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By use of a batch microcalorimeter of the thermopile type, heat production was measured in isolated populations of human peripheral blood cells exposed to defined immune complexes formed in vitro. It was found that most of the heat production recorded in whole blood after admixture of immune complexes occurs in the granulocytes. Under these conditions small but constantly higher activation values

Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Kursen behandlar: Direkta och iterativa lösningsmetoder för olika problem i lineär algebra, såsom lineära ekvationssystem, egenvärdesproblem och minsta-kvadratmetoden, Matris- och vektornormer, ortogonalisering, projektion, matrisfaktoriseringar, direkta och iterativa lösare, konditionstal, stabilitet hos en metod, komplexitet hos en algoritm, Tillämpning av ovanstående begrepp för att konThe course covers: Direct and/or iterative solution methods for various linear algebra problems such as linear systems of equations, eigenvalue problems and the least-squares method,  Matrix and vector norms, orthogonalisation, projection, matrix factorisations, direct and iterative solvers, condition numbers, stability of a method, complexity of an algorithm,  Applying these con

Du kommer att studera viktiga händelser och idéer i modern judisk historia ur kritiska perspektiv och i en bredare historisk kontext. I den första delkursen fokuserar vi på det sociala, kulturella, religiösa och politiska livet för judar i Öst- och Centraleuropa. Här får du särskilt lära dig om genus, sekularisering och nationalism. Den andra delkursen handlar om migrationsvägar bortom Öst- och CeYou will study important events and ideas in modern Jewish history from critical perspectives and within a broader historical context. In the first module, we focus on the social, cultural, religious, and political life of Jews in Eastern and Central Europe. Here, you will particularly learn about gender, secularization, and nationalism. The second module deals with migration routes beyond Eastern

The programme is organised into three different tracks. When applying for the programme, you also select which track you are specialising in. The different tracks share courses to some extent. The process of economic development essentially rests on the interaction of its three pillars: income per capita growth, distribution of the fruits of growth and structural change. The Economic Develop