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Water molecules play important roles in all biochemical processes. Therefore, it is of key importance to obtain information of the structure, dynamics, and thermodynamics of water molecules around proteins. Numerous computational methods have been suggested with this aim. In this study, we compare the performance of conventional and grand-canonical Monte Carlo (GCMC) molecular dynamics (MD) simula
Increases in temperature related to global warming have important implications for organismal fitness. For ectotherms inhabiting temperate regions, ‘winter warming’ is likely to be a key source of the thermal variation experienced in future years. Studies focusing on the active season predict largely positive responses to warming in the reptiles; however, overlooking potentially deleterious conseq
Pulse transformer size is fundamentally linked to application pulselength, pulse power and pulse rise time. In considering long-pulse high-power applications, it has earlier been demonstrated that the large voltage-time integral associated with long-pulse operation in combination with the severe pulse rise time required to ensure high pulse efficiency strictly limits the number of transformer wind
Objective: Although targeted approaches have become available in second- and third-line settings, platinum-based chemotherapy remains the standard first-line treatment for advanced muscle-invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance. Methods: In this study, we established a routine compatible method for the molecular classificati
The upcoming Cherenkov Telescope Array (CTA) ground-based gamma-ray observatory will open up our view of the very high energy Universe, offering an improvement in sensitivity of 5-10 times that of previous experiments. NectarCAM is one of the proposed cameras for the Medium-Sized Telescopes (MST) which have been designed to cover the core energy range of CTA, from 100 GeV to 10 TeV. The final came
Background: Rectal washout (RW) is routinely performed during anterior resection (AR) for rectal cancer to reduce local recurrence (LR), although is sometimes not performed during minimally invasive surgery (MIS) procedures due to technical challenges and time consumption. The aim was to investigate the impact of RW on the oncological outcome after AR for rectal cancer in a registry cohort. Method
The fundamental importance of membrane proteins in drug discovery has meant that membrane mimetic systems for studying membrane proteins are of increasing interest. One such system has been the amphipathic, negatively charged poly(styrene-co-maleic acid) (SMA) polymer to form "SMA Lipid Particles" (SMALPs) which have been widely adopted to solubilize membrane proteins directly from the cell membra
The potential of geothermal energy for energy transition is increasingly recognized by governments around the world. Whether geothermal energy is a sustainable source of heat and/or electricity depends on how it is deployed in specific contexts. Therefore, it is striking that there is only limited attention to geothermal energy from a social science and humanities (SSH) perspective. Geothermal ene
This chapter explores the facilitation of reflective practice to aid and guide educators seeking to develop these soft skills and to assist them in developing educational programmes in the international classroom. Knowledge about learning, teaching, and education is a basic requirement. Few institutions, if any, would dispute the need for teaching staff to have an inventory of skills and expertise
This paper presents a scoping review of methods for fire evacuation training in buildings. It adopts the PRISMA methodology (Transparent Reporting of systematic Reviews and Meta-Analyses) and systematically identifies 73 sources among scientific literature published between 1997 and 2022. It was found that the literature is dominated by research on modern technology (Augmented Reality, Virtual Rea
Enzyme-responsive hydrogels, formed by step growth photopolymerization of biscysteine peptide linkers with alkene functionalized polyethylene glycol, provide interesting opportunities as biomaterials and drug delivery systems. In this study, we developed stimuli-responsive, specific, and cytocompatible hydrogels for delivery of anti-inflammatory drugs for the treatment of inflammatory skin disease
In 1968, Swedish insurance company Folksam launched the information campaign Front mot miljöförstöringen (“Front against Environmental Degradation”). The campaign culminated in 1969 with large public hearings where young people addressed local politicians and industry leaders about environmental problems. Throughout this campaign, the aim was to activate youth and make them co-creators of large-sc
Clinical pain is often linked to poor body mechanics, with individuals sometimes presenting multiple painful disorders. Such disorders may be influenced by behaviors that affect the general resiliency and health of the musculoskeletal system. We aimed to develop a self-reported scale using the Malmö Diet and Cancer Study questions on work-related body mechanical exposures. An expert panel identifi
The release of inorganic elements, especially K, Cl, and S, can cause severe damage to biomass conversion devices, such as slagging, fouling, or corrosion. A predictive model for the release of K-Cl-S elements can be used to enhance the design and operating conditions of biomass conversion devices. In this study, a detailed model is developed that includes 12 solid species and 13 reactions, which
Transition metals such as copper and zinc are essential elements required for the survival of most organisms, from bacteria to humans. Yet, elevated levels of these elements are highly toxic. The Copper TRansporter protein family (CTRs) represents the only identified copper uptake proteins in eukaryotes and hence serves as key components for the maintenance of appropriate levels of the metal. More
BACKGROUND: X-ray micro-tomography (μCT) is a powerful non-destructive 3D imaging method applied in many scientific fields. In combination with propagation-based phase-contrast, the method is suitable for samples with low absorption contrast. Phase contrast tomography has become available in the lab with the ongoing development of micro-focused tube sources, but it requires sensitive and high-reso
Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear sections of adult rat brains for subsequent high-resolution confocal imaging. The protocol does not require toxic reagents or specialized equipment. We also provide instructions for culturing of rat brain slices free floating on permeable cu
Seaweeds (macroalgae) are gaining attention as potential sustainable feedstock for the production of fuels and chemicals. This comparative study focuses on the characterization of the microbial production of alcohols from fermentable carbohydrates in the hydrolysate of the macroalgae Laminaria digitata as raw material. The potential of a hydrolysate as a carbon source for the production of selecte
Structured triacylglycerols (STAG) with desired properties can be synthesized by transesterification using immobilized lipases. Herein, the effect of immobilization conditions and support material on the immobilization yield, specific activity and regioselectivity of lipases from Rhizomucor miehei (RML) and Rhizopus oryzae (ROL) in the production of STAG, are evaluated. Four different support mate
