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The Italian Sarcoma Group and the Scandinavian Sarcoma Group designed a joint study to improve the prognosis for patients with Ewing's family tumors and synchronous metastatic disease limited to the lungs, or the pleura, or a single bone. The study was opened in 1999 and closed to the enrollment in 2008. The program consisted of intensive five-drug combination chemotherapy, surgery and/or radiothe
Laurdan (6-lauroyl-2-dimethylaminonaphthalene) fluorescence spectroscopy has been applied to probe the physical status of the thylakoid membrane upon conversion of violaxanthin to zeaxanthin. So far, only phospholipid-dominated membranes have been studied by this method and hereby we report the first use of laurdan in mono- and digalactosyldiacylglycerol-dominated membrane systems. The generalised
Community-acquired infections, including respiratory tract infections (RTIs) and urinary tract infections (UTIs), represent a major burden for most healthcare systems, partially due to ineffective or inappropriate antibiotic treatment leading to clinical failure, which often requires alternative antibiotics for cure. Appropriate antimicrobial use not only maximises clinical success in the treatmen
We consider a moving-boundary problem associated with the fluid model for biofilm growth proposed by J. Dockery and I. Klapper, Finger formation in biofilm layers, SIAM J. Appl. Math. 62 (3) (2001) 853–869. Notions of classical, weak, and variational solutions for this problem are introduced. Classical solutions with radial symmetry are constructed, and estimates for their growth given. Using a we
The paper provides an exploratory empirical survey of Application Service Providers (ASPs) and their clients. The research question is: what do Small and Medium-sized Enterprises (SMEs) base their decision on when adopting the ASP concept? The concept, ASP, consists of software vendors, and an ASP enterprise, which act as a third part firm in a business model. For its clients it forms a strategy t
Common practice in industry is to rotate the milling cutter in only one direction even though the geometry of the inserts are thus that they could be used again while the milling cutter is rotating in the opposite direction. The aim of this study was to investigate to what extent it is possible to increase the tool utilization during milling by first rotating the milling cutter in one direction un
Massive MIMO has been shown to greatly improve spectral and transmit-energy efficiency. When implementing a massive MIMO system, one challenge is high hardware complexity. A solution is to reduce the number of radio frequency (RF) transceiver chains by performing antenna selection. However, a full RF switch that connects the antennas and RF chains can be highly complex and incurs significant loss
Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. Antiproliferative spermine-binding DS fragments (tetra- to decasaccharides), and aff
Abstract is not available
Combining the strengths of an advanced mathematical model of human physiology and a thermal manikin is a new paradigm for simulating thermal behaviour of humans. However, the forerunners of such adaptive manikins showed some substantial limitations. This project aimed to determine the opportunities and constraints of the existing thermal manikins when dynamically controlled by a mathematical model
Biological diversity encompasses the genetic diversity within each species, the range of species in a given ecosystem e.g. species diversity and the diversity of ecosystems across an entire region (Primack, 2000). At present 1 per cent of the world’s described species are threatened with extinction. The most pervasive and overriding threat is habitat loss and degradation due to human activity such
What kind of indispensable cognitive ability is needed for intelligence, sociability, communication, and technology to emerge on a habitable planet? My answer is simple: intersubjectivity. I stress the significance of intersubjectivity, of shared cognition, for extraterrestrial intelligence and interstellar communication, and argue that it is in fact crucial and indispensable for any successful in
This thesis is divided into two parts in which two different aspects of the Large Hadron Collider (LHC) Project are discussed. The first part describes the design of a transition radiation tracker (TRT) for the inner detector in ATLAS. In particular, the barrel part was studied in detail. The barrel TRT consists of 52 544 1.5-m-long proportional tubes (straws), parallel to the beam axis and each
Proton exchange membrane fuel cell (PEMFC) systems have been investigated as alternative power sources for the stationary and automotive applications. However, they do not appear on the market yet. One of the main reasons is the difficulty of the water/thermal management in the system. Several water recovery schemes have been proposed to overcome this difficulty and to simplify the system configur
A solvent-free microextraction technique based on liquid-gas-liquid microextraction was investigated for the extraction and preconcentration of 2,4-di-tert-butyl phenol from aqueous samples. In this study 16 mu L NaOH 1 M as acceptor phase was introduced in the lumen of a polypropylene hollow fiber, with one of its ends heat-sealed. A small piece (about 2 cm) of metallic wire was used to seal the
