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Objective: To describe and compare speech and phonology at age 3 years in children born with unilateral complete cleft lip and palate treated with three different methods for primary palatal surgery. Design: Prospective study. Setting: Primary care university hospitals. Participants: Twenty-eight Swedish-speaking children born with nonsyndromic unilateral complete cleft lip and palate. Interventio
Tissue factor (TF)-mediated protease activated receptor (PAR)-2 signaling is associated with a pro-migratory, invasive and pro-angiogenic phenotype in experimental models of breast cancer, and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these findings are unknown. Here, we provide first in vivo evidence of TF phosphoryl
Hollow fiber supported liquid membrane sampling and speciation of lead(II) from aqueous solution using a selective carrier (Kelex 100) is studied. An optimization of different variables affecting permeation performance (chemical conditions of the sampling module - pH, concentration and nature of the acceptor phase, extractant concentration; membrane impregnation form; sampling time; and hollow fib
We present the results of a search for gravitational waves associated with 154 gamma-ray bursts (GRBs) that were detected by satellite-based gamma-ray experiments in 2009-2010, during the sixth LIGO science run and the second and third Virgo science runs. We perform two distinct searches: a modeled search for coalescences of either two neutron stars or a neutron star and black hole, and a search f
A portable high resolution soft x-ray and extreme ultraviolet (EUV) spectrometer has been developed for spectroscopic research at the Shanghai Electron Beam Ion Trap (EBIT) laboratory. A unique way of aligning the grazing incidence spectrometer using the zero order of the grating is introduced. This method is realized by extending the range of the movement of the CCD detector to cover the zero ord
Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive responses of cancer cells to hypoxia offers opportunities for tumour specific therapies. The aim of this
Hybridization is observed frequently in birds, but often it is not known whether the hybrids are fertile and if backcrossing occurs. The breeding ranges of the great reed warbler (Acrocephalus arundinaceus) and the clamorous reed warbler (A. stentoreus) overlap in southern Kazakhstan and a previous study has documented hybridization in a sympatric population. In the present study, we first present
Many patients on renal replacement therapy (RRT) require parathyroidectomy (PTX). Trends and current rates of PTX on a national level are not known. Furthermore, it is not completely clear which factors influence rates of PTX. Thus, our aim was to investigate the incidence, regional distribution and factors associated with PTX as well as possible temporal changes, in the Swedish RRT population.
The article discusses the impact of comparative/historical philology upon the question of nuclear semiotics, i.e. the field of how humanity is to communicate information about nuclear waste storage into the distant future and its (presumably human) inhabitants. It also turns this perspective on its head and discusses possible insights in the other direction – what Nuclear Semiotics can teach histo
A surface-sediment survey of pigments in 100 lakes in the Scandes Mountains, northern Sweden, was combined with a reconstruction of Holocene sedimentary pigments from Lake Seukokjaure to assess the major factors regulating phototrophic communities, and how these controls may have changed during the period from the deglaciation (similar to 9700 cal. years BP) to the present. The study area covers a
Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause of death and comorbidities. Kaplan-Meier and Cox pro
Svår, elakartad och längre gången cancer är ett stort problem i förhindrande av spridda tumörceller i kroppen. I detta sjukdomsstadium är oftast en lindrande (palliativ) behandlingsform enda vägen att välja för att hjälpa patienten. För närvarande sker detta genom att patienten får genomlida extern strålbehandling eller cellgiftsbehandling. Radioaktivt märkta och ”målsökande” antikroppar injicer
The witness is universally considered to be one the most instruments to ascertain the truth in criminal proceedings or as Bentham says “Witnesses are the eyes and the ears of justice.” Under the International Criminal Court (ICC)’s legal framework, witnesses who testify before the Court, persons at risk and their interaction with the Court because of testimony at the ICC are entitled to the protec
Purpose – This paper aims to contribute to the tactical and operational decision making of manufacturing and logistics operations by providing novel insights into modelling and simulation, based on complex adaptive systems (CAS). Design/methodology/approach – The research approach is theoretically based on CAS with agent-based modelling (ABM) as the implementation method. A case study is presented
We investigate the CCN activity of freshly emitted biomass burning particles and their hygroscopic growth at a relative humidity (RH) of 85%. The particles were produced in the Mainz combustion laboratory by controlled burning of various wood types. The water uptake at sub- and supersaturations is parameterized by the hygroscopicity parameter, κ (c.f. Petters and Kreidenweis, 2007). For the wood b
Pressure transduction to the wound bed in negative pressure wound therapy (NPWT) is crucial in stimulating the biological effects ultimately resulting in wound healing. In clinical practice, either foam or gauze is used as wound filler. Furthermore, two different drainage techniques are frequently employed. One involves the connection of a non-perforated drainage tube to the top of the dressing, w
