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To assess the role of CHCHD2 variants in patients with Parkinson disease (PD) and Lewy body disease (LBD) in Caucasian populations.

Popular Abstract in Swedish Tillväxtfaktorer påverkar signaler mellan celler i hjärnan Människors hjärnor innehåller flera miljarder hjärnceller, vilka är förutsättningen för vårt beteende, våra känslor och våra tankar. Hjärncellerna bildar kontakter, synapser, med varandra. Genom dessa överförs signaler från en cell till en annan. Varje cell kontaktar en mängd andra celler, både sådana med liknanThe neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. Such plasticity is believed to be a cellular correlate for important processes like learning, but also for diseases, for

BACKGROUND: Maternally derived duplications of the 15q11-q13 region are the most frequently reported chromosomal aberrations in autism spectrum disorders (ASD).Prader-Willi and Angelman syndromes, caused by 15q11-q13 deletions or abnormal methylation of imprinted genes, are also associated with ASD. However, the prevalence of these disorders in ASD is unknown. The aim of this study was to assess t

Computers are increasingly used for implementing controlalgorithms in safety-critical embedded applications, such asengine control, braking control and flight surfacecontrol. Addressing the consequent coupling of control performancewith computer related errors, this paper develops a composite computerdependability/control theory methodology for analyzing the effectsdata errors have on control syst

This report is a result of a Master Thesis made at Volvo 3P and the Department of Advance Engineering and Concepts. The thesis is a part of the education in Mechanical Engineering at the Department Design Sciences, for the Division of Machine Design at Lund University. Volvo 3P is involved in a project regarding a new patented manufacturing method that is under development. The manufacturing metho

This master thesis is commissioned by the company Haldex Brake Products AB based in Landskrona. The company is acting on the road vehicle market. Amongst other products the company produces disc brakes for the heavy road vehicle industry. Disc brakes developed by Haldex, based on the sliding caliper principle, are during certain circumstances experiencing problems with malfunction of the brake due

This thesis is based on an eight week long field-study in Dar es Salaam, Tanzania, with the aim of examining the challenges and opportunities for women’s empowerment through taking a micro-credit loan within a Non Governmental Organization (NGO) named Village Community Bank (VICOBA). This is done because of the posed objective that micro-credit lending to women is a tool for empowering them, there

Due to various reasons like globalization and conflicts many countries are experiencing high levels of in-and outmigration. Strongly increased diversified migration has evoked a multiple reactions from the receiving societies. On the one hand, civil societies may respond positively and openly towards immigrants, but on the other hand, there have been significant changes in public and political att

Human Rights Accountability är en egenskap i relationen mellan styrande och medborgare. När egenskapen existerar förhindrar den människorättskränkningar genom att medborgarna får inflytande över beslutfattande. Begreppet behöver klargöras för att nå sitt fulla potential som verktyg för planering och analys eftersom missförståelse kan ha farliga konsekvenser i misslyckandet att förebygga politiskt Human Rights Accountability is a property of the relationship between rulers and citi-zens. When it exists, it prevents violations of Human Rights by enabling citizens to in-fluence decision-making. The concept needs clarification in order to reach its full poten-tial as a tool for planning and analysis. Misunderstanding can have dangerous conse-quences in the failure to prevent political violence

The Troubles in Northern Ireland have played a prominent part in modern European history. Despite the success of the Peace Process in the 1990s and subsequent stabilisation of the conflict through the introduction of power-sharing and paramilitary decommissioning of weapons, tensions still dominate the province. This thesis uses the Copenhagen School of Security Studies to investigate processes of

Increases in global mean temperatures have caused the climate to change, affecting the frequency and magnitude of extreme events. Series of daily minimum temperatures for the period 1951-2014 has been analyzed in Sweden. It was found that cold extremes such as frost days, cold spells and annual minimum temperatures all show significant warming trends with a statistical significance of 90%. Frost d

In recent years, land acquisition has escalated due to increased global demand for food and fuel driven by population growth, urbanisation, and growing energy demand. Mozambique is ranked as one of the world’s top 10 countries with available land for agriculture, forestry and livestock production. Low labour costs and land taxes may further increase the interest in Mozambican land. In particular,

The building sector is one that can be accounted for numerous impacts on the environment, both by extremely high consumption of resources, and by emitting green house gases to the atmosphere on a large scale. Retrofitting existing buildings tackles energetic and emission related issues and one way to go about such projects is through the process of high-performance building certification, within w

In recent years, the Arctic has been one of the most dynamic environments on Earth. As a result, scientific inquiry into the region has produced a large amount of data, with future projections of the volume of data for the Arctic as well as the Antarctic expected to increase by an order of magnitude. On the receiving end of these data, a challenge remains as how to best manage, archive and distrib