out using the open source computer algebra package

Purpose: To present an evaluation method for three-dimensional Look-Locker (3D-LL) based T1 quantification, calculating correct T1 values independent of local flip angle (FA) variations. The method was evaluated both in phantoms and in vivo in a delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) study with 33 subjects. Materials and Methods: T1 was measured with 3D-LL, using both local FA corr

The emerging field of proteomics has created a need for new high-throughput methodologies for the analysis of gene products. An attractive approach is to develop systems that allow for clonal selection of interacting protein pairs from large molecular libraries. In this study, we have characterized a novel approach for identification and selection of protein-protein interactions, denoted SPIRE (se