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Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov
Background Acute pyelonephritis is a common infection in adult women, but there is a paucity of controlled trials of its treatment and the optimum duration of antibiotic treatment has not been properly defined. We compared the efficacy of ciprofloxacin for 7 days and 14 days in women with community-acquired acute pyelonephritis. Methods In a prospective, non-inferiority trial undertaken at 21 cent
Objective: To describe and compare speech and phonology at age 3 years in children born with unilateral complete cleft lip and palate treated with three different methods for primary palatal surgery. Design: Prospective study. Setting: Primary care university hospitals. Participants: Twenty-eight Swedish-speaking children born with nonsyndromic unilateral complete cleft lip and palate. Interventio
The effects of combustion phase and fuel on smoke particle emissions from a wood stove operated with three different wood fuels and from a corn stove were investigated. A single-particle mass spectrometer (aerosol time of flight mass spectrometer (ATOFMS)) was used for time-and size-resolved chemical signatures and a scanning mobility particle sizer (SMPS) was used for online mobility size distrib
Objective: Compare the impact of two interventions, a web-based support and a folder support, for young persons who care for people who suffer from mental illness. Methods: This study was a randomized control trial, following the CONSORT statements, which compared the impact of two interventions. Primary outcome variable was stress, and secondary outcome variables were caring situation, general se
The time-dependent process of raindrop freezing is described in a general form, including thermodynamic effects from the accretion of cloud liquid and cloud ice. Freezing drops (FDs) larger than 80 m (and their water mass) are represented explicitly in a cloud model with spectral bin microphysics. FDs consist of interior water covered by ice initially. Possibilities of both dry (icy surface) and w
Angiogenesis is a target in the treatment of ovarian cancer. Nintedanib, an oral triple angiokinase inhibitor of VEGF receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptor, has shown activity in phase 2 trials in this setting. We investigated the combination of nintedanib with standard carboplatin and paclitaxel chemotherapy in patients with newly diagnosed advan
The role of thalidomide for previously untreated elderly patients with multiple myeloma remains unclear. Six randomized controlled trials, launched in or after 2000, compared melphalan and prednisone alone (MP) and with thalidomide (MPT). The effect on overall survival (OS) varied across trials. We carried out a meta-analysis of the 1685 individual patients in these trials. The primary endpoint wa
The study investigates the extent to which the perceived physical environmental quality of housing facilities for people with severe mental illness accounts for perceived social environmental quality. Twenty facilities were assessed by people with psychiatric disabilities (residents), staff, and experts with regard to the physical environmental aspects of visual pleasantness, indirect environmenta
Popular Abstract in Swedish Bukspottkörteln (pankreas) består av en sekretorisk (exokrin) del, som producerar pankreassaft innehållande olika matspjälkningsenzymer vilka medverkar vid nedbrytningen av födan i tarmen, samt en hormoninsöndrande (endokrin) del, som producerar insulin och andra hormon vilka reglerar näringsomsättningen i kroppen. Vid en underproduktion av enzymer, exokrin pankreatisk Exocrine pancreatic insufficiency (EPI), resulting from disease (e.g. cystic fibrosis, chronic pancreatitis) or surgery (e.g. pancreectomy or pancreas duct ligation), leads to disorders in the digestive system, such as, maldigestion, malabsorption and finally malnutrition. Pancreatic duct-ligated (PDL) pigs have been used as a suitable large-animal model to study the conditions and treatment of EP
It is of central interest in membrane proteomics to establish methods that combine efficient solubilization with enrichment of proteins and intact protein complexes. We have investigated the quantitative and qualitative solubilization efficiency of five commercially available detergents using mitochondria from the yeast Saccharomyces cerevisiae as model system. Combining the zwitterionic detergent
This study investigated the rationale of boron neutron capture therapy (BNCT) for the treatment of Grade III and IV astrocytoma. The European Community joint research program on BNCT plans to use sulfhydryl boron hydride (BSH) in clinical trials. The work presented here, examines the performance of BSH in eight patients with Grade III and IV astrocytoma using a measurement technique which precisel
Objective. The popliteal artery is, after the aorta, the most common site for aneurysm formation. Why the popliteal artery is more susceptible than other peripheral muscular arteries is unknown. An important factor may be differences in arterial wall composition as compared with other peripheral muscular arteries, which in turn affect wall properties. These are however unknown. We studied the mech
Continues positive airway pressure (CPAP) is recommended for treatment of sleep apnoea (SA) in patients with congestive heart failure (CHF) but is not easily tolerated resulting in poor patient compliance. Mandibular advancement device (MAD) is designed to inhibit pharyngeal airway (PAW) obstruction and may be a valuable alternative. It has been proposed that MAD exerts its effect by increasing PA
Background It is only recently that comorbidity in ADHD has come to the forefront as one of the most important aspects of the disorder. It is agreed that, often, these problems are at least as important as ADHD in contributing to the longer term outcome in the individual child. Objective To provide the reader with basic information about clinics and treatment of comorbidity in ADHD. Method Revie
Popular Abstract in Swedish Den psykiatriska vården har genomgått radikala förändringar under de två senaste decennierna. Antalet platser inom den slutna vården har mer än halverats. Målsättningen från politikerna både på det nationella och internationella planet har varit att stänga mentalsjukhusen och erbjuda öppnare och humanare vårdformer samt öka utbudet av boendeformer för personer som drabbThis study investigated psychosocial environment, needs, quality of life and social network for persons with severe mental illness in supported housing in the community. Eighty-three persons with severe mental illness living in three different types of housing setting accepted to participate in the interviews, which took place between December 1997 and April 2000. These settings were: inpatient se
OBJECTIVES: To determine the ability of transvaginal ultrasound, with or without saline infusion, to detect focally growing lesions in the uterine cavity in women with postmenopausal bleeding and endometrium > 5 mm, and to determine the accuracy of conventional ultrasound, saline contrast sonohysterography and diagnostic hysteroscopy under general anesthesia to diagnose endometrial polyps, submuco
