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Rapid fabrication of PMMA/PET-E/PMMA for thermoplastic microfluidic membrane devices

We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solv

Regulation of eukaryotic aquaporins

Membrane-bound water channels known as aquaporins (AQPs) facilitate water transport across biological membranes along osmotic gradients. Since all living cells depend on their ability to maintain water homeostasis, this must be tightly regulated. In eukaryotes, this is achieved by gating, which involves a conformational change of the protein, thereby physically blocking water transport, or by traf

Delayed postischemic hypoperfusion : Evidence against involvement of the noradrenergic locus ceruleus system

This study explores the possibility that the delayed hypoperfusion observed after an ischemic insult might be due to vasoconstriction induced by the release of noradrenaline from nerves originating in the locus ceruleus. Bilateral 6-hydroxydopamine lesions of the ascending bundles from the locus ceruleus were carried out in the caudal mesencephalon of rats. Local CBF was measured with an autoradio

Sexual differentiation and development

Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to i

Modelling the dynamics of wastewater treatment processes / Modellering av dynamiska förlopp i vattenreningsprocesser

The main objective of the paper is to briefly describe and exemplify some of the work that has been carried out within the STAMP project at IEA at Lund Institute of Technology within the field of mathematical modeling of wastewater treatment (WWT) processes. Three main areas have been identified - reduced-order models of the activated sludge process, modelling of biofilm processes including some e

Från planering till resultat - om utvärderingsforskning i Sverige

Att en specifik utvärderingsforskning knappast existerade i Sverige före mitten av 1970-talet beror bl a på att socialpolitiska reformer normalt föregåtts av en planerings- och beslutsprocess som inneburit omfattande politisk kontrol och värdering, såväl före som under själva genomförandet. Förändringarna inom offentlig sektor, där det tidligare planeringstänkandet ersatts av en mål- och resultats

Hydrologiska forskningsbehov under 90-talet

Environmental problems and technical systems in the society are fundamentally related to hydrology. Hydrology is a very comprehensive concept. In fact, there are at least ten independent disciplines within hydrology. Classical hydrology is a descriptive science with the water balance equation as almost the only means of quantifying computations. Hydrodynamics have now to some extent been introduce

Degradation of Covariance Reconstruction-Based Adaptive Beamformers

We show that recent robust adaptive beamformers, based on reconstructing either the noise-plus-interference or the data covariance matrices, are sensitive to the noise-plus- interference structure and degrade in the typical case when interferer steering vector mismatch exists, often performing much worse than common diagonally loaded sample covariance matrix based approaches, even when signal-of-i

Patient-specific Glucose Metabolism Models for Model Predictive Control of T1DM Glycemia

The development of a predictive control algorithm for glycaemia regulation in diabetic subjects requires patient-specific models of the glucose metabolism which are physiologically relevant, parsimonious, yet able to accurately forecast blood glucose. Given the measured data: total plasma insulin [mIU/L]; plasma glucose [mg/dL]; plasma glucose rate of appearance after intestinal absorption [mg/kg