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The nuclear receptor peroxisome proliferator-activated receptor delta [PPARdelta/beta (NR1C2)] has been implicated in colorectal carcinogenesis by various molecular genetic observations. These observations have recently been supported by studies of activation of PPARdelta by pharmacological agents. Here we present the first report of the stimulation of breast and prostate cancer cell growth using

Objectives: To estimate intra-observer repeatability and inter-observer agreement in 1) describing adnexal masses using the International Ovarian Tumor Analysis (IOTA) terms and definitions, 2) the risk of malignancy calculated using IOTA logistic regression models LR1 and LR2, 3) the diagnosis made on the basis of subjective assessment of ultrasound images. Methods: One hundred and three adne

The mixed-valence triiron complexes [Fe3(CO)7-x (PPh3) x (μ-edt)2] (x = 0-2; edt = SCH2CH2S) and [Fe3(CO)5(κ(2)-diphosphine)(μ-edt)2] (diphosphine = dppv, dppe, dppb, dppn) have been prepared and structurally characterized. All adopt an anti arrangement of the dithiolate bridges, and PPh3 substitution occurs at the apical positions of the outer iron atoms, while the diphosphine complexes exist onl

Aims To investigate efficacy and safety of dual therapy with liraglutide and metformin in comparison to glimepiride and metformin, and metformin monotherapy over 2?years in patients with type 2 diabetes. Methods In the 26-week the Liraglutide Effect and Action in Diabetes (LEAD)-2 core trial, patients (n?=?1091) were randomized (2?:?2?:?2?:?1:?2) to liraglutide (0.6, 1.2 or 1.8?mg once-daily), pla

Purpose: To evaluate how children with spina bifida (SB) participate in school-related activities and to explore if their motor and process skills in task performance were related to their level of active participation in school. Method: Fifty children from a geographical cohort of children with SB (aged 6-14 years) and their teachers rated the children's frequency of participation in school-relat

One feature of climate change is the increasing heat exposure in many workplaces where efficient cooling systems cannot be applied. Excessive heat exposure is a particular problem for working people because of the internal heat production when muscle work is carried out. The physiological basis for severe heat stroke, other clinical effects, and heat exhaustion is well known. One feature of this h

Vacuum-assisted wound closure (VAC®) therapy is considered to be superior to conventional dressings in the treatment of peri-vascular groin infections after vascular surgery at our department. Therefore, we wanted to perform an early interim analysis of clinical outcome in these seriously ill patients at risk for amputation and death. Patients were randomised to either VAC® (n = 5) or Sorbalgon® (

Purpose — We wanted to examine the potential of the Scandinavian Sarcoma Group (SSG) Central Register, and evaluate referral and treatment practice for soft-tissue sarcomas in the extremities and trunk wall (STS) in the Nordic countries. Background — Based on incidence rates from the literature, 8,150 (7,000–9,300) cases of STS of the extremity and trunk wall should have been diagnosed in Norway,

The popular uprising that began in Syria in 2011 generated an unprecedented number of YouTube videos recording events in Syria; this emphasized how the social media platform had become an important alternative space for news and information, a space beyond the control of the government. In this article, I address the role of Syrian video activism in the Syrian revolution, and pay particular attent

A total of 1280 80-year-old men in the community of Malmö were questioned about smoking habits and the occurrence of cardiovascular disease (CVD). After a careful medical and duplex ultrasound examination, four groups were selected for further studies: (1) no CVD, non-smokers: (2) no CVD, smokers: (3) CVD, smokers: (4) CVD, non-smokers. In total 122 individuals participated. The average tobacco co

BACKGROUND: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterpart

In this pilot study (RibaC), 58 hepatitis C virus (HCV) genotype 1 infected treatment-naïve patients were randomized to (i) 2 weeks ribavirin double dosing concomitant with pegylated interferon-α (pegIFN-α), (ii) 4 weeks ribavirin mono-therapy prior to adding pegIFN-α, or (iii) standard-of-care (SOC) ribavirin dosing concurrent with pegIFN-α. Four weeks of ribavirin mono-therapy resulted in a mean

Genome-wide association studies (GWAS) have generated considerable interest in glucokinase regulatory protein (GKRP; gene name GCKR) which is an inhibitor of hepatic glucokinase (GCK), an enzyme that plays a critical role in glucose update and disposal in liver. From the initial discovery of GCKR variants associated with triglyceride and glucose levels through the identification of pleiotropic ass

Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare report

Likt RB präglas LSF av normer som fördelar ansvaret mellan skiljenämnden och parterna. En fundamental princip inom civilprocessrätten är dispositionsprincipen, vilken främst kommer till uttryck genom 17 kap. 3 § RB. Av paragrafens andra mening framgår att domstolen i dispositiva tvistemål inte får grunda sitt avgörande på en omständighet som inte åberopats av rätt part. Regeln har preciserats i räAs with the SCJP, the SAA is characterized by norms that allocate responsibility between the arbitral tribunal and the parties. A fundamental principle of civil procedure law is the principle of party disposition, primarily expressed in Chapter 17, Section 3 of the SCJP. The second sentence of this section provides that a court may not, in disputes amenable to settlement, base its judgment on a ci

This thesis aims to discover how Baltic and Nordic regional identities are discussed in 448 speeches by the presidents of Estonia, Latvia and Lithuania during 1991 – 2021, and how regional identities in these countries may have changed over time. The research is conducted as a critical discourse analysis, with an addition of elements of comparative analysis. The theoretical framework consists of A

Delivering essential services to burgeoning peri-urban cities in the Sub-Sahara will only become an increasing challenge, as the population in this region is expected to double by 2050. Finding effective governance arrangements, institutional settings and building participatory arenas that give a greater voice to citizens and foster greater responsiveness from democratic authorities is a delicate

In the past decade, micro-enterprise development has gained popularity as an intervention in the Global South, including Colombia, a country where more than 90% of businesses are micro. For decades, this country has endured an internal conflict that has left millions of victims of forced displacement, who live in vulnerable situations and, in many cases, resort to creating micro-enterprises to mak