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The main objective of this thesis was to identify methods for the detection of ß-lactam resistance in staphylococci, bacteria often causing nosocomial infections. Detection of ß-lactam resistance in these species is difficult due to strong regulation of genes encoding for the two main resistance mechanisms, ß-lactamase production and the penicillin-binding protein (PBP) 2?. ß-lactamase has high af
This paper presents a practical risk analysis method for critical, large-scale IT systems in an organisation. The method is based on reliability block diagram modelling and was adapted to fit the requirements of governmental organisations and to reduce the effort required to capture complex failure behaviour. Through the use of different failure categories the risk analysis can be simplified, the
Objectives: To identify factors that predict the use of community-based home help services in long-term cholinesterase inhibitor (ChEI)-treated patients with Alzheimer’s disease (AD). Methods: The Swedish Alzheimer Treatment Study (SATS) is an open, prospective, non-randomized, multicentre study in a routine clinical setting. Patients with AD living at home at the time of inclusion received treatm
In this paper 3D electromagnetic simulations of an antenna array have been performed. The array is intended for automotive radar applications at 24 GHz. It is constructed from dipole antenna element patches, which are fed in the center by a differential signal. The dipole antenna element patches are simulated assuming a standard off the shelf substrate. They have a standing wave ratio less than 3
The purpose of this work is the investigation of some constitutive and configurational aspects of phenomenological model formulations for a class of materials with history-dependent gradient microstructure. The assumption that the behavior of a material point is affected by history-dependent processes in a finite neighbor of this point yields an extended continuum characterized by non-simple mater
Background: The wide range of antibody specificity and affinity results from the differing shapes and chemical compositions of their binding sites. These shapes range from discrete grooves in antibodies elicited by linear oligomers of nucleotides and carbohydrates to shallow depressions or flat surfaces for accommodation of proteins: peptides and large organic compounds. Objectives: To determine t
BACKGROUND: We report the surgical treatment of a consecutive series of scan negative patients with the intention of unilateral parathyroid exploration with the aid of intraoperative quick PTH (qPTH).MATERIALS AND METHODS: The study included 35 consecutive sestamibi scan negative patients (27 women, eight men) with sporadic pHPT subjected to first time surgery. Median age was 70 years and median p
In Sweden it is now recognized that while teaching should be based on research and proven experience, research-based practice is limited in scope, and classroom teaching is not always informed by findings from educational research. To address this problem, and to develop and test sustainable models of researcher-practitioner collaboration, the Swedish Government has introduced a national system of
Sub-THz frequencies are tomorrow's hot research area in mobile communication. However, in this range of frequencies the systems are complex, and it is hard to explore various system architectures and correlate the system-level solutions with circuit-level performances and requirements. This paper presents a scalable testbench in MATLAB/Simulink for sub-THz hybrid beamforming receivers. The testben
Purpose: Accuracy investigation of volumetric navigators for motion correction, with emphasis on geometric EPI distortions at ultrahigh field. Methods: High-resolution Dixon images were collected in different head positions and reconstructed to water, fat, T2*, and B0 maps. Resolution reduction was performed, and the T2* and B0 maps were used to apply effects of TE and EPI distortions to simulate
Although renovation costs can lead to rent increases in energy retrofitting, it is often assumed that reductions in energy costs will counterbalance the rent increase. In Swedish multifamily housing, energy costs for heating are however generally included as a fixed component in the monthly rent, meaning that the rent increase after energy retrofitting corresponds to the net change in rent level a
Background. Persistent intolerable pain is still an unsolved issue with a huge socioeconomic impact. To develop appropriate treatments, it is crucial to understand the complex mechanisms underlying pain and how they change during sustained pain stimuli or during pathological conditions. In particular, it is essential to clarify how the endogenous analgesic centres which are present in the brain, s
Cells adhering onto surfaces sense and respond to chemical and physical surface features. The control over cell adhesion behavior influences cell migration, proliferation, and differentiation, which are important considerations in biomaterial design for cell culture, tissue engineering, and regenerative medicine. Here, we report on a supramolecular-based approach to prepare reversible self-assembl
Neuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. In the case of Parkinson’s disease (PD), the induction of motor complications by L-DOPA pharmacotherapy is generally regarded as an example of maladaptive plasti
