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An immunoelectron microscopic technique using protein A-gold as a specific marker was used for precise intracellular localization of eosinophil granule proteins. Eosinophils from healthy individuals were isolated in metrizamide gradients. Eosinophil cationic protein (ECP) and eosinophil peroxidase (EPO) were clearly located in the matrix of the large crystalloid-containing granules. In addition, E
Family caregivers in palliative care have a need for knowledge and support from health professionals, resulting in the need for educational and supportive interventions. However, research has mainly focused on the experiences of family caregivers taking part in interventions. To gain an increased understanding of complex interventions, it is necessary to integrate the perspectives of health profes
The mechanism of anterior cruciate ligament (ACL) injury is still unclear. To gain this insight, knowledge of the mechanical behaviour of the healthy ACL during activities that may stress the ligament must be investigated in vivo. The goal of this research was to measure ACL strain in vivo during rapid deceleration, a sport type movement that has been previously shown to precede injuries to the AC
In this paper, we investigate the distributional properties of the estimated tangency portfolio (TP) weights assuming that the asset returns follow a matrix variate closed skew-normal distribution. We establish a stochastic representation of the linear combination of the estimated TP weights that fully characterizes its distribution. Using the stochastic representation we derive the mean and variaIn this paper, we investigate the distributional properties of the estimated tangency portfolio (TP) weights assuming that the asset returns follow a matrix variate closed skew-normal distribution. We establish a stochastic representation of the linear combination of the estimated TP weights that fully characterizes its distribution. Using the stochastic representation we derive the mean and varia
Drawing on archival material from the Danish Guinea Company and central administration, this article discusses the uses of the discourse of the law of nature and nations in the Danish-Dutch war of 1776–1778 on the Guinea Coast and its aftermath. It shows how Danish and Dutch administrators drew on the law of nature and nations to justify their competing claims in the war, which in turn hinged on c
Objectives: In India, cervical cancer is the most common cancer among women and makes up for up to 29% of all registered cancer in females. Cancer-related pain is one of the major distressing symptoms for all cancer patients. Pain is characterised as somatic or neuropathic, and the total pain experience is often mixed. Conventional opioids are the backbone of analgesic treatment but are most often
Background: Head and neck cancer patients often experience muscle wasting due to malnutrition and the hypermetabolism of cancer. For those undergoing total laryngectomy (TL), there is the potential for peri-operative complications. Sarcopenia has gained recognition as a prognostic factor in head and neck cancer. However, there is marked variability in the ways sarcopenia is defined and poor charac
BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre
Background: Postoperative management after surgery for perforated peptic ulcer is still burdened by old traditions. All available data for fast-track recovery in this setting are either very unspecific or underpowered. The aim of this study was to evaluate fast-track recovery in this diagnosis-specific context in a larger sample. Methods: Electronic data sources were searched. Eligible studies wer
Background: Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple routes of referral to enable early detection and subsequent future implementation of tailored interventions. Blood- and eye-based biomarkers show promise as low-cost, scalable and patient-friendly tools for early AD detection given their ability to provide information on
The Swedish Quality Registry for Pain rehabilitation (SQRP) is a well-established clinical registry for adult patients with complex chronic pain conditions. SQRP registers patient-reported outcome measures from a majority of specialist chronic pain units/departments in Sweden. Up to four International Classification of Diseases version 10 (ICD-10) diagnoses can be registered in SQRP. The aim of th
Accurate eye tracking is crucial for gaze-dependent research, but calibrating eye trackers in subjects who cannot follow instructions, such as human infants and nonhuman primates, presents a challenge. Traditional calibration methods rely on verbal instructions, which are ineffective for these populations. To address this, researchers often use attention-grabbing stimuli in known locations; howeve
Purpose: This study aimed to investigate various aspects of treatment for retinopathy of prematurity (ROP) in Sweden over the past 14 years, nationally and at a hospital level. Methods: Data on screening and treatment for ROP in infants born in Sweden from 2008 to 2021 were extracted from the national ROP register, SWEDROP. During this period, Swedish screening guidelines were reduced from gestati
Background. To determine whether genetic risk factors for major depression (MD) and alcohol use disorder (AUD) interact with a potent stressor – death of spouse, parent, and sibling – in predicting episodes of, respectively, MD and AUD. Methods. MD and AUD registrations were assessed from national Swedish registries. In individuals born in Sweden 1960–1970, we identified 7586, 388 459, and 34 370
Objective: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for thecare of patients with diseases of the mesenteric and renal arteries and veins, in succession to the first 2017guidelines, with the aim of assisting physicians and patients in selecting the best management strategy.Methods: These guidelines are based on scientific evidence and expert opinio
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2
An Environmental Evaluation of Landfill Systems Case Study from Two Landfills in South Sweden Kuang -Ling Hsiao Supervisor Torleif Bramryd Thesis for the fulfilment of the Master of Science in Environmental Science Lund, Sweden, November 2001 ABSTRACT With the increasing environmental cancerns, the demand of waste management is switching from a problem solution to an integrated system of technical
https://www.lumes.lu.se/sites/lumes.lu.se/files/hsiao_kuang-ling.pdf - 2026-06-30
