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BACKGROUND: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predi
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar
Popular Abstract in Swedish Skogar är av stor betydelse ur klimatsynpunkt på grund av deras stora förmåga att binda kol. Skogar på de nordligare breddgraderna spelar en viktig roll med sitt stora kolupptag, men eftersom dessa nordliga skogar troligen kommer att påverkas av klimatförändringarna i hög grad är det osäkert hur framtida kolupptag kommer att utvecklas. Ett varmare klimat kommer sannolikForests are of major importance to climate change mitigation due to their strong capacity to sequester carbon. Nearly half of the terrestrial carbon is stored in forests, and forests contribute to half of the terrestrial primary productivity, with forests in the mid- and high latitude ecosystems as major contributors. These high latitude forests are, however, projected to be strongly influenced by
Transforming growth factor-β (TGFβ) is a potent inhibitor of hematopoietic stem and progenitor cell proliferation. However, the precise mechanism for this effect is unknown. Here, we have identified the transcription factor Gata2, previously described as an important regulator of hematopoietic stem cell (HSC) function, as an early and direct target gene for TGFβ-induced Smad signaling in hematopoi
The quality of spatial analysis is highly dependent on the geo-referencing quality and the definition of the geographic context variables used. However, such information is seldom considered in historical demographic and epidemiological research that includes the geographic context. We investigate a suitable geographic level for geocoding of the population and definition of geographic context vari
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar
This chapter reviews the historical development of the regulation of waste and chemicals in both international law and European Union (EU) law after the 1972 Stockholm Conference as well as some of the subsequent trends and themes. It also highlights the relevant interactions between EU and international law on these issues. The chapter ends with a discussion of how the regulatory frameworks relat
Women are born with thousands of ovarian follicles, yet less than 1% will ovulate a mature oocyte. What distinguishes the 99% of follicles destined for demise from the rare 1% that succeed? Here, we leveraged a unique clinical opportunity, paired follicular fluid samples from small antral follicles containing either a viable or an atretic oocyte within the same patients, to uncover the proteomic d
Lag(1993:387) om stöd och service till vissa funktionshindrade trädde i kraft den första januari 1994 som en rättighetslag. Syftet var att människor med funktionsnedsättning skulle få ökad livskvalitet. Genom lagen ville samhället skapa en möjlighet för de som får insatser ”att leva ett liv som andra”. Lagen var planerad som en del av en helhet, där handikappolitikens generella och individuella deLag (1993:387) om stöd och service till vissa funktionshindrade, which is an Act of individual rights, came into effect in January 1994. Its purpose was to improve the quality of life for people with disabilities and to create opportunities for people with disabilities to enable to live a life like any other. The Act was intended to be a part of a whole in which the general and individual parts of
This thesis investigates the performance dynamics of serial acquirers in the Swedish market, specifically focusing on their ability to realize cost synergies over time. Through an empirical analysis of Swedish firms engaging in mergers and acquisitions (M&A) between 2010 and 2019, we aimed to determine whether serial acquirers exhibit improved synergy realization in subsequent acquisitions com
Biogenic ice-nucleating particles (INPs) can significantly impact mixed-phase clouds by enhancing precipitation and reducing albedo. As Arctic sea ice diminishes, the exposure of open ocean may increase aerosolization rates of marine bioaerosols and INPs. We investigated INP concentrations and microbial communities in ambient marine air, sea bulk water (SBW), and sea surface microlayer (SML) along
Since the first report of the enhanced permeability and retention (EPR) effect, the research in nanocarrier based antitumor drugs has been intense. The field has been devoted to treatment of cancer by exploiting EPR-based accumulation of nanocarriers in solid tumors, which for many years was considered to be a ubiquitous phenomenon. However, the understanding of differences in the EPR-effect betwe
In studies recruited on a voluntary basis, lack of representativity may impair the ability to generalize findings to the target population. Previous studies, primarily based on surveys, have suggested that generalizability may be improved by exploiting data on individuals who agreed to participate only after receiving one or several reminders, as such individuals may be more similar to non-partici
This paper combines theory and data collected from a shadowing study to explore the role of communication and public relations practitioners in reputation management. In seeking to explore the role communication managers have on the reputation of a CEO and the corporate reputation, this study builds on the existing research on roles research and corporate reputation. The theoretical framework conn
