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Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event
Measurements of the W±→ℓ±ν and Z→ℓ+ℓ− production cross sections (where ℓ±=e±,μ±) in proton–proton collisions at s=13 TeV are presented using data recorded by the ATLAS experiment at the Large Hadron Collider, corresponding to a total integrated luminosity of 81 pb−1. The total inclusive W±-boson production cross sections times the single-lepton-flavour branching ratios are σW+ tot=11.83±0.02 (stat
The membrane-anchoring subunit of Bacillus subtilis succinate:menaquinone reductase is a protein of 202 residues containing two protoheme IX groups with bis-histidine axial ligation. Residues Kis13, His28, His70, His113, and His155 are the possible heme ligands. The transmembrane topology of this cytochrome was analyzed using fusions to alkaline phosphatase. The results support a proposed model wi
The pocket cavity is generated at the transition part between the low pressure turbine (LPT) and outlet guide vane (OGV) in a gas turbine engine. Because the important connection with OGV, the heat transfer and fluid flow need to be investigated and analyzed. In the present work, a simplified triangular pocket cavity is built and heat transfer and fluid flow are investigated experimentally and num
ATLAS has measured two-particle correlations as a function of the relative azimuthal angle, Δφ, and pseudorapidity, Δη, in s=13 and 2.76 TeV pp collisions at the LHC using charged particles measured in the pseudorapidity interval |η|
'The unbalanced hierarchy' addresses equal opportunities in academia. One of the key issues we face is that women are not being absorbed into the research community. Birgitta Odén, emeritus professor of history at the University of Lund, laid out the problems in her study 'Ju högre, desto färre' ['The higher you go, the fewer there are'] (Odén 1996). The phenomenon has also been described as 'a le
Statsmakterna kräver nu att verksamheterna vid Sveriges universitet och högskolor ska genomsyras av ett hållbarhetsperspektiv. Riksdagen har nu beslutat att dessa verksamheter ska ”främja en hållbar utveckling”. I regeringens Budgetproposition 2005/06:1 återfanns förslag till lag om ändring i högskolelagen. Där föreskrevs att 1 kap. 5 § högskolelagen (1992:1434) skall ha följande lydelse: Högskol
Thee three-dimensional structure of calcium-loaded regulatory, i.e. N- terminal, domain (1-91) of human cardiac troponin C (cNTnC) was determined by NMR in water/trifluoroethanol (91:9 v/v) solution. The single-calcium-loaded cardiac regulatory domain is in a 'closed' conformation with comparatively little exposed hydrophobic surface. Difference distance matrices computed from the families of Ca2+
L-lactate dehydrogenase (LDH) from Bacillus stearothermophilus is a redox enzyme which has a strong preference for NADH over NADPH as coenzyme. To exclude NADPH from the coenzyme-binding pocket, LDH contains a conserved aspartate residue at position 52. However, this residue is probably not solely responsible for the NADH specificity. In this report we examine the possibilities of altering the coe
Trust within teams is a central performance driver in product innovation. In this paper, we examine the antecedents to and performance implications of trust in firms engaged in radical innovation compared to those working towards incremental innovations. Our findings suggest that systematic processes and structures are significantly linked to trust in firms conducting radical innovation, but not s
With a high share of motor vehicles yielding to crossing cyclists, cyclists’ waiting time decreases and their level of service increases. The main aim of this paper is to study how this propensity to yield is connected to the traffic safety situation for cyclists at cycle crossings in a Swedish context. In a previous study, motor vehicle drivers’ yielding behaviour was studied at 65 cycle crossing
During epididymal maturation, sperm acquire the ability to swim progressively by interacting with proteins secreted by the epididymal epithelium. Beta-defensin proteins, expressed in the epididymis, continue to regulate sperm motility during capacitation and hyperactivation in the female reproductive tract. We characterized the mouse beta-defensin 41 (DEFB41), by generating a mouse model with iCre
