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Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), underwent [18F]flutemetamol Aβ positron emission tomography (PE
Measurements of the elliptic flow coefficient relative to the collision plane defined by the spectator neutrons v2{ΨSP} in collisions of Pb ions at center-of-mass energy per nucleon–nucleon pair sNN=2.76 TeV and Xe ions at sNN=5.44 TeV are reported. The results are presented for charged particles produced at midrapidity as a function of centrality and transverse momentum for the 5–70% and 0.2–6 Ge
BACKGROUND: Several systematic reviews (SRs), with and without meta-analyses, have investigated the use of wearable devices to improve physical activity, and there is a need for frequent and updated syntheses on the topic.OBJECTIVE: We aimed to evaluate whether using wearable devices increased physical activity and reduced sedentary behaviour in adults.METHODS: We conducted an umbrella review sear
The spatial distribution of buildings is one of the key factors influencing the local environment within a city. The quantitative measurement of building distribution can provide critical information for exploring local climate patterns in urban areas. Previous studies mainly focused on the two-dimensional spatial distribution of buildings and ignored the differences in height. In this study, a th
Human calcitonin (hCT) is a peptide hormone with therapeutic potential for bone-related disorders, yet its clinical application is hindered by a strong propensity to form amyloid fibrils. Strategies that effectively suppress hCT aggregation are therefore essential for enabling its reintroduction into pharmaceutical development. In our previous work, heme emerged as a potent inhibitor of hCT fibril
Multiple-choice tests are the gateway to important professional outcomes in the Spanish health sector. Every year, thousands of nursing, psychology, pharmacy, and biology graduates take a multiple-choice test, with wrong answers penalized, in order to access an intern position in a hospital. In such tests, willingness to guess, the decision to provide an answer instead of omitting the question can
Populärvetenskaplig sammanfattning: Under alla tider har planeten Jorden genomgått en naturlig klimat variation. Utöver denna naturliga variation i klimatet, så har människan, under det senaste århundradet, medverkat till en ökning av växthusgaser i atmosfären. Detta kan innebära att växthuseffekten intensifieras och Jorden bli utsatt för onaturliga temperaturökningar. Koldioxid (CO2), från bland In the context of climate change, it is important to understand how the terrestrial carbon cycle is interacting with the anthropogenic increase in atmospheric carbon dioxide (CO2) concentration. Boreal and subarctic regions in the northern hemisphere are great carbon pools, as well as they are subject to predicted warming. These facts place them in the absolute frontline of ecosystems that are to
The interest in Corporate Social Responsibility (CSR), which recognizes that companies have obligations that extend beyond short-run profit maximization to include notions of social and environmental concern, has increased considerably in recent decades. The globalization of the world economy and the related trade liberalization has brought forward a discussion of the importance of business as an
This essay uses the Factor Augmented Vector Autoregressive (FAVAR) approach to quantify the effects of monetary policy. Traditional methods to estimate the effects of monetary policy, such as Vector Autoregressive (VAR) models, have yielded unsatisfactory results, mainly due to sparse information sets included in the models. Augmenting the VAR model with factors summarizing the information of a va
When we introduce transaction costs the perfect Black and Scholes hedge, consisting of the underlying stock and a risk free asset, becomes infinitely expensive. By loosening the pure arbitrage argument and only considering the expected transaction costs, one can find an upper bound on the price of an option. In this essay this is done by using a framework presented by Leland (1985) and Boyle and V
This thesis examines the definition of the term 'self-contained regime', a term firstly used by the International Court of Justice in the Tehran Hostages Case and since then discussed and analyzed by international scholars of international law. The term has been used to label a treaty or set of treaties in international law that set up a system of norms that to some extent exclude the appl
This study stems from an opinion that the current approaches to the repatriation of articles of cultural heritage to their places of origin are inadequate. Attempting to find alternative ways to discuss the matter, I am using idea analysis to investigate if the museums of world culture can be problematised and criticized from a post-colonial perspective – if they can be found to be maintaining a h
Bestämmelser om tvångslikvidation vid kapitalbrist har funnits i svensk aktiebolagsrätt sedan 1895 års ABL. Idag stadgas reglerna i 25 kap. 13-20§§ ABL. Det som fastslås i ABL skiljer sig från liknande stadgor i övriga Europa, detta är något som väcker frågor. Stadgandet i 25 kap. 13-20§§ ABL ställer upp åligganden för ett bolags styrelsemedlemmar. Dessa åligganden sanktioneras med ett personligThe provisions on compulsory winding-up due to capital shortage have been found in the Swedish corporate law since 1895. Today the rules are stipulated in Chapter 25, Section 13-20 in The Swedish Corporate Act (ABL). What is set in ABL differs from similar laws in other European countries and this raises some questions. The provisions in Chapter 25, Section 13-20 ABL sets up duties for the member
This study is concerned with how the reading process reacts to detection of errors in discourse, and how this differs from cases where an error is missed or if no error is present. It sets out to investigate these questions using eye-tracking methodology. In order to determine the influence of detection of errors during the reading process, native English speakers were asked to read short news ite
A proposal of how the pre-planning process for the attack/contingency plans can be done with the purpose to achieve an effective collaboration between the fire department and the proprietor/building owner.
This study is analyzing the foreign relations of three major Iraqi communities, namely the Shia Arabs, the Kurds and Sunni Arabs. In order to properly characterize these communities’ external relations with neighboring countries, some of their foreign policy choices are examined at national and regional contexts. The issue of unresolved territorial disputes among the groups and ongoing security pr
