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Society has become more aware of how overuse of chemical compounds in agriculture can affect the environment causing negative effects to ecosystem services. Due to this awareness, in recent years new regulation of pesticide use has been developed and some pesticides have been banned. With the new regulation, alternative methods of pest control have been advised which may also be easier to implemen
Technologies to develop and evolve the function of proteins and, in particular, antibodies have developed rapidly since the introduction of phage display. Importantly, it has become possible to identify molecules with binding properties that cannot be found by other means. A range of different approaches to create general libraries that are useful for the selection of such molecules specific for e
Stress-related disorders are a frequent cause for sick leave, with consequences such as great distress and adverse economic effects for the affected person and substantial costs for society. Identifying effective interventions that facilitate return to work is thus important. The aim of this study was to evaluate the effectiveness of the 16-week Redesigning Daily Occupations program as a work reha
Objective: Assessing psychological pain is crucial for evaluating suicide risk. This study examined differences in psychological pain between patients with suicide attempts, those with suicidal ideation, clinical, and non-clinical controls using a newly translated German version of the Mee-Bunney Psychological Pain Assessment Scale (MBPPAS). Method: A cross-sectional study was conducted with two i
A search for heavy pseudo-scalar (A) and scalar (H) Higgs bosons decaying into a top-quark pair (tt¯) has been performed with 140 fb−1 of proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a centre-of-mass energy of s = 13 TeV. Interference effects between the signal process and Standard Model (SM) tt¯ production are taken into account. Final states with
Most statements regarding human modeling tools efficiency are based on perceived time. No structured time observation of task activities performed by a simulation engineers working with the tools are previous performed. The aim of the study is to identify digital human modelling tool users’ activates and measure the time distribution of the activities. Furthermore, measured time distribution is co
Under årens lopp har människan gjort stora landvinningar inom läkemedelsforskning, vilket har lett fram till avancerade läkemedel som idag tas för givna. Avancerade läkemedel sätter dock höga krav på tillverkarna av läkemedel, vilket har lett till att framtagandet av nya läkemedel är en ganska komplicerad process. Faktum är att dagens läkemedelsutveckling är så komplex att alla aspekter förmodligePopular Abstract in Swedish Under årens lopp har människan gjort stora landvinningar inom läkemedelsforskning, vilket har lett fram till avancerade läkemedel som idag tas för givna. Avancerade läkemedel sätter dock höga krav på tillverkarna av läkemedel, vilket har lett till att framtagandet av nya läkemedel är en ganska komplicerad process. Faktum är att dagens läkemedelsutveckling är så komplex
Research on human emotions towards large carnivores is often based on self-reported emotions. This study aimed to investigate physiological and behavioral responses to feared animals among people who say that they are fearful or not fearful of brown bear and wolf. Participants were recruited to be bear fearful only (n=8), fearful of both bear and wolves (n=15), or fearful of neither carnivore (n=1
These days, talk of quantum technologies and the coming ‘quantum revolution’ or ‘quantum leap’ is hard to miss. There is a broad agreement that quantum technologies have a high probability of becoming the next disruptive technological development, and the way they should be regulated and the timing of such intervention are issues that are attracting increasing attention. An analysis of how these q
Background: Despite substantial progress in the field of mass spectrometry, there remain barriers to measuring the extracellular vesicles (EVs) proteome in blood plasma. Recent work has shown that isolating EVs can make it possible to detect proteins that have low abundance in plasma. Commonly used EV isolation methods either require large sample volumes and long ultracentrifugation times, or else
Population growth and climate change have accelerated groundwater depletion globally. Interferometric synthetic aperture radar (InSAR) is a fairly new satellite remote sensing technique based on SAR images that offers a high-accuracy monitoring system of land surface motion driven by groundwater level changes in time and space that can never be achieved with point-in-situ measurements. In producti
Supported by a large body of scholarship, it is increasingly orthodox practice for cities to deploy urban greening interventions to address diverse socioenvironmental challenges, from protecting urban ecosystems to enhancing built environments and climate resilience or improving health outcomes. In this article, we expand the theoretical boundaries used to challenge this growing orthodoxy by layin
Aim. - To explore the association between baseline levels of insulin-like growth-factor-binding protein-1 (IGFBP-1), a marker of insulin sensitivity, and the development of type 2 diabetes or impaired glucose tolerance (IGT) in a specifically defined middle-aged population. Methods. - This cross-sectional population-based screening study was conducted in 1989-1990 and included baseline data for 66
Popular Abstract in Swedish När patienten lämnar sjukhuset och återvänder hem efter en operation för kolorektal cancer (tjocktarm och ändtarm) innebär det en stor omställning. De är inte återställda efter den stora bukoperationen och upplever olika symtom som smärta, tarmbesvär och stor trötthet. Eftersom vårdtiderna blir allt kortare har deras återhämtning bara påbörjats på sjukhuset och de kommeThe overall aim of this thesis is to study the experiences of patients and next of kin with regard to information and information needs after being discharged after colorectal cancer surgery. The aim was also to study factors related to this. Different methods were combined in this explorative study in order to obtain diverse types of data. Patients who had undergone surgery for colorectal cancer
Hepatitis B virus (HBV) strains from anti-HBe positive patients often show specific mutations in the precore gene, the core promoter region, or both. The dynamics of seroconversion in relation to the appearance of these mutations has not been studied and compared between defined HBV genotypes. Samples from patients followed during seroconversion from HBeAg to anti-HBe were amplified by polymerase
Objective. Hemophilic arthropathy, with characteristics of inflammatory (rheumatoid arthritis) and degenerative (osteoarthritis) joint damage, occurs at an early age, is associated with minor comorbidity, and is restricted to 3 pairs of large joints. The aim of this study was to determine whether commonly used serum and/or urinary biomarkers of cartilage and bone turnover for which assay kits are
Antibodies directed against a pathogenic microorganism may recognize either protective or non-protective epitopes. Because antibodies elicited by a vaccine must be directed against protective epitopes, it is essential to understand the molecular properties that distinguish the two types of epitope. Here we analyse this problem for the antiphagocytic M protein of Streptococcus pyogenes, using the o
