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Importance: The behavioral variant of Alzheimer disease (bvAD) is characterized by early and predominant behavioral deficits caused by AD pathology. This AD phenotype is insufficiently understood and lacks standardized clinical criteria, limiting reliability and reproducibility of diagnosis and scientific reporting. Objective: To perform a systematic review and meta-analysis of the bvAD literature
Identifiability and sensitivity of thermal boundary coefficients identified alongside thermal material parameters by means of full field measurements during a simple tension test are shown empirically using a simple tension test with self heating as a proof of concept. The identification is started for 10 different initial guesses, all of which converge toward the same optimum. The solution appear
Legislative efforts for renewables-based energy decarbonisation hinge upon the support and commitment from different stakeholders holding often conflicting positions regarding disruptive processes of socio-technical transformation. However, the evolving acceptance of market actors on the policy-driven promotion of renewables over time remains under-scrutinised. Simultaneously, despite growing atte
β-Mannan is abundant in the human diet and in hemicellulose derived from softwood. Linear or galactose-substituted β-mannan-oligosaccharides (MOS/GMOSs) derived from β-mannan are considered emerging prebiotics that could stimulate health-associated gut microbiota. However, the underlying mechanisms are not yet resolved. Therefore, this study investigated the cross-feeding and metabolic interaction
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms, including pain, discomfort, and success rate, of any pharmacological intervention during lumbar puncture in newborn infants, compared to placebo, no intervention, non-pharmacological interventions, or other pharmacological interventions.
The capabilities of current computer simulations provide a unique opportunity to model small-angle scattering (SAS) data at the atomistic level, and to include other structural constraints ranging from molecular and atomistic energetics to crystallography, electron microscopy and NMR. This extends the capabilities of solution scattering and provides deeper insights into the physics and chemistry o
The financing of energy efficiency measures and renovations is key to reaching energy efficiency targets for the housing sector. The purpose of this article is to add the Swedish case of how capital market funds have become accessible and used by public and private housing companies, in particular for energy efficiency measures. The core of this article are interviews with representatives of Swedi
Minimizing the fiber property distribution would have the potential to improve the pulp properties and the process efficiency of chemimechanical pulp. To achieve this, it is essential to improve the level of knowledge of how evenly distributed the sulfonate concentration is between the individual chemimechanical pulp fibers. Due to the variation in quality between pulpwood and sawmill chips, as we
In this paper, we focus on the design of the transmit waveforms of a frequency diverse array (FDA) in order to improve the output signal-to-interference-plus-noise ratio (SINR) in the presence of signal-dependent mainlobe interference. Since the classical multi-carrier matched filtering-based FDA receiver cannot effectively utilize the waveform diversity of FDA, a novel FDA receiver framework base
Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cell
During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv
AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b
In this paper we show that OpenAI’s Large Language Model (LLM) GPT perform remarkably well when used for title and abstract eligibility screening of scientific articles and within a (systematic) literature review workflow. We evaluated GPT on screening data from a systematic review study on electric vehicle charging infrastructure demand with almost 12,000 records using the same eligibility criter
Global policies, legislation, and eco-friendly initiatives have induced the steel industry to integrate sustainable development approaches. Sustainability requires all phases from raw material sourcing to transportation to waste and carbon footprint elimination—yielding positive effects. This research employs a two-step approach in sustainability. The first phase entails conducting a systematic li
The delay between the origin of animals in the Neoproterozoic and their Cambrian diversification remains perplexing. Animal diversification mirrors an expansion in marine shelf area under a greenhouse climate, though the extent to which these environmental conditions directly influenced physiology and early organismal ecology remains unclear. Here, we use a biogeochemical model to quantify oxygen
Key questions for understanding hippocampal function in memory and navigation in humans are the type and source of visual information that reaches the human hippocampus. We measured bidirectional pairwise effective connectivity with functional magnetic resonance imaging between 360 cortical regions while 956 Human Connectome Project participants viewed scenes, faces, tools, or body parts. We devel
INTRODUCTION: We evaluated differences in p-tau levels between Alzheimer's disease (AD), a condition with brain-specific changes in p-tau, and amyotrophic lateral sclerosis (ALS), a condition associated with increases in peripheral p-tau levels. METHODS: Cerebrospinal fluid and plasma from 668 participants were analyzed using immunoassays specific for the low-molecular-weight (LMW) tau isoforms pr
Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal
How we teach is strongly influenced by the culture we teach in, especially what (we believe) our colleagues think is good and acceptable. Understanding the reluctance to changes in teaching practice, including fear of disapproval from colleagues and students, investigating and reappraising those fears, and starting to talk about alternative interpretations is a first step towards overcoming the in
Precise knowledge of the temperature during cutting processes is of high interest as the temperature of a cutting tool dictates the performance, and for the workpiece it controls the quality and integrity of the generated surface. For the first time, in this study, a novel technique has been developed utilizing phosphor thermometry for 2D surface temperature measurement of a cutting tool in metal
