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BACKGROUND: Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterised by progressive neurological degeneration, where the rate of neurological disease progression varies depending on age at neurological onset. We report longitudinal data on functional disease progression and safety observations in patients in the international NPC Registry who received continuous treatment w
This report explores what the Nordic countries can do to promote the use of recyclable plastic components in electrical and electronic products, with particular focus on minimising their hazardous chemical component. The report provides an overview of the hazardous additives currently used in the plastic components of EEE, drawing on information available from legislation and supporting studies, r
The European Spallation Source (ESS) is a neutron-based research facility under construction in Lund in southern Sweden. The spallation reactions will generate not only the desired neutrons, but also many radioactive byproducts, including 14C. As part of the licensing process, and as recommended by the IAEA, various preoperational studies are being carried out, including mapping the “zero-point” r
A search for supersymmetry in events with four or more charged leptons (electrons, muons and τ-leptons) is presented. The analysis uses a data sample corresponding to 139 fb−1 of proton-proton collisions delivered by the Large Hadron Collider at s = 13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying τ-leptons are designed to target several su
Results from the radiological environmental monitoring of the European Spallation Source (ESS) are presented for year 2020.Among the 63 environmental samples analysed for gamma emitting radionuclides, no elevated levels of anthropogenic radioactivity were observed. All samples (except two samples of lichen) had activity concentrations below the MDA for the natural radionuclides as well as 137Cs, a
Extending the lifetime of products is seen as a key objective for realising the vision of a Circular Economy. One way to increase the lifespan of products is to enable more repair activities. However, consumers encounter a variety of barriers for repairs, prompting public authorities in Europe and the US to adopt or propose policies in support of consumer repairs. Sweden has recently adopted a cir
BackgroundGraft-contaminating tumor cells correlate with inferior outcome in high-risk neuroblastoma patients undergoing hematopoietic stem cell transplantation and can contribute to relapse. Motivated by the potential therapeutic benefit of tumor cell removal as well as the high prognostic and diagnostic value of isolated circulating tumor cells from stem cell grafts, we established a label-free
Introduction: Fast-track referral pathways for patients with nonspecific, serious symptoms have been implemented in several countries. Our objective was to analyze time intervals in the diagnostic routes of patients diagnosed with cancer at Sweden’s first Diagnostic Center (DC) for nonspecific symptoms and compare with time intervals of matched control patients. Methods: Adult patients with nonspe
Decreasing floral resources as a result of habitat loss is one of the key factors in the decline of pollinating insects worldwide. Understanding which plants pollinators use is vital to inform the provision of appropriate floral resources to help prevent pollinator loss. Using a globally important pollinator, the honeybee, we show how changes in agricultural intensification, crop use and the sprea
Grass (Poaceae) pollen is the most important outdoor aeroallergen,1 exacerbating a range of respiratory conditions, including allergic asthma and rhinitis ("hay fever").2-5 Understanding the relationships between respiratory diseases and airborne grass pollen with a view to improving forecasting has broad public health and socioeconomic relevance. It is estimated that there are over 400 million pe
Popular Abstract in Swedish För att vi ska kunna lösa globala problem som miljöförstöring och fattigdom är det många som menar att den privata sektorn måste involveras på ett aktivt sätt. I den här avhandlingen, som består av en introduktion och fem vetenskapliga artiklar som tidigare publicerats i internationella tidskrifter, studeras ett exempel på hur privata aktörer faktiskt redan involverats It is commonly argued that the private sector needs to become actively involved for society to stand a chance of solving the most pressing global problems. This thesis, consisting of five articles previously published in refereed journals and an introductory essay, studies one case of private actor participation in global environmental governance: the Kyoto Protocol’s Clean Development Mechanism (
The upcycling trend has received renewed attention in the past few years due to growing concerns for the environment related to increased resource consumption and waste volumes. Indeed, cities across the world are supporting resource upcycling initiatives by establishing do-it-yourself (DIY) repair cafes and makerspaces as a means to transform societies towards sustainable develop-ment. However, t
A search for invisible decays of the Higgs boson as well as searches for dark matter candidates, produced together with a leptonically decaying Z boson, are presented. The analysis is performed using proton−proton collisions at a centre-of-mass energy of 13 TeV, delivered by the LHC, corresponding to an integrated luminosity of 139 fb−1 and recorded by the ATLAS experiment. Assuming Standard Model
This article focuses on the role of lay health promoters in the Lindängen initiative, a community-based participatory research (CBPR) programme for health promotion that started 2016 in a low-income neighbourhood in the outskirts of Malmö, southern Sweden. The programme aimed to support equitable health and develop an innovative model for community health promotion. The purpose of this article is
