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The legal status of EU human rights norms is not clearly defined. The initial goals of the European Community were primarily of economic nature, and social and political rights were merely welcomed as secondary effects of the single market aim. Human rights concerns were at the end of the Second World War reserved for the Council of Europe and the founding of the European Convention on Human Right

We describe a novel method for determining weak association constants of oligomeric protein complexes formed transiently under equilibrium conditions. This type of equilibrium process is recognized as being biologically important, but generally hard to study. Heteronuclear spin relaxation rates measured at multiple protein concentrations are analyzed using relaxation rates predicted from hydrodyna

This research confirms previous studies stating that in transition periods people are more likely to change their product preferences and use consumption as a tool to support the new role, as well as to keep and construct stable and harmonious identity. This study contributes to the identity domain of CCT by identifying the changing relationship to possessions in this specific transition and the s

Forskning har visat att handfunktion försämras med stigande ålder och begränsar äldre människors aktiviteter i det dagliga livet. Syftet med studien var att ta reda på i vilka dagliga aktiviteter äldre kvinnor upplever aktivitetsbegränsningar på grund av upplevd nedsatt handfunktion. Studien har en tvärsnittsdesign med kvantitativ ansats där Canadian Occupational Performance Measure (COPM), Quick

Abstract: The purpose of this study was to elucidate the organisation Family First's campaign against the anti-smacking law in New Zeeland. This has been done through a qualitative content analysis of how Family First use arguments and rhetoric in their campaign, and what consequences Family First mean the anti-smacking law has had for the society, the parents and the children and how this con

Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as t

Background: Many patients with psychotic disorders have persistent paranoid ideation and avoid social situations because of suspiciousness and anxiety. We investigated the effects of virtual-reality-based cognitive behavioural therapy (VR-CBT) on paranoid thoughts and social participation. Methods: In this randomised controlled trial at seven Dutch mental health centres, outpatients aged 18–65 yea

We study under which conditions a first-order phase transition in a composite dark sector can yield an observable stochastic gravitational-wave signal. To this end, we employ the Linear-Sigma model featuring Nf = 3, 4, 5 flavours and perform a Cornwall-Jackiw-Tomboulis computation also accounting for the effects of the Polyakov loop. The model allows us to investigate the chiral phase transition i

We report on the nuclear dependence of transverse single-spin asymmetries (TSSAs) in the production of positively charged hadrons in polarized p↑+p, p↑+Al, and p↑+Au collisions at sNN=200 GeV. The measurements have been performed at forward rapidity (1.4

Stem cell transplantation is a cornerstone in the treatment of blood malignancies. The most common method to harvest stem cells for transplantation is by leukapheresis, requiring mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow into the blood. Identifying the genetic factors that control blood CD34+ cell levels could reveal new drug targets for HSPC mobili

Context. Young open clusters (ages of less than 200 Myr) have been observed to exhibit several peculiarities in their chemical compositions. These anomalies include a slightly sub-solar iron content, super-solar abundances of some atomic species (e.g. ionised chromium), and atypical enhancements of [Ba/Fe], with values up to ~0.7 dex. Regarding the behaviour of the other s-process elements like yt

We compared the mental health of native and immigrant adolescents in Sweden from 1995 to 2011 and examined whether the municipality-level proportion of immigrant adolescents moderated the association between individual-level immigrant status and mental health. The sample (14,189 adolescents aged 15-16) was obtained from a repeated cross-sectional study conducted from 1995 to 2011. Adolescent self-

Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtai

In 1833-1874, Spain suffered 0.7 coups per year. By contrast, the Restoration (1874-1923) saw the eradication of successful coups. This can be partially attributed to the turno pacífico, which allowed the main political parties to alternate in office without dragging the military into politics. We suggest, however, that the reduction in coup risk was also associated with a conscious budget policy.

Degradation of extracellular matrix, is a prerequisite for processes like tumor invasion and angiogenesis. Numerous studies indicate that plasminogen activation, initiated by u-PA, is a key process in malignant tumor growth. The expression of u-PA as well as its receptor is increased in malignant ovarian tumors. Additionally, u-PA stimulates signal transduction leading to cell proliferation and mi