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Disseminated melanoma is an aggressive disease with fatal outcome. Better understanding of the underlying biology is needed to find effective treatment. We applied microarray-based comparative genomic hybridization, gene expression and CpG island methylation analysis of primary tumors and multiple metastases from five melanoma patients with the aim of analyzing the molecular patterns of melanoma p
Recreational physical activity in 25-year-old women in Sweden increases bone mineral density (BMD) in the trochanter by 5.5% when combining regularity and impact. Jogging and spinning were especially beneficial for hip BMD (6.4-8.5%). Women who enjoyed physical education in school maintained their higher activity level at age 25. INTRODUCTION: The aims of this study were to evaluate the effects of
Mantle cell lymphoma (MCL) has a heterogeneous clinical course. The recently proposed Mantle Cell Lymphoma International Prognostic Index (MIPI) predicted the survival of MCL better than the International Prognostic Index in MCL patients treated with conventional chemotherapy, but its validity in MCL treated with more intensive immunochemotherapy has been questioned. Applied here to 158 patients o
Objective: The complement system is activated in human atherosclerotic lesions and may hence aggravate local inflammation. We studied the presence and localization of C4b-binding protein (C4bp), the major inhibitor of the classical complement pathway, in human atherosclerotic lesions in relation to complement activation products and protein S, which circulates in complex with C4bp. Methods and res
In recent years a growing amount of research has been conductedin the area of workplace incivility. Whereas many studies havefocused on the victims and the consequences of incivility, littleattention has been paid to the perpetrators and antecedents ofworkplace incivility. This study aims to identify possibleantecedents of workplace incivility, by investigating organizationalaspects as well as the
2015-09-14 MVET01 Kursbeskrivning och schema Kursbeskrivning MVET01, 15 hp, HT 15 Tillämpad Industriell Miljöekonomi Kurstid: 2015-11-02 till 2016-01-17 (juluppehåll 2015-12-22 – 2015-01-06) Kursansvarig: Charlotte Leire, charlotte.leire@iiiee.lu.se, tel. 046-2220248, mobil 0708-381045 Upprop & introduktion: Mån 2 nov 2015, Ekologihuset (Mossen Östra), kl 10.15 Kurstema och beskrivning Kursen syft
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mvet01_schema_h15_v3.pdf - 2026-07-17
2015-09-14 MVET01 Kursbeskrivning och schema Kursbeskrivning MVET01, 15 hp, HT 15 Tillämpad Industriell Miljöekonomi Kurstid: 2015-11-02 till 2016-01-17 (juluppehåll 2015-12-22 – 2015-01-06) Kursansvarig: Charlotte Leire, charlotte.leire@iiiee.lu.se, tel. 046-2220248, mobil 0708-381045 Upprop & introduktion: Mån 2 nov 2015, Ekologihuset (Mossen Östra), kl 10.15 Kurstema och beskrivning Kursen syft
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mvet01_schema_v4.pdf - 2026-07-17
Icke-statliga organisationer är inflytelserika aktörer i världspolitiken och utvecklingsarbeten. Under det senaste decenniet har allt fler icke-statliga organisationer, internationella och nationella, rapporterat om kränkningar av de mänskliga rättigheterna för HBTQIAP+ personer och de utmaningar som de möter i deras liv. Hur de rapporterar om dessa frågor är viktiga eftersom språk och diskurs harNGOs are influential actors in world politics and development efforts. During the last decade increasing numbers of NGOs, international and national, have been reporting on the violations of the human rights of LGBTQIAP+ persons and the challenges these people face in their lives. How they report on these issues matters since language and discourse have an influence over whose voices are heard and
Background: Bacillus Calmette-Guerin (BCG) instillation is regarded as the most effective bladder-sparing treatment for patients with high-grade T1 tumours and carcinoma in situ (CIS). The major problem with this therapy is the side-effects, making maintenance therapy difficult, even impossible, in a proportion of patients. Thus, alternative schedules and drugs have been proposed. Objective: To co
Climate change is one of the most pressing issues researched in Sustainability Science. Even though risks and consequences have been shown, actions to reduce emissions have been unsuccessful. UNFCCC is the global center for climate change policy and the host of the greatest concerted will to fight climate change, the Paris Agreement. Even with the hopeful aim and goals of the agreement, global emi
Background: The prevalence of urinary incontinence (UI) and fecal incontinence (FI) are conditions that increase with age. Apart from few larger studies data on prevalence and severity of UI and FI is scarce, especially among the > 80 yrs. and data of birth cohort effects is lacking. Methods: The purpose of this study was to evaluate birth cohort effects on prevalence of UI and FI in the general o
Nemo-like kinase (NLK) is a member of the mitogen-activated protein kinase family of kinases and shares a highly conserved kinase domain with other mitogen-activated protein kinase family members. The activation of NLK contributes to the pathogenesis of Diamond–Blackfan anemia (DBA), reducing c-myb expression and mechanistic target of rapamycin activity, and is therefore a potential therapeutic ta
The molecular form and immunochemical properties of the J chain populations released on reduction and carboxymethylation of normal human plasma, milk, saliva and of plasma containing IgA or IgM M-components were investigated. A procedure was devised to release the entire J chain population from these various sources and to produce immunochemically identical J chain populations containing only J ch
Protein HC, an extremely charge-heterogeneous lipocalin, carries a yellow-brown fluorescent chromophore of unknown structure covalently bound at an unidentified site of its polypeptide chain. Two chromophore-carrying peptides with 60% of the chromophore material (defined as material absorbing light at 330 nm) were isolated from pepsin-digested native human protein HC by reversed-phase high perform
Recent progress on deep learning (DL)-based medical image segmentation can enable fast extraction of clinical parameters for efficient clinical workflows. However, current DL methods can still fail and require manual visual inspection of outputs, which is time-consuming and diminishes the advantages of automation. For clinical applications, it is essential to develop DL approaches that can not onl
This study explored factors associated with interest in taking PrEP among men who have sex with men (MSM) attending HIV testing venues in Sweden. Data from 658 HIV-negative respondents, surveyed by a questionnaire at six sites, were analyzed descriptively and by univariable and multivariable logistic regression. A total of 453 (68.8%) of the respondents expressed interest in taking PrEP. Reporting
In very recent years, growing efforts have been devoted to the development of all-polymer solar cells (all-PSCs). One of the advantages of all-PSCs over the fullerene-based PSCs is the versatile design of both donor and acceptor polymers which allows the optimization of energy levels to maximize the open-circuit voltage (Voc). However, there is no successful example of all-PSCs with both high Voc
The article summarizes the results of work since 2010 to develop non- destructive energy dispersive X-ray fluorescence analysis (EDXRF) as a non-destructive method for determining the provenience of flint in northern Europe. Some 40 localities from Sweden, Denmark, Germany, Poland, and Ukraine have been sampled and analyzed. Trace elements have not proven particularly effective in drawing distinct
Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recov
BACKGROUND: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.OBJECTIVE: We investigated the relation between dietary vitamin K(1) intake, APOE polymorphisms, and markers of bone health.DESIGN: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) in a cohort of Scottish wome
