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Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtai
Lithium depletion and enrichment in the cosmos is not yet well understood. To help tighten constraints on stellar and Galactic evolution models, we present the largest high-resolution analysis of Li abundances A(Li) to date, with results for over $100\, 000$ GALAH (Galactic Archeology with HERMES) field stars spanning effective temperatures $5900\, \mathrm{K} \lesssim T_{\mathrm{eff}}\lesssim 7000
We present an advanced approach for single-cell analysis of circulating tumor cells (CTCs) by integrating an acoustofluidic chip for sample preparation, including simultaneous acoustophoretic separation and enrichment of the separated cells, onto an electroactive microwell array (EMA) for single-cell arraying. The integrated device shows highly efficient cell recovery of target cells (82.5%) and d
Stem cell transplantation is a cornerstone in the treatment of blood malignancies. The most common method to harvest stem cells for transplantation is by leukapheresis, requiring mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow into the blood. Identifying the genetic factors that control blood CD34+ cell levels could reveal new drug targets for HSPC mobili
Maternal vaccination, resulting in transfer of protective IgG across the placenta, represents a promising strategy to prevent neonatal disease caused by group B Streptococcus (GBS). The prototype vaccine GBS-NN, a fusion protein consisting of the N-terminal domains of the alpha-like protein (Alp) family members AlphaC and Rib, has been shown to display a good safety profile and to elicit a strong
Lean construction principles have been successfully adopted in a variety of industries to increase project management quality. This paper addresses maintenance planning in Sweden and analyses its effectiveness in the framework of lean construction principles. To investigate the status and improvement potential of maintenance contractors’ performance, the study focuses on the detailed planning proc
Estimating age distributions, or star formation histories, of stellar populations in the Milky Way is important in order to study the evolution of trends in elemental abundances and kinematics. We build on previous work to develop an algorithm for estimating the age-metallicity distribution which uses the full age-metallicity probability density functions (PDFs) of individual stars. No assumptions
Analyzes research and innovation in the European Union against the backdrop of the COVID pandemic, Brexit, global challenges and a changing international landscape.
Background: Documentation of older people’s end-of-life care should cover the care given and provide an overview of their entire situation. Older people approaching the end of life often have complex symptoms, live with bodily losses, and face an unknown future in which existential aspects come to the forefront. Knowledge of the existential aspects recorded in palliative care documentation is spar
Science, technology and innovation (STI) are widely perceived as critical factors for sustainable development. The 2030 Agenda defined STI as the central means of sustainable development. The Sustainable Development Goal 17 has three targets that focus on technology transfer, and the United Nations Technology Facilitation Mechanism was launched to promote multi-stakeholder collaboration. While STI
Registry-based randomised controlled trials (R-RCTs) represent a paradigm shift in research, with the potential to accomplish pragmatic but large trials with high external validity. In this paper, we review our experiences from planning and performing the REgistry-based randomised controlled trial of treatment Duration and mortality in long-term OXygen therapy (REDOX) trial, the first R-RCT within
Podcast "Öppet fall" från Lunds universitet, Juridiska fakulteten: Kan kungen få sitt körkort indraget om han kör för fort? Äger kungen Stockholms slott? Kan kungen blockera ett regeringsskifte? Får kungen konvertera och bli muslim? En panel med jurister från Lunds universitet svarar på frågor om kungen och juridiken.
ObjectivesUncertainty among healthcare providers about patients’ ability to make care decisions is a barrier to shared decision-making. We aimed to assess the self-reported decision-making ability of patients with cancer at the end of life.MethodsData from 11 countries of adults with a limited life expectancy and cancer as the primary diagnosis were used. Participants completed a questionnaire, in
Group A Streptococcus (GAS) forms highly deformable aggregates with broad variations in size and morphology, complicating controlled separation and biological analysis. Reliable methods to isolate fractions of GAS clusters with defined properties are essential for studying host–pathogen interactions that depend on cluster size. Here, we present a simple deterministic lateral displacement (DLD) mic
Tomographic X-ray imaging techniques offer novel opportunities for studying membranes and membrane processes in 3D on a spatial resolution not seen before. Traditional 2D imaging techniques used to characterise membranes have limitations that can be overcome by tomographic X-ray imaging. Tomographic X-ray imaging can provide information in 2D/3D or 4D (3D plus time) on membranes, membrane modules,
Our understanding of how class-switch recombination (CSR) to IgA occurs in the gut is still incomplete. Earlier studies have indicated that Tregs are important for IgA CSR and these cells were thought to transform into follicular helper T cells (Tfh), responsible for germinal center formation in the Peyer's patches (PP). Following adoptive transfer of T-cell receptor-transgenic (TCR-Tg) CD4 T cell
Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as t
Requirements engineering for commercial off-the-shelf software packages entails special challenges. This paper presents preliminary results from an empirical study investigating these challenges through a qualitative approach using semi-structured interviews. The survey is exploratory with the objective of eliciting relevant topics for further research. Seven employees at five software companies w
